Transcription of mtDNA and dyslipidemia are ameliorated by aerobic exercise in type 2 diabetes

Benite-Ribeiro, Sandra Aparecida; Lucas-Lima, Kamila Lauany; Jones, Jessica; Santos, Júlia Matzenbacher dos

doi:10.1007/s11033-020-05725-8

Cited by 7 publications

(1 citation statement)

References 24 publications

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“…As obesity and diabetes reduce mitochondrial biogenesis in skeletal muscle and increase the accumulation of dysfunctional cellular organelles, exercise training can attenuate mitochondrial dysfunction, allowing the mitochondria to maintain the balance between mitochondrial dynamics and mitophagy [57][58][59][60]. These chronic training adaptations increase the ability for oxidative metabolism (providing energy for a longer exercise time) and result in less accumulation of fatty acids and lipid byproducts in blood caused by the diabetic phenotype [61,62].…”

Section: The Long-term Effects Of Regular Exercise On Glycemic Control and Overall Health In Insulin Resistance Statesmentioning

confidence: 99%

Exercise as a Therapeutic Intervention in Gestational Diabetes Mellitus

et al. 2021

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Gestational Diabetes Mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Regular exercise is important for a healthy pregnancy and can lower the risk of developing GDM. For women with GDM, exercise is safe and can affect the pregnancy outcomes beneficially. A single exercise bout increases skeletal muscle glucose uptake, minimizing hyperglycemia. Regular exercise training promotes mitochondrial biogenesis, improves oxidative capacity, enhances insulin sensitivity and vascular function, and reduces systemic inflammation. Exercise may also aid in lowering the insulin dose in insulin-treated pregnant women. Despite these benefits, women with GDM are usually inactive or have poor participation in exercise training. Attractive individualized exercise programs that will increase adherence and result in optimal maternal and offspring benefits are needed. However, as women with GDM have a unique physiology, more attention is required during exercise prescription. This review (i) summarizes the cardiovascular and metabolic adaptations due to pregnancy and outlines the mechanisms through which exercise can improve glycemic control and overall health in insulin resistance states, (ii) presents the pathophysiological alterations induced by GDM that affect exercise responses, and (iii) highlights cardinal points of an exercise program for women with GDM.

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