Transcription profile of human endogenous retroviruses in response to dengue virus serotype 2 infection

Wang, Miao; Qiu, Yang; Liu, Haizhou; Liang, Bing; Fan, Baofeng; Zhou, Xi; Liu, Di

doi:10.1016/j.virol.2020.01.014

Cited by 27 publications

(28 citation statements)

References 41 publications

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“…In our previous study, we found a correlation between viral infection-induced DEHERVs and DEGs and proposed the concept of DEHERV-G pair to reveal their potential interactions (Wang et al 2020 ). In this study, we detected DEHERV-G pairs in each dataset.…”

Section: Resultsmentioning

confidence: 98%

“…In a previous study, we reported the transcription profile of HERVs in DENV-2 infected A549 cells using high-throughput sequencing for the first time and found the correlation between activated HERV sites and human genes (Wang et al 2020 ). In this study, using the same pipeline, we reanalyzed the RNA-sequencing data associated with 11 viral infections, including those of Flu-A, Flu-B, ZIKV, HCV, CCHFV, RSV, SARS-CoV-2, WNV, RHV, MV, and EBV.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we previously reported the transcriptional profile of HERV loci in human A549 cells infected with dengue virus serotype 2 (DENV-2) (Wang et al 2020); we found that a large number of HERV loci were up-regulated in DENV-2 infected cells. Interestingly, the reactivated loci tended to be distributed near immune-related genes and were expressed in a pattern consistent with that of the genes.…”

Section: Introductionmentioning

confidence: 87%

“…Data analyses were performed as described previously (Wang et al 2020 ). Briefly, the quality of raw reads were assessed with FastQC (v 0.11.5) (Andrews 2010 ), and the low-quality reads were filtered out with Trimmomatic (v 0.38) (Bolger et al 2014 ).…”

Section: Methodsmentioning

confidence: 99%

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Transcriptome Analyses Implicate Endogenous Retroviruses Involved in the Host Antiviral Immune System through the Interferon Pathway

Wang

Liu

et al. 2021

Virol. Sin.

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Human endogenous retroviruses (HERVs) are the remains of ancient retroviruses that invaded our ancestors’ germline cell and were integrated into the genome. The expression of HERVs has always been a cause for concern because of its association with various cancers and diseases. However, few previous studies have focused on specific activation of HERVs by viral infections. Our previous study has shown that dengue virus type 2 (DENV-2) infection induces the transcription of a large number of abnormal HERVs loci; therefore, the purpose of this study was to explore the relationship between exogenous viral infection and HERV activation further. In this study, we retrieved and reanalyzed published data on 21 transcriptomes of human cells infected with various viruses. We found that infection with different viruses could induce transcriptional activation of HERV loci. Through the comparative analysis of all viral datasets, we identified 43 key HERV loci that were up-regulated by DENV-2, influenza A virus, influenza B virus, Zika virus, measles virus, and West Nile virus infections. Furthermore, the neighboring genes of these HERVs were simultaneously up-regulated, and almost all such neighboring genes were interferon-stimulated genes (ISGs), which are enriched in the host’s antiviral immune response pathways. Our data supported the hypothesis that activation of HERVs, probably via an interferon-mediated mechanism, plays an important role in innate immunity against viral infections.

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Transcriptome Analyses Implicate Endogenous Retroviruses Involved in the Host Antiviral Immune System through the Interferon Pathway

Wang

Liu

et al. 2021

Virol. Sin.

Self Cite

View full text Add to dashboard Cite

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“…While many of them are usually dormant, they can be reactivated by several stimuli, including viral infections. For example, Dengue, Herpes simplex, Influenza and Human Immunodeficiency viruses have all been shown to induce the transcription and translation of endogenous retroviral elements (1)(2)(3)(4)(5). Although human ERVs (HERVs) are not known to produce infectious viral particles in vivo, this resurgence of virus-derived RNAs and proteins in our cells may seem alarming.…”

Section: Introductionmentioning

confidence: 99%

Switching Sides: How Endogenous Retroviruses Protect Us from Viral Infections

Badarinarayan

Sauter

2021

J Virol

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Long disregarded as junk DNA or genomic dark matter, endogenous retroviruses (ERVs) turned out to represent important components of the antiviral immune response. These remnants of once-infectious retroviruses not only regulate cellular immune activation, but may even directly target invading viral pathogens. In this review, we summarize mechanisms, by which retroviral fossils protect us from viral infections. One focus will be on recent advances in the role of ERVs as regulators of antiviral gene expression.

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Human endogenous retroviruses in viral disease and therapy

Fan

Cui

2022

Clinical and Translational Dis

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As retained sequences of ancient retroviruses, human endogenous retroviruses (HERVs) are widespread in the human genome. Although most HERVs have been inert throughout evolution, several HERVs are still functional and involved in various diseases, such as autoimmune diseases, cancer, neurological diseases and viral infection. Hence, certain types of therapies targeting HERVs or utilizing HERV tools have been developed. Here, we summarize recent findings on the role of HERVs in viral infection, including HERV dysregulation in different kinds of viral infections and the potential mechanisms of HERV‐mediated antiviral immunity. In addition, we provide an overview of HERV‐related therapies that directly target HERVs or are indirectly based on HERVs to improve the efficacy of vaccines and drugs.

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Transcription profile of human endogenous retroviruses in response to dengue virus serotype 2 infection

Cited by 27 publications

References 41 publications

Transcriptome Analyses Implicate Endogenous Retroviruses Involved in the Host Antiviral Immune System through the Interferon Pathway

Transcriptome Analyses Implicate Endogenous Retroviruses Involved in the Host Antiviral Immune System through the Interferon Pathway

Switching Sides: How Endogenous Retroviruses Protect Us from Viral Infections

Human endogenous retroviruses in viral disease and therapy

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