2015
DOI: 10.1371/journal.pntd.0003978
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Transcription Profiling of Malaria-Naïve and Semi-immune Colombian Volunteers in a Plasmodium vivax Sporozoite Challenge

Abstract: BackgroundContinued exposure to malaria-causing parasites in endemic regions of malaria induces significant levels of acquired immunity in adult individuals. A better understanding of the transcriptional basis for this acquired immunological response may provide insight into how the immune system can be boosted during vaccination, and into why infected individuals differ in symptomology.Methodology/Principal FindingsPeripheral blood gene expression profiles of 9 semi-immune volunteers from a Plasmodium vivax m… Show more

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Cited by 33 publications
(48 citation statements)
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“…Volunteer 026, who displayed parasitemia but was asymptomatic, had a hybrid profile 236 consisting of a strong interferon response and inflammatory activation, also with differences 237 in modules related to the cell cycle as observed previously in semi-immune individuals in 238 response to a P. vivax CHMI [16]. She also had a signature of platelet activation which was 239 recently proposed to have protective properties against malaria infection by binding 240 infected erythrocytes and killing the parasite specifically by factor 4 activity [40,41].…”
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confidence: 70%
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“…Volunteer 026, who displayed parasitemia but was asymptomatic, had a hybrid profile 236 consisting of a strong interferon response and inflammatory activation, also with differences 237 in modules related to the cell cycle as observed previously in semi-immune individuals in 238 response to a P. vivax CHMI [16]. She also had a signature of platelet activation which was 239 recently proposed to have protective properties against malaria infection by binding 240 infected erythrocytes and killing the parasite specifically by factor 4 activity [40,41].…”
mentioning
confidence: 70%
“…For example, lack of expression of the Duffy (Fy) blood group in African 12 populations associates with protection from P. vivax blood infection [8,9] and consequently from 13 the clinical manifestations associated with this parasite stage, despite its full development in the 14 liver. This species also has the capacity to remain dormant as hypnozoites in the liver and 15 periodically reactivate, inducing clinical relapses which represent an enormous challenge for P. 16 vivax control and elimination and highlights the importance of developing vaccines targeting the 17 parasite liver forms. Rational design of malaria vaccines is likely to be accelerated by enhanced 18 understanding of the molecular mechanisms involved in the clinical immunity developed in 19 individuals permanently exposed to infection in endemic areas [10,11], or by sterile immunity 20 experimentally induced by vaccination with attenuated parasites [12].…”
Section: Author Summarymentioning
confidence: 99%
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“…To assess the applicability of MORNs (and insights derived from them) from the NHP model of P. cynomolgi infection to human vivax malaria, we tested whether changes in host transcriptional pathways associated with the MORNs identified here could be recapitulated using a recently published human PB transcriptomics dataset from P. vivax patients (GSE67184) (Rojas-Pena et al, 2015). 735 of 6,154 genes were differentially expressed at the time of diagnosis, yielding 262 significantly enriched curated pathways (FDR < 0.05).…”
Section: Resultsmentioning
confidence: 99%
“…We used the blood transcriptome data sets deposited in Gene Expression Omnibus (GEO) under accession numbers GSE67184, GSE61252 associated with the in vivo P. vivax sporozoite challenge [11] and ex vivo P. vivax asexual stage culture [12] respectively. We also use the in vivo P. falciparum infection genomic reads [13] deposited in DNA Data Bank of Japan (DDBJ) under accession number DRA000949 to compare the transcript abundances with the above datasets.…”
Section: Methodsmentioning
confidence: 99%