Transcriptional activation of a chimeric retrogene PIPSL in a hominoid ancestor

Matsumura, Kenya; Imai, Hiroo; Go, Yasuhiro; Kusuhara, Masatoshi; Yamaguchi, Ken; Shirai, Tomoyuki; Ohshima, Kousei

doi:10.1016/j.gene.2018.08.033

Cited by 2 publications

(1 citation statement)

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“…This gene was created via a unique mechanism, whereby two tandemly arranged genes (a lipid kinase and a proteasome subunit) were assembled at the RNA level, and the resulting chimera was subsequently reverse transcribed and integrated into the genome of the common ancestor of extant hominid species using LINE-1 [4]. He showed that PIPSL is expressed in the testis of the white-handed gibbon and that the cluster of its transcription start sites in testes is conserved in gibbons, orangutans, and humans [5]. Although its precise function remains unelucidated, this unique gene has been conserved in structure and transcriptional regulation for approximately 20 million years.…”

Section: Highlights Of the Talksmentioning

confidence: 99%

TE studies in Japan: the fourth Japanese meeting on host–transposon interactions

Ichiyanagi

2019

Mobile DNA

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The fourth Japanese meeting entitled “Biological Function and Evolution through Interactions between Hosts and Transposable Elements (TEs)” was held on August 20–21, 2018 at the National Institute of Genetics (NIG), Mishima, Japan. The meeting was supported by NIG, and its objective was to bring together researchers who study the diverse roles of TEs in genome evolution, as well as host defense systems against TE mobility, such as chromatin modifications, small RNAs, and others. Here, we present the highlights of the talks given by 14 invited speakers.Organizers: Kenji Ichiyanagi (chief), Kuniaki Saito, and Tetsuji Kakutani.

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Section: Highlights Of the Talksmentioning

confidence: 99%