Transcriptional activities of histone H3, cyclin D1 and claudin 7 encoding genes in laryngeal cancer

Kapral, Małgorzata; Strzałka‐Mrozik, Barbara; Kowalczyk, Małgorzata; Paluch, Jarosław; Gola, Joanna; Gierek, T; Węglarz, Ludmiła

doi:10.1007/s00405-010-1471-0

Cited by 10 publications

(10 citation statements)

References 23 publications

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“…Cyclin D1 intense expression is seen in 40-70 % of LSCC. 10,11,20 In present study, cyclin D1 showed intense/significant expression in 31/72 (43%) patients.…”

Section: Cyclin D1supporting

confidence: 50%

“…Numerous studies in the literature have stated the role of all these markers in tumorigenesis, diagnosis, prognosis as well as therapeutic management of the LSCC and other types of cancer. [8][9][10][11][12][13] The present study was postulated to study the expression of three proliferation markers in LSCC. The study also aimed to establish the correlation of all three proliferation markers with various clinical and histo-pathological parameters, treatment outcomes as well as survival in patients with LSCC.…”

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confidence: 99%

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Expression of proliferation markers in laryngeal squamous cell carcinoma: an association with clinico-pathological factors and treatment outcomes

Iype

Balakrishna

Subhadradevi

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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Background: The study was done with the objective to study the expression of epidermal growth factor receptor (EGFR), cyclin D1 and Ki-67 in laryngeal squamous cell carcinoma and to assess the correlation of all three proliferation markers with various clinic-pathological parameters, the treatment outcomes as well as survival.Methods: We prospectively evaluated the surgical specimens of 72 laryngeal squamous cell carcinoma (LSCC) patients, treated with primary surgery and post-operative adjuvant therapy. Tumor tissue samples were analysed for the expression of EGFR, cyclin D1 and Ki-67 markers and analysis were done by immune-histochemistry and western blot test. Results: EGFR showed significant expression in 67.6% and was insignificant in 31.9% patients in our analysis of 72 tumor samples. Cyclin D1 showed intense expression in 43%, and was insignificant in 57% patients. Ki-67 was intensely expressed in 43% patients. There was no correlation between expression of these markers with age, T-stage and N-stage. However, all the three markers showed significantly intense expression in tumours with extra capsular disease as well as perineural invasion (PNI) both of which are features of invasiveness of the tumor.Conclusions: Estimation of biomarkers such as EGFR, cyclin Dl, and Ki-67 could be beneficial in predicting tumor aggressiveness, prognosis and survival in LSCC patients. Thus, all the three proliferation markers can be categorized as markers of invasiveness. Combination of proliferation markers-EGFR, cyclin D1 and Ki-67 is useful pre-operatively in planning surgical strategies so as to decide a more radical approach for the resection of the primary as well as neck dissection.

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“…Cyclin D1 intense expression is seen in 40-70 % of LSCC. 10,11,20 In present study, cyclin D1 showed intense/significant expression in 31/72 (43%) patients.…”

Section: Cyclin D1supporting

confidence: 50%

mentioning

confidence: 99%

Expression of proliferation markers in laryngeal squamous cell carcinoma: an association with clinico-pathological factors and treatment outcomes

Iype

Balakrishna

Subhadradevi

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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“…Modification on histone protein could affect the protein stability, protein-protein interaction, protein localization, and DNA binding [83]. Laryngeal carcinoma has a higher expression level of H3, however, the modification status of the overexpressed histone is not yet evaluated [84]. Takahashi et al reported that histone H3; was overexpressed in gastric adenocarcinoma and it was subjected to phosphorylation [85].…”

Section: Epigenetic Alterations In Human Malignanciesmentioning

confidence: 99%

Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma

Wong

Gao

et al. 2012

Journal of Oncology

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Laryngeal carcinoma is a common head and neck cancer with poor prognosis. Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important field in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence. Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies. Global epigenetic change is now regarded as a molecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use.

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“…A recent study showed that the inhibition of CCND1 suppresses cell proliferation in NSCLC cell lines ( Li et al, 2016 ). Several studies have reported the inhibition of cell proliferation, ( Chen et al, 2013 ; Zhu et al, 2010 ) suppression of cell cycle progression ( Chen et al, 2016 ; Kapral et al, 2011 ) and increased apoptosis ( Dai et al, 2016 ; Lai et al, 2010 ; Wang et al, 2014 ). In the present study, we also observed that GSK-J4 induced the suppression of CCND1 gene expression and might be responsible for the suppression of cell cycle progression, followed by the inhibition of cell proliferation and increased cell death.…”

Section: Discussionmentioning

confidence: 99%

GSK-J4-Mediated Transcriptomic Alterations in Differentiating Embryoid Bodies

Mandal

Kim

Kang

et al. 2017

Molecules and Cells

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Histone-modifying enzymes are key players in the field of cellular differentiation. Here, we used GSK-J4 to profile important target genes that are responsible for neural differentiation. Embryoid bodies were treated with retinoic acid (10 μM) to induce neural differentiation in the presence or absence of GSK-J4. To profile GSKJ4-target genes, we performed RNA sequencing for both normal and demethylase-inhibited cells. A total of 47 and 58 genes were up- and down-regulated, respectively, after GSK-J4 exposure at a log2-fold-change cut-off value of 1.2 (p-value < 0.05). Functional annotations of all of the differentially expressed genes revealed that a significant number of genes were associated with the suppression of cellular proliferation, cell cycle progression and induction of cell death. We also identified an enrichment of potent motifs in selected genes that were differentially expressed. Additionally, we listed upstream transcriptional regulators of all of the differentially expressed genes. Our data indicate that GSK-J4 affects cellular biology by inhibiting cellular proliferation through cell cycle suppression and induction of cell death. These findings will expand the current understanding of the biology of histone-modifying enzymes, thereby promoting further investigations to elucidate the underlying mechanisms.

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Transcriptional activities of histone H3, cyclin D1 and claudin 7 encoding genes in laryngeal cancer

Cited by 10 publications

References 23 publications

Expression of proliferation markers in laryngeal squamous cell carcinoma: an association with clinico-pathological factors and treatment outcomes

Expression of proliferation markers in laryngeal squamous cell carcinoma: an association with clinico-pathological factors and treatment outcomes

Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma

GSK-J4-Mediated Transcriptomic Alterations in Differentiating Embryoid Bodies

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