Transcriptional Control of Brown Fat Determination by PRDM16

Seale, Patrick; Kajimura, Shingo; Yang, Wenli; Chin, Stephanie; Rohas, Lindsay M.; Uldry, Marc; Tavernier, Geneviève; Langin, Dominique; Spiegelman, Bruce M.

doi:10.1016/j.cmet.2007.06.001

Cited by 1,042 publications

(1,107 citation statements)

References 81 publications

Supporting

Mentioning

1,050

Contrasting

Unclassified

Order By: Relevance

“…In vitro, PPAR expression is high in proliferating brown pre-adipocytes and increases further following induction of differentiation [50]. [53,54]. Surprisingly, PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis.…”

Section: Page 7 Of 25mentioning

confidence: 97%

“…PRDM16 functions to stimulate adipogenesis in these mesenchymal precursors by interacting with, and co-regulating the activity of other transcription factors and co-activators, including PPAR coactivator-1 (PGC1 ) (see below). Crucially, (ligand-independent) binding to and co-activation of PPAR is essential for the adipogenic function of PRDM16 [53,54].…”

Section: Page 7 Of 25mentioning

confidence: 99%

See 1 more Smart Citation

PPARs and adipocyte function

Christodoulides

Vidal-Puig

2010

Molecular and Cellular Endocrinology

115

View full text Add to dashboard Cite

Abstract:For long viewed as passive lipid storage depots, adipocytes are now recognised as key players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last two decades of research have seen the emergence of transcription factors of the peroxisome proliferator-activated receptor (PPAR) family as central regulators of lipid and glucose homeostasis and molecular targets for drugs to treat hyper-lipidaemia and type 2 diabetes mellitus. In this review we discuss the characteristics of PPARs and the role of the different isotypes in adipocyte biology.

show abstract

Section: Page 7 Of 25mentioning

confidence: 97%

Section: Page 7 Of 25mentioning

confidence: 99%

PPARs and adipocyte function

Christodoulides

Vidal-Puig

2010

Molecular and Cellular Endocrinology

115

View full text Add to dashboard Cite

show abstract

“…In particular, BMP2 and BMP4 have been shown to promote the commitment Interaction between adipose tissue and muscle of precursors in the white adipogenic pathway, whereas BMP7 selectively stimulates the commitment of brown precursors. BMP7 then induces the expression of transcriptional regulator PRDM16 (PR domain zinc finger protein 16) required for brown fat determination (Seale et al, 2007;Tseng et al, 2008), while suppressing the expression of genes specific for white fat cells . However, the possibility that WAT and BAT may originate from different cell progenitors remains open.…”

Section: Dynamics Of At Growthmentioning

confidence: 99%

Ontogenesis of muscle and adipose tissues and their interactions in ruminants and other species

Bonnet

Cassar-Malek

Chilliard

et al. 2010

Animal

113

View full text Add to dashboard Cite

The lean-to-fat ratio, that is, the relative masses of muscle and adipose tissue, is a criterion for the yield and quality of bovine carcasses and meat. This review describes the interactions between muscle and adipose tissue (AT) that may regulate the dynamic balance between the number and size of muscle v. adipose cells. Muscle and adipose tissue in cattle grow by an increase in the number of cells (hyperplasia), mainly during foetal life. The total number of muscle fibres is set by the end of the second trimester of gestation. By contrast, the number of adipocytes is never set. Number of adipocytes increases mainly before birth until 1 year of age, depending on the anatomical location of the adipose tissue. Hyperplasia concerns brown pre-adipocytes during foetal life and white pre-adipocytes from a few weeks after birth. A decrease in the number of secondary myofibres and an increase in adiposity in lambs born from mothers severely underfed during early pregnancy suggest a balance in the commitment of a common progenitor into the myogenic or adipogenic lineages, or a reciprocal regulation of the commitment of two distinct progenitors. The developmental origin of white adipocytes is a subject of debate. Molecular and histological data suggested a possible transdifferentiation of brown into white adipocytes, but this hypothesis has now been challenged by the characterization of distinct precursor cells for brown and white adipocytes in mice. Increased nutrient storage in fully differentiated muscle fibres and adipocytes, resulting in cell enlargement (hypertrophy), is thought to be the main mechanism, whereby muscle and fat masses increase in growing cattle. Competition or prioritization between adipose and muscle cells for the uptake and metabolism of nutrients is suggested, besides the successive waves of growth of muscle v. adipose tissue, by the inhibited or delayed adipose tissue growth in bovine genotypes exhibiting strong muscular development. This competition or prioritization occurs through cellular signalling pathways and the secretion of proteins by adipose tissue (adipokines) and muscle (myokines), putatively regulating their hypertrophy in a reciprocal manner. Further work on the mechanisms underlying cross-talk between brown or white adipocytes and muscle fibres will help to achieve better understanding as a prerequisite to improving the control of body growth and composition in cattle.

show abstract

“…Several key transcriptional regulators, such as PRDM16 (PR domain containing 16) and its co-factors, have been identified, allowing researchers to generate functional BAT depots in vivo by genetic approaches. [6][7][8][9][10] As a next step toward novel anti-obesity strategies to pharmacologically promote BAT thermogenesis, we need to gain a better understanding of the enzymatic components and signaling pathways that control brown adipocyte development and thermogenesis. Here, I will overview recent advances in this topic with a special emphasis on the PRDM16 pathway.…”

Section: Introductionmentioning

confidence: 99%

Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway

Kajimura

2015

Int J Obes Supp

View full text Add to dashboard Cite

Obesity develops from a chronic energy imbalance in which energy intake exceeds energy expenditure. As brown adipose tissue (BAT) dissipates energy and produces heat, increasing energy expenditure via BAT thermogenesis may constitute a novel therapeutic intervention for the treatment of obesity and obesity-related diseases. Studies over the past few years have identified key regulatory molecules of brown and beige adipocyte biogenesis, including a dominant transcriptional co-regulator PRDM16 (PR domain containing 16) and its co-factors, which allows for engineering functional BAT by genetic approaches. A next step toward the goal of promoting BAT thermogenesis by pharmacological approaches necessitates a better understanding of the enzymatic components and signaling pathways for brown and beige adipocyte development. This review covers recent advances regarding this topic, with a special emphasis on the PRDM16 transcriptional pathway.

show abstract

Transcriptional Control of Brown Fat Determination by PRDM16

Cited by 1,042 publications

References 81 publications

PPARs and adipocyte function

PPARs and adipocyte function

Ontogenesis of muscle and adipose tissues and their interactions in ruminants and other species

Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway

Contact Info

Product

Resources

About