Transcriptional control of metabolism by interferon regulatory factors

Ahmad, Zunair; Kahloan, Wahab; Rosen, Evan D.

doi:10.1038/s41574-024-00990-0

Nat Rev Endocrinol

2024

DOI: 10.1038/s41574-024-00990-0

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Transcriptional control of metabolism by interferon regulatory factors

Zunair Ahmad,

Wahab Kahloan,

Evan D. Rosen

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2024

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Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications

Fan,

Tian,

Chen

et al. 2024

World J Diabetes

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Diabetes mellitus (DM) is one of the major causes of mortality worldwide, with inflammation being an important factor in its onset and development. This review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway in mediating inflammatory responses. Furthermore, it comprehensively presents related research progress and the subsequent involvement of this pathway in the pathogenesis of early-stage DM, diabetic gastroenteropathy, diabetic cardiomyopathy, non-alcoholic fatty liver disease, and other complications. Additionally, the role of cGAS-STING in autonomic dysfunction and intestinal dysregulation, which can lead to digestive complications, has been discussed. Altogether, this study provides a comprehensive analysis of the research advances regarding the cGAS-STING pathway-targeted therapeutic agents and the prospects for their application in the precision treatment of DM.

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Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications

Fan,

Tian,

Chen

et al. 2024

World J Diabetes

View full text Add to dashboard Cite

show abstract

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Transcriptional control of metabolism by interferon regulatory factors

Cited by 1 publication

References 181 publications

Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications

Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications

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