2022
DOI: 10.1007/s12035-022-03090-0
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Transcriptional Control of Peripheral Nerve Regeneration

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Cited by 27 publications
(18 citation statements)
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“…46,69,84 Activating transcription factor 3 is a transcriptional factor de novo upregulated after neuronal injury and associated with transcriptional reprogramming, regeneration, and TRPV1 activation. 9,68,101 This observation is in line with the ability for HNSCC-derived sEVs to induce neurite outgrowths 2,50,52 and suggests that cancer pain has a neuropathic component. 96 The upregulation of ATF3 in response to sEVs supports the idea that sEVs drastically impact neuronal gene expression to switch to a transcriptome facilitating axon elongation and neuronal sensitization.…”
Section: Discussionsupporting
confidence: 67%
“…46,69,84 Activating transcription factor 3 is a transcriptional factor de novo upregulated after neuronal injury and associated with transcriptional reprogramming, regeneration, and TRPV1 activation. 9,68,101 This observation is in line with the ability for HNSCC-derived sEVs to induce neurite outgrowths 2,50,52 and suggests that cancer pain has a neuropathic component. 96 The upregulation of ATF3 in response to sEVs supports the idea that sEVs drastically impact neuronal gene expression to switch to a transcriptome facilitating axon elongation and neuronal sensitization.…”
Section: Discussionsupporting
confidence: 67%
“…In addition, sox10, a key factor for peripheral nerve myelination, regulates pmp22 and MBP, which are markers of Schwann cell maturation. 33,34 It has been shown that demyelination can be improved by increasing the expression of sox10, krox20, MBP and pmp22. For example, Duman et al demonstrated that theophylline had beneficial effects on demyelination in a mouse model of peripheral neuropathy.…”
Section: Discussionmentioning
confidence: 99%
“…Transcription factors play a crucial role in spinal cord injury. Recent studies have suggested that transcription factors, such as ATF3 [ 18 , 19 ], Sox11 [ 20 ], STAT3 [ 21 ], and Smad1 [ 22 24 ], are involved in axon regeneration, indicating their potential importance in neuronal functions. The current study aimed to investigate the effects of the transcription factor Ets1, which shows differential expression during spinal cord development, on the axonal growth of neuronal cells.…”
Section: Discussionmentioning
confidence: 99%