2023
DOI: 10.1016/j.pupt.2023.102217
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Transcriptional factor MAZ promotes cisplatin-induced DNA damage repair in lung adenocarcinoma by regulating NEIL3

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Cited by 3 publications
(2 citation statements)
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“…S 6C ), suggesting that IOX1 regulates PIF1 transcriptional expression, possibly in part by indirectly affecting MAZ expression. Previous study showed that MAZ promoted chemoresistance in lung adenocarcinoma cells by inhibiting DNA damage [ 30 ]. Here, we examined the expression of MAZ in NSCLC and found that MAZ was highly expressed in NSCLC compared with normal lung fibroblasts (Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…S 6C ), suggesting that IOX1 regulates PIF1 transcriptional expression, possibly in part by indirectly affecting MAZ expression. Previous study showed that MAZ promoted chemoresistance in lung adenocarcinoma cells by inhibiting DNA damage [ 30 ]. Here, we examined the expression of MAZ in NSCLC and found that MAZ was highly expressed in NSCLC compared with normal lung fibroblasts (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…MAZ, a transcription factor, has been shown to exhibit aberrant expression in various tumor types, playing a role in the regulation of tumor cell proliferation, migration, apoptosis, and autophagy [ 40 ]. In lung cancer, MAZ promotes cisplatin resistance in lung adenocarcinoma cells by inhibiting DNA damage [ 30 ]. In this study, we observed a decrease in the enrichment of MAZ in the distal intergenic region of PIF1 following IOX1 treatment to result the suppression of PIF1 expression.…”
Section: Discussionmentioning
confidence: 99%