2023
DOI: 10.1099/mgen.0.000982
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Transcriptional landscape of Burkholderia pseudomallei cultured under environmental and clinical conditions

Abstract: Burkholderia pseudomallei , a Gram-negative pathogen, is the causative agent of melioidosis in humans. This bacterium can be isolated from the soil, stagnant and salt-water bodies, and human and animal clinical specimens. While extensive studies have contributed to our understanding of B. pseudomallei pathogenesis, little is known about how a harmless soil bacterium adapts when it shi… Show more

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Cited by 3 publications
(1 citation statement)
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“…This could indicate that the lack of protective efficacy in mice may be attributed to the intraperitoneal mouse challenge model employed by the authors. Supportive evidence suggests that the T3SS-3 is expressed at low levels when grown in the lab, but then becomes transcriptionally upregulated when human serum is present, within the environment of the murine lung, or when salt concentrations are high [ 104 , 105 , 106 , 107 ]. This may suggest that the amount of T3SS-3 available for antibody binding during the extracellular phase of infection may be dependent on the initial growth conditions of the bacteria as well as its route of entry into the body.…”
Section: Type 3 Secretion Systemsmentioning
confidence: 99%
“…This could indicate that the lack of protective efficacy in mice may be attributed to the intraperitoneal mouse challenge model employed by the authors. Supportive evidence suggests that the T3SS-3 is expressed at low levels when grown in the lab, but then becomes transcriptionally upregulated when human serum is present, within the environment of the murine lung, or when salt concentrations are high [ 104 , 105 , 106 , 107 ]. This may suggest that the amount of T3SS-3 available for antibody binding during the extracellular phase of infection may be dependent on the initial growth conditions of the bacteria as well as its route of entry into the body.…”
Section: Type 3 Secretion Systemsmentioning
confidence: 99%