Transcriptional modulation of a human monocytic cell line exposed to PM10 from an urban area

Bastonini, Emanuela; Verdone, Loredana; Morrone, Stefania; Santoni, Angela; Settimo, Gaetano; Marsili, Giovanni; Fortezza, Marco La; Mauro, Ernesto Di; Caserta, Micaela

doi:10.1016/j.envres.2011.06.005

Cited by 9 publications

(7 citation statements)

References 64 publications

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“…The effects of air pollution on health have been studied and proven on a global scale. There are many studies that have been carried out to find the correlation of air pollution exposure and mortality, especially in the US and in European countries, and most of them strongly confirm the significant associations between air pollution and mortality [12,[26][27][28]. In the report of WHO as "Review of evidence on health aspects of air pollution-REVIHAAP" Project [29] and "Health risks of air pollution in Europe-HRAPIE" project [30], they illustrated clearly the correlation of air pollution (for PM 10 , PM 2.5 , O 3 and NO 2 ) to human health, interpreted by concentration-response functions.…”

Section: Air Pollution and Health Impact Calculation Methodologymentioning

confidence: 99%

“…Generally, there are many approaches to estimate the health effect from air quality, such as sampling exposure and cell analysis [28], cohort study [32,33], etc. In this research, we applied the second approach by using an impact function relating the levels of air pollution change, the exposure population, the baseline incidence rate and the relative risk coefficient from epidemiological study.…”

Section: Air Pollution and Health Impact Calculation Methodologymentioning

confidence: 99%

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Poor Air Quality and Its Association with Mortality in Ho Chi Minh City: Case Study

Hoang

et al. 2020

Atmosphere

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Along with its rapid urban development, Ho Chi Minh City (HCMC) in recent years has suffered a high concentration of air pollutants, especially fine particulate matters or PM2.5. A comprehensive study is required to evaluate the air quality conditions and their health impact in this city. Given the lack of adequate air quality monitoring data over a large area of the size of HCMC, an air quality modeling methodology is adopted to address the requirement. Here, by utilizing a corresponding emission inventory in combination with The Air Pollution Model-Chemical Transport Model (TAPM-CTM), the predicted concentration of air pollutants is first obtained for PM2.5, NOx, and SO2. Then by associating the pollutants exposed with the mortality rate from three causes, namely Ischemic Heart Disease (IHD), cardiopulmonary, and lung cancer, the impact of air pollution on human health is obtained for this purpose. Spatial distribution has shown a high amount of pollutants concentrated in the central city with a high density of combustion vehicles (motorcycles and automobiles). In addition, a significant amount of emissions can be observed from stevedoring and harbor activities, including ferries and cargo handling equipment located along the river. Other sources such as household activities also contribute to an even distribution of emission across the city. The results of air quality modeling showed that the annual average concentrations of NO2 were higher than the standard of Vietnam National Technical Regulation on Ambient Air Quality (QCVN 05: 2013 40 µg/m3) and World Health Organization (WHO) (40 µg/m3). The annual average concentrations of PM2.5 were 23 µg/m3 and were also much higher than the WHO (10 µg/m3) standard by about 2.3 times. In terms of public health impacts, PM2.5 was found to be responsible for about 1136 deaths, while the number of mortalities from exposure to NO2 and SO2 was 172 and 89 deaths, respectively. These figures demand some stringent measures from the authorities to potentially remedy the alarming situation of air pollution in HCM City.

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Section: Air Pollution and Health Impact Calculation Methodologymentioning

confidence: 99%

Section: Air Pollution and Health Impact Calculation Methodologymentioning

confidence: 99%

Poor Air Quality and Its Association with Mortality in Ho Chi Minh City: Case Study

Hoang

et al. 2020

Atmosphere

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“…Indeed, PM exposure is able to significantly alter the function and responses of platelets both in vitro and in vivo including induction of Ca(2+) release, dense granule secretion and surface expression of platelet activation markers like P‐selectin expression, as well as aggregation, and change in the mean platelet volume 142, 143, 144, 145, 146. Particulate matter exposure/treatment has been shown to modify the function of monocytes significantly including inflammatory response and cytokine production, recruitment and mobilization, and transcriptional and translational modulations of gene expressions in monocytes 135, 136, 147, 148, 149, 150, 151, 152. Further studies are needed to determine the complex relations between PM exposure, monocyte and platelet function, and progenitor cells/SCs.…”

Section: Other Considerationsmentioning

confidence: 99%

Ambient particulate matter exposure and cardiovascular diseases: a focus on progenitor and stem cells

Cui

Sun

Liu

2016

J Cellular Molecular Medi

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Air pollution is a major challenge to public health. Ambient fine particulate matter (PM) is the key component for air pollution, and associated with significant mortality. The majority of the mortality following PM exposure is related to cardiovascular diseases. However, the mechanisms for the adverse effects of PM exposure on cardiovascular system remain largely unknown and under active investigation. Endothelial dysfunction or injury is considered one of the major factors that contribute to the development of cardiovascular diseases such as atherosclerosis and coronary heart disease. Endothelial progenitor cells (EPCs) play a critical role in maintaining the structural and functional integrity of vasculature. Particulate matter exposure significantly suppressed the number and function of EPCs in animals and humans. However, the mechanisms for the detrimental effects of PM on EPCs remain to be fully defined. One of the important mechanisms might be related to increased level of reactive oxygen species (ROS) and inflammation. Bone marrow (BM) is a major source of EPCs. Thus, the number and function of EPCs could be intimately associated with the population and functional status of stem cells (SCs) in the BM. Bone marrow stem cells and other SCs have the potential for cardiovascular regeneration and repair. The present review is focused on summarizing the detrimental effects of PM exposure on EPCs and SCs, and potential mechanisms including ROS formation as well as clinical implications.

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“…During classroom teaching, a large amount of chalk dust particles with an aerodynamic diameter less than 10 μm (PM 10 ) is produced (Majumdar and William 2009;Salma et al 2013). These inhalable particles, which consist of gypsum, calcite (CaCO 3 ), dolomite, and a little amount of organic adhesives (Zhang et al 2015), are small enough to reach conductive airways and the lower respiratory system (Bastonini et al 2011), thereby exerting adverse health effects. It was widely regarded that the hazard effects might be due to oxidative stress and inflammation, which is induced by particles (Zhang et al 2000;Donaldson and Tran 2002;Li et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of coarse chalk dust particles (2.5–10 μm) on respiratory burst and oxidative stress in alveolar macrophages

Zhang

Yang

Feng

et al. 2015

Environ Sci Pollut Res

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The main aim of the present study was to examine in vitro responses of rat alveolar macrophages (AMs) exposed to coarse chalk dust particles (particulate matter in the size range 2.5-10 μm, PM(coarse)) by respiratory burst and oxidative stress. Chalk PM(coarse)-induced respiratory burst in AMs was measured by using a luminol-dependent chemiluminescence (CL) method. Also, the cell viability; lactate dehydrogenase (LDH) release; levels of cellular superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), malondialdehyde (MDA), and acid phosphatase (ACP); plasma membrane ATPase; and extracellular nitric oxide (NO) level were determined 4 h following the treatment with the different dosages of chalk PM(coarse). The results showed that chalk PM(coarse) initiated the respiratory burst of AMs as indicated by strong CL, which was inhibited by diphenyleneiodonium chloride and L-N-nitro-L-arginine methyl ester hydrochloride. It suggested that chalk PM(coarse) induced the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in AMs. This hypothesis was confirmed by the fact that chalk PM(coarse) resulted in a significant decrease of intracellular SOD, GSH, ACP, and ATPase levels and a notable increase of intracellular CAT, MDA content, and extracellular NO level, consequently leading to a decrease of the cell viability and a increase of LDH release. It was concluded that AMs exposed to chalk PM(coarse) can suffer from cytotoxicity which may be mediated by generation of excessive ROS/RNS. Graphical Abstract The possible mechanism of coarse chalk particles-induced adverse effects in AMs.

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Transcriptional modulation of a human monocytic cell line exposed to PM10 from an urban area

Cited by 9 publications

References 64 publications

Poor Air Quality and Its Association with Mortality in Ho Chi Minh City: Case Study

Poor Air Quality and Its Association with Mortality in Ho Chi Minh City: Case Study

Ambient particulate matter exposure and cardiovascular diseases: a focus on progenitor and stem cells

Effects of coarse chalk dust particles (2.5–10 μm) on respiratory burst and oxidative stress in alveolar macrophages

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