Transcriptional regulation of basophil‐specific protease genes by C/EBPα, GATA2, TGF‐β signaling, and epigenetic mechanisms
Ryotaro Tojima,
Kazuki Nagata,
Naoto Ito
et al.
Abstract:Basophils and mast cells (MCs) play an important role in immune responses against allergens and parasitic infection. To elucidate the mechanisms that determine the commitment between basophils and mast cell (MCs), transcription factors and epigenetic modifications regulating the gene expression of basophil‐specific enzymes, Mcpt8 and Mcpt11, were analyzed using bone marrow‐derived (BM) cells containing basophils and MCs. Knockdown (KD) and overexpression experiments revealed that the transcription factor C/EBP… Show more
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