2008
DOI: 10.1016/j.fgb.2007.09.005
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Transcriptional regulation of genes on the non-syntenic blocks of Aspergillus oryzae and its functional relationship to solid-state cultivation

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Cited by 43 publications
(36 citation statements)
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“…This method assumes that all essential genes exist in homologous form in all genomes and all nonessential genes will be absent in one or more cases. Based on this theory, we focused mainly on NSBs, which were identified by comparison of the A. oryzae genome with those of A. fumigatus and A. nidulans (20). We predicted that the deletion of these A. oryzae-specific regions would have no significant impact on growth rate and other phenotypic changes.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This method assumes that all essential genes exist in homologous form in all genomes and all nonessential genes will be absent in one or more cases. Based on this theory, we focused mainly on NSBs, which were identified by comparison of the A. oryzae genome with those of A. fumigatus and A. nidulans (20). We predicted that the deletion of these A. oryzae-specific regions would have no significant impact on growth rate and other phenotypic changes.…”
Section: Discussionmentioning
confidence: 99%
“…We focused on chromosome 7 which contains a large number of nonsyntenic blocks (NSBs). These NSBs were detected by comparison of the A. oryzae genome with those of Aspergillus fumigatus and Aspergillus nidulans, and they contain abundant genes involved in secondary metabolism and A. oryzae-specific genes (20). Analysis of chromosome 7 deletions identified a novel gene that has been predicted to encode a basic helix-loop-helix (bHLH) protein on the basis of its conserved motif.…”
mentioning
confidence: 99%
“…DNA microarray experiments were performed as described previously (Tamano et al, 2008). Two cDNA samples labeled with Cy5 and Cy3 for each were mixed and applied onto 12 K A. oryzae oligonucleotide microarrays (Fermlab/NovusGene, Tokyo, Japan) for hybridization.…”
Section: Mrna Preparation and Dna Microarray Experimentsmentioning
confidence: 99%
“…These data seem to indicate that a large number of metabolites are present and actually await their discovery and structural elucidation. On the other hand transcriptional inventories of Ascomycetes carried out have provided evidence that many secondary metabolite genes have not been expressed under the respective cultivation conditions, and even shifts of conditions like solid-state fermentation did not lead to the expression of complex metabolite genes (Tamano et al, 2008). Molecular genetic genome mining approaches so far have utilized gene disruption approaches (Chiang et al, 2008) or the manipulation of transcriptional regulators (Bok and Keller 2004;Bok et al, 2006).…”
Section: Introductionmentioning
confidence: 99%