Transcriptional regulation of IL-17A and other inflammatory markers during the development of soybean meal-induced enteropathy in the distal intestine of Atlantic salmon (Salmo salar L.)

Marjara, Inderjit S.; Chikwati, Elvis; Valen, Elin C.; Krogdahl, Åshild; Bakke, Anne Marie

doi:10.1016/j.cyto.2012.05.027

Cited by 126 publications

(109 citation statements)

References 61 publications

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“…A comprehensive approach was used, assessing fish zootechnical performance, plasma cholesterol levels and intestinal histomorphology. Gene expression profiling was also performed based on recent studies that identified several potential markers for diet-induced enteropathy, including genes related to inflammatory cytokines, intestinal barrier function and nutrient transporters (Skugor et al, 2011;Kortner et al, 2012;Marjara et al, 2012;Sahlmann et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary soy saponins and phytosterols on gilthead sea bream (Sparus aurata) during the on-growing period

Couto

Kortner

Penn

et al. 2014

Animal Feed Science and Technology

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Section: Introductionmentioning

confidence: 99%

Effects of dietary soy saponins and phytosterols on gilthead sea bream (Sparus aurata) during the on-growing period

Couto

Kortner

Penn

et al. 2014

Animal Feed Science and Technology

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“…IL-17D is important in local immune responses and repair of tissues after structural damage (Starnes et al, 2002). il17a and tfgb were upregulated in the intestine of Atlantic salmon during the early and/or late inflammatory stages (Marjara et al, 2012), and il1b was reduced after recovery from inflammation (Vasanth et al, 2015). Oral intubation of 10 mg of A. platensis suspension per carp (C. carpio) increased the phagocytic activity, superoxide anion production, il1b and tnfa, but decreased il10 in head kidney leukocytes (Watanuki et al, 2006).…”

Section: Health Status Upon Feeding Desmodesmus To Atlantic Salmonmentioning

confidence: 99%

“…In the present study, the expression of il1b, tnfa, il17a and il10 were below the detection limit. Marjara et al (2012) reported the low expression of certain genes including tnfa in the distal intestine of Atlantic salmon. In the present study, the mRNA levels of tgfb and il17d of the algal groups were similar to those of the control fish.…”

Section: Health Status Upon Feeding Desmodesmus To Atlantic Salmonmentioning

confidence: 99%

Defatted Biomass of the Microalga, Desmodesmus sp., Can Replace Fishmeal in the Feeds for Atlantic salmon

et al. 2016

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Microalgal biomass is a potential feed ingredient that can replace fishmeal and ensure sustainability standards in aquaculture. To understand the efficacy of the defatted biomass from the marine microalga, Desmodesmus sp. a 70-day feeding study was performed with Atlantic salmon (Salmo salar) smolts. Three groups of fish (av. wt. 167 g) were offered either a control feed (without the microalga) or the microalga-containing (10/20%) feeds. At the end of the feeding period, the growth indices (condition factor, specific growth rate) and survival of the microalga-fed fish were not significantly different from the respective values of the control fish, but the feed conversion ratios were inferior. The proximate composition of the whole body of salmon from the three groups did not vary significantly. Compared to the control fish, the 10% alga-fed fish had lower lipid content in their filet. The protein and lipid digestibility in the three feeds did not differ significantly, but the digestibility of energy in the 10% alga-feed was significantly lower than that of the control feed. Furthermore, comparison of the distal intestinal proteome of Atlantic salmon revealed that the expressions of Alpha-2-HS-glycoprotein-like (Ahsg), Myosin-11 isoform X1 (My11) and Dihydrolipoyl dehydrogenase, mitochondrial-like (Dld) were altered by the microalgal feeding. Examination of the physiological status of the fish based on the serum antioxidant capacities did not reveal any alga-feed-related differences. Moreover, the expression of the selected immune and inflammatory marker genes and the micromorphological observations did not indicate any aberration in the intestinal health of the microalga-fed fish. It is possible to include 20% of defatted Desmodesmus sp. in the feeds of Atlantic salmon.

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“…Previous papers have shown induction of enteritis and significant impact on the immune response in the gut of salmonid fish on plant-based diets (Marjara et al, 2012;Uran et al, 2009). These responses seem to being linked mainly to the proteins from the plants rather than the oil .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The development of the gut microbiota in rainbow trout (Oncorhynchus mykiss) is affected by first feeding and diet type

et al. 2014

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Archived at http://orgprints.org/24967 AbstractAn influence of the intestinal microbiota in connection to first-feeding of rainbow trout (Oncorhynchus mykiss) fry was demonstrated using Illumina HiSeq sequencing. The period from the end of yolk-sac feeding and until seven weeks post first-feeding was examined after administration of either a marine-or plant based diet with or without the probiont Pediococcus acidilactici. Before first feeding the main part of the sequence reads grouped to the genus Sediminibacterium probably originating from the surrounding water. The microbial abundance and diversity increased after first-feeding and the microbiota then changed towards Firmicutes phylum dominance for plant based fed fish and towards dominance of phylum Proteobacteria for the marine fed fish. After first-feeding, there were significantly higher abundances of Streptococcus, Leuconostoc and Weissella in fish fed the plant-based diet. The microbiota clustered separately according to the diet type, but only minor effects were seen from the probiont when using PCAanalysis. The constitutive transcription level of most examined immune genes increased during the ontogenic shift, but the results could not explain the differences in the composition of the A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT2 microbiota dependent on diet treatment after first-feeding. The results suggest that the intestine of rainbow trout is colonised at an early state, but is guided in new and different directions dependent on the diet type.

show abstract

Transcriptional regulation of IL-17A and other inflammatory markers during the development of soybean meal-induced enteropathy in the distal intestine of Atlantic salmon (Salmo salar L.)

Cited by 126 publications

References 61 publications

Effects of dietary soy saponins and phytosterols on gilthead sea bream (Sparus aurata) during the on-growing period

Effects of dietary soy saponins and phytosterols on gilthead sea bream (Sparus aurata) during the on-growing period

Defatted Biomass of the Microalga, Desmodesmus sp., Can Replace Fishmeal in the Feeds for Atlantic salmon

The development of the gut microbiota in rainbow trout (Oncorhynchus mykiss) is affected by first feeding and diet type

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