Transcriptional regulation of T-bet, GATA3, ROR&lt;gamma&gt;T, HERV-K env, Syncytin-1, microRNA-9, 192 and 205 induced by nisin in colorectal cancer cell lines (SW480, HCT116) and human peripheral blood mononuclear cell

Tavakoli, Shayan; Gholami, Milad; Ghorban, Khodayar; Nojoumi, Farshad; Faghihloo, Ebrahim; Dadmanesh, Maryam; Rouzbahani, Negin Hosseini

doi:10.1016/j.genrep.2021.101025

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…Hosseini and co-workers reported a significant decrease in the growth rate of SW480 colorectal cancer cell line after being treated with nisin [211]. Similar conclusions are reported by Tavakoli et al [212]. Nisin also showed a significant efficiency as an adjuvant to conventional chemotherapeutic agents.…”

Section: Applicationssupporting

confidence: 70%

Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine

Jančič

Gorgieva

2021

Pharmaceutics

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Infectious diseases along with various cancer types are among the most significant public health problems and the leading cause of death worldwide. The situation has become even more complex with the rapid development of multidrug-resistant microorganisms. New drugs are urgently needed to curb the increasing spread of diseases in humans and livestock. Promising candidates are natural antimicrobial peptides produced by bacteria, and therapeutic enzymes, extracted from medicinal plants. This review highlights the structure and properties of plant origin bromelain and antimicrobial peptide nisin, along with their mechanism of action, the immobilization strategies, and recent applications in the field of biomedicine. Future perspectives towards the commercialization of new biomedical products, including these important bioactive compounds, have been highlighted.

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Section: Applicationssupporting

confidence: 70%

Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine

Jančič

Gorgieva

2021

Pharmaceutics

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“…In addition, Lactococcus lactis can produce nisin, which has been shown to inhibit cancer cell development by altering gene expression when added to food, but this requires further investigation 17 . The growth rate of cancer cells treated with nisin decreased significantly compared to those treated with the other two substances, namely cytoplasmic extract and cell wall ( P <0.05).…”

Section: Discussionmentioning

confidence: 99%

Effects of Lactococcus lactis on colorectal cancer in various terms: a narrative review

Rivai,

Lusikooy,

Putra

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction: Colorectal cancer is one of the most common cancers with an increasing number of cases. Various studies have found an association between the gut microbiota balance and colorectal cancer incidence. Lactococcus lactis is a probiotic bacterium found in fermented foods, particularly yogurt and cheese. This probiotic has been shown to reduce various anti-inflammatory and pro-inflammatory agents that trigger cancer, such as IL-6, IL-18, TNF-α, and NK cells. Methods: Full-text articles and original research published in the last ten years were used as references, and “Lactococcus and colorectal cancer” as keywords. The reference search is on several databases, such as PubMed, ScienceDirect, ProQuest, and Nature. Searching results obtained eleven articles. Discussion: Lactococcus lactis does have a perfect role in suppressing cancer cells. Lactococcus lactis has anti-proliferative effects associated with decreased cyclin D1 expression in SW480 cell lines, decreased NK cells, reduced cancer cell viability, decreased IL-8 levels, and decreased IL-6. Conclusion: Lactococcus lactis contains nisin, which can suppress various gene, protein, and cytokine expressions that play a role in cancer cell growth. Probiotics can inhibit colorectal cancer without significant side effects.

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Association of HLA alleles with hematologic malignancies

et al. 2021

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Transcriptional regulation of T-bet, GATA3, ROR<gamma>T, HERV-K env, Syncytin-1, microRNA-9, 192 and 205 induced by nisin in colorectal cancer cell lines (SW480, HCT116) and human peripheral blood mononuclear cell

Cited by 5 publications

References 41 publications

Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine

Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine

Effects of Lactococcus lactis on colorectal cancer in various terms: a narrative review

Association of HLA alleles with hematologic malignancies

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