Transcriptional regulatory network of high-value active ingredients in medicinal plants

Zheng, Han; Fu, Xueqing; Shao, Jin; Tang, Yueli; Yu, Muyao; Li, Ling; Huang, Luqi; Tang, Kexuan

doi:10.1016/j.tplants.2022.12.007

Cited by 77 publications

(25 citation statements)

References 157 publications

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“…In addition, elicitors signaling mechnisms have a significant impact on bioactivities, mitigation of environmental stress, plant survivability and productivity (Jan et al 2021). Several phytohormones (Sabagh et al 2022), transcription factors (TFs) (Zheng et al 2023) and enzymes (Rajput et al 2021) associated with various biological pathways, cell compartmentalization and ion exchange play a major role in the development of a signal transduction network. Furthermore, several TFs such as MYB, WRKY, bHLH and AP2/ ERF are actively involved in hormonal signaling pathways to enhance the pharamaceutically active phytocompounds in various medicinal plants (Jan et al 2021;Zheng et al 2023).…”

Section: Introductionmentioning

confidence: 99%

“…Several phytohormones (Sabagh et al 2022), transcription factors (TFs) (Zheng et al 2023) and enzymes (Rajput et al 2021) associated with various biological pathways, cell compartmentalization and ion exchange play a major role in the development of a signal transduction network. Furthermore, several TFs such as MYB, WRKY, bHLH and AP2/ ERF are actively involved in hormonal signaling pathways to enhance the pharamaceutically active phytocompounds in various medicinal plants (Jan et al 2021;Zheng et al 2023). During the elicitation process, there are some types of parameters such as concentration, time exposure, elicitor type, and cell culture type that decide the accumulation and enhanced synthesis of metabolite production in plants (Dhiman et al 2018).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Methyl jasmonate and salicylic acid as powerful elicitors for enhancing the production of secondary metabolites in medicinal plants: an updated review

Jeyasri

Muthuramalingam

Karthick

et al. 2023

Plant Cell Tiss Organ Cult

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Plant secondary metabolites are bioactive scaffolds that are crucial for plant survival in the environment and to maintain a defense mechanism from predators. These compounds are generally present in plants at a minimal level and interestingly, they are found to have a wide variety of therapeutic values for humans. Several medicinal plants are used for pharmaceutical purposes due to their affordability, fewer adverse effects, and vital role in traditional remedies. Owing to this reason, these plants are exploited at a high range worldwide and therefore many medicinal plants are on the threatened list. There is a need of the hour to tackle this major problem, one effective approach called elicitation can be used to enhance the level of existing and novel plant bioactive compounds using different types of elicitors namely biotic and abiotic. This process can be generally achieved by in vitro and in vivo experiments. The current comprehensive review provides an overview of biotic and abiotic elicitation strategies used in medicinal plants, as well as their effects on secondary metabolites enhancement. Further, this review mainly deals with the enhancement of biomass and biosynthesis of different bioactive compounds by methyl jasmonate (MeJA) and salicylic acid (SA) as elicitors of wide medicinal plants in in vitro by using different cultures. The present review was suggested as a significant groundwork for peers working with medicinal plants by applying elicitation strategies along with advanced biotechnological approaches.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methyl jasmonate and salicylic acid as powerful elicitors for enhancing the production of secondary metabolites in medicinal plants: an updated review

Jeyasri

Muthuramalingam

Karthick

et al. 2023

Plant Cell Tiss Organ Cult

View full text Add to dashboard Cite

show abstract

“…These findings offer significant insights into the evolution of clerodane biosynthetic pathways in the mint family, Lamiaceae, and will facilitate the production of anticancer clerodanes through future metabolic engineering endeavors. In another review by Zheng et al, [88] the transcriptional regulation modes of biosynthetic pathways for various high-value active ingredients in Artemisia annua , Salvia miltiorrhiza , Catharanthus roseus , Taxus wallichiana , and Panax ginseng are examined from the perspectives of environmental factors and hormone signals. The review concludes that the “environmental factors–hormone signals–transcription factors–active ingredient” regulatory network, along with its associated research methods, plays a crucial role.…”

Section: Biological Essence and Inspirationmentioning

confidence: 99%

“…Transcriptional regulatory network of active ingredients and multi-omics integration in medical plants. [88] (A) 'Omics data and molecular biology technology can be used to decipher the molecular mechanism of transcriptional regulation of active ingredients. (B) The transcriptional regulatory network of active ingredients is the most important tie between the production and environment in medical plants.…”

Section: Biological Essence and Inspirationmentioning

confidence: 99%

Theory and scientificity of traditional Chinese medicine

Guo,

Zhang,

Huang

2023

Sci Tradit Chin Med

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The Nobel Prize for artemisinin and the COVID-19 pandemic have heightened interest in the disease prevention and treatment of traditional Chinese medicine (TCM). However, uncertainty and misinformation remain about some key issues. Herein, we discuss the current literature showing that, despite TCM gaining recognition, the theoretical systems of TCM and Western medicine rooted in different cultural backgrounds have huge differences in their theories and treatments. How to achieve accurate diagnosis in TCM, how to give scientific treatment, what is the mechanism of treatment, and what are the effect and safety of treatment, all need to be more clearly explained and require high-quality modern scientific evidence. An emerging consensus exists that, with the help of modern technology and scientific methods, it is necessary to excavate the essence of TCM that truly conforms to the laws of human life movement and disease development, realize cross-complementation with Western medicine, enhance human understanding of diseases, enrich diagnosis and treatment methods, and promote a new level in the field of life sciences.

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“…Due to the diversity of PSMs in different plant species, biosynthesis and regulation of PSMs are not fully elucidated. Moreover, most of the PSMs are low in content and metabolic engineering has been used to boost the production of valuable PSMs ( Verpoorte and Memelink, 2002 ; Zheng et al., 2023 ). This Research Topic presents the most recent advances in 26 publications, including 4 reviews and 22 research articles, contributed by 197 authors.…”

Section: Introductionmentioning

confidence: 99%

Editorial: Plant secondary metabolic regulation and engineering

Zhang

Liu

2023

Front. Plant Sci.

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Editorial on the Research TopicPlant secondary metabolic regulation and engineering Identification of key pathway genes of PSMsAlthough the value of specific PSMs, their biosynthetic and metabolic pathways are not fully illustrated. In this topic, several candidate genes for the biosynthesis of diterpenoids (ATDs) and phenolic acids (PAs) were identified in the medicinal plant Salvia apiana and its close species S. miltiorrhiza (Hu et al.). In this study, comparative metabolome and transcriptome analyses between S. apiana roots and leaves, and between two species Frontiers in Plant Science frontiersin.org 01

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Transcriptional regulatory network of high-value active ingredients in medicinal plants

Cited by 77 publications

References 157 publications

Methyl jasmonate and salicylic acid as powerful elicitors for enhancing the production of secondary metabolites in medicinal plants: an updated review

Methyl jasmonate and salicylic acid as powerful elicitors for enhancing the production of secondary metabolites in medicinal plants: an updated review

Theory and scientificity of traditional Chinese medicine

Editorial: Plant secondary metabolic regulation and engineering

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