Transcriptional Repression by Blimp-1 (PRDI-BF1) Involves Recruitment of Histone Deacetylase

Yu, Jin Chen; Angelin-Duclos, Cristina; Greenwood, Jessica; Liao, Jingqiu; Calame, Kathryn

doi:10.1128/mcb.20.7.2592-2603.2000

Cited by 308 publications

(297 citation statements)

References 70 publications

(119 reference statements)

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“…Innate immune factors such as IL2 can induce the expression of Prdm1; Prdm1 represses IL2 expression in turn and initiates leukocyte development in mouse [60]. Perhaps Prdm1a play the same role in the immune system of fish as its homologues in mammal to induce development of B, T and NK cells [2,3,5,[8][9][10][11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…The repression activity of Prdm1 is needed for development and maturation of lymphoid cells in the mammal [2,3,5,[8][9][10][11][12][13][14][15][16][17]. Mammal Prdm1 inhibits the expression of genes such as IL-2, c-Fos, ifng, tbx21 and bcl6 [60,61].…”

Section: Discussionmentioning

confidence: 99%

“…Prdm1 was first described as a protein binding to the beta-interferon promoter and repressing beta-interferon expression [1], and later was identified as a protein which being expressed upon differentiation of B lymphocytes to plasma cells and importantly, playing major role in activation of mature B cells and differentiation of B cells into plasma cells [2][3][4][5][6][7]. Prdm1-induced maturation of lymphocytes is correlated with the ability of Prdm1 to repress numbers of genes critical for mature B cell identity and cellular proliferation [5,[8][9][10][11][12][13]. Prdm1 is also needed for the activation of T cells [14][15][16][17][18], the differentiation of myeloid lineage [19] and the maturation of nature killer (NK) cells [20].…”

Section: Introductionmentioning

confidence: 99%

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Identification and expression profiles of prdm1 in medaka Oryzias latipes

et al. 2013

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Mouse Prdm1, also known as Blimp1, plays important roles in maturation and survival of lymphoid cells, as well as in organogenesis of muscle, limb, sensor organs and primordial germ cells. The homologues of mouse prdm1 have been identified in a diverse of animals including zebrafish and fugu. Here, we report the identification and expression profiles of two homologues of prdm1, namely prdm1a and prdm1b in medaka, Oryzias latipes. The transcripts of prdm1a and prdm1b were detectable in all the tissues including immune organs such as gill, spleen, kidney, liver and intestine that we have checked on. The transcripts of prdm1a could be detected in the embryonic shield at mid-gastrula stage and later in the somite, eye, otic vesicle, branchial arches, fin, intestine and cloaca during embryogenesis using in situ hybridization. Moreover, the expression of prdm1a in the liver of both medaka and zebrafish could be up-regulated by the immune stimuli including lipopolysaccharide, polyI:C and the grass carp reovirus, similarly to the up-regulation of IL1B. These results indicate that Prdm1a may play important roles in embryogenesis and also in immune response in fish.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Identification and expression profiles of prdm1 in medaka Oryzias latipes

et al. 2013

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“…Inhibition of CIITA transcription could be mediated by a repressor that recruits HDACs to the CIITA promoter, analogous to the repression mediated by HDAC recruitment by nuclear receptors, the Mad/Max and Rb-E2F complexes, and by the methyl-CpG-binding proteins (15,16). A likely candidate is the Blimp-1 transcriptional repressor, a regulator of terminal B cell differentiation that has been shown to associate with HDACs (41). The surface expression of class II on TSA-treated J558 cells is high, approaching that on B cells and IFN-␥ inducible cells; compared with the relatively low levels found in the CIITA-negative MC and Colon 26 cells.…”

Section: Discussionmentioning

confidence: 99%

Activation of MHC Class I, II, and CD40 Gene Expression by Histone Deacetylase Inhibitors

Magner¹,

Kazim

Stewart

et al. 2000

The Journal of Immunology

270

224

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Epigenetic mechanisms are involved in regulating chromatin structure and gene expression through repression. In this study, we show that histone deacetylase inhibitors (DAIs) that alter the acetylation of histones in chromatin enhance the expression of several genes on tumor cells including: MHC class I, II, and the costimulatory molecule CD40. Enhanced transcription results in a significant increase in protein expression on the tumor cell surface, and expression can be elicited on some tumors that are unresponsive to IFN-γ. The magnitude of induction of these genes cannot be explained by the effect of DAIs on the cell cycle or enhanced apoptosis. Induction of class II genes by DAIs was accompanied by activation of a repressed class II transactivator gene in a plasma cell tumor but, in several other tumor cell lines, class II was induced in the apparent absence of class II transactivator transcripts. These findings also suggest that the abnormalities observed in some tumors in the expression of genes critical to tumor immunity may result from epigenetic alterations in chromatin and gene regulation in addition to well-established mutational mechanisms.

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“…The SET domain is thought to confer histone lysine methyltransferase activity on the protein 18 and has been shown to repress transcription of the genes MYC 19 , IFNB1 (ref. 20) and MHC2TA 21 by binding to their promoters and recruiting the corepressors Groucho 22 and histone deacetylase 23 .…”

Section: Methodsmentioning

confidence: 99%