2012
DOI: 10.1371/journal.pone.0048954
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Transcriptional Repression of E-Cadherin by Human Papillomavirus Type 16 E6

Abstract: There is increasing evidence supporting DNA virus regulation of the cell adhesion and tumour suppressor protein, E-cadherin. We previously reported that loss of E-cadherin in human papillomavirus (HPV) type 16-infected epidermis is contributed to by the major viral proto-oncogene E6 and is associated with reduced Langerhans cells density, potentially regulating the immune response. The focus of this study is determining how the HPV16 E6 protein mediates E-cadherin repression. We found that the E-cadherin promo… Show more

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Cited by 78 publications
(55 citation statements)
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References 52 publications
(66 reference statements)
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“…This finding is similar to that of a previous study showing that the HPV-16 E6 protein induces E-cadherin repression and that the E-cadherin promoter is repressed in cells expressing E6, causing reduced E-cadherin transcription (26).…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…This finding is similar to that of a previous study showing that the HPV-16 E6 protein induces E-cadherin repression and that the E-cadherin promoter is repressed in cells expressing E6, causing reduced E-cadherin transcription (26).…”
Section: Discussionsupporting
confidence: 91%
“…Moreover, HPV-16 E6-expressing cells show a greater reduction in E-cadherin expression than HPV-16 E7-expressing cells, and our data suggest that HPV-16 E6 is es-sential for reducing E-cadherin expression and inducing EMT (26).…”
Section: Discussionsupporting
confidence: 49%
“…Our results are in accord with those of previous in vitro studies showing that E7 and E6 HPV proteins may trigger E-cadherin down-regulation in keratinocyte cultures. 19 HPV induced loss of E-cadherin expression in PSCC could also be due to HPV related loss of chromosome 16q, which harbors the E-cadherin gene, as reported in oral squamous cell carcinoma. 20 In contrast, we found no association between HPV and EMT.…”
Section: Discussionmentioning
confidence: 67%
“…E- cadherin is reduced in both high and low grade lesions in vivo as well as in vitro organotypic models 154,293,294,296,297,322,323 . High risk E6 and E7 downregulate E-cadherin and do so through several mechanisms 42,151,156,158,296,324,325 . Downregulation of E-cadherin is also seen in lesions caused by low risk HPV types 297 .…”
Section: Immune Interactionsmentioning
confidence: 99%