Transcriptional repression of the human fibronectin gene in laryngeal squamous cell carcinoma cells

Görögh, Tibor; Maune, Steffen; Lippert, B. M.; Rudert, H.; Gottschlich, S.; Hoffmann, Markus; Meyer, Jens E.; Heidorn, Klaus; Werner, Jochen A.

doi:10.1007/s004320000198

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Upregulation of CCR4 and downregulation of FN1 could increase the migratory and metastatic capacities of lung tumor cells. CCR4 has previously been demonstrated to be essential for metastasis of lung tumor cells in the bone marrow (51), and fibronectin is frequently downregulated in cancer, which is thought to be a factor underlying metastatic behavior (52). In some experimental conditions, we also observed upregulation of the proinflammatory cytokines IL-6, IL-8, CSF-2, IL-1α, and…”

Section: Figuresupporting

confidence: 54%

Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance

Cherfils‐Vicini¹,

Platonova²,

Gillard³

et al. 2010

J. Clin. Invest.

200

178

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Compelling evidence suggests that inflammation, cell survival, and cancer are linked, with a central role played by NF-κB. Recent studies implicate some TLRs in tumor development based on their ability to facilitate tumor growth; however, to our knowledge, involvement of neither TLR7 nor TLR78 has yet been demonstrated. Here we have demonstrated expression of TLR7 and TLR8, the natural receptors for single-stranded RNA, by tumor cells in human lung cancer in situ and in human lung tumor cell lines. Stimulation with TLR7 or TLR8 agonists led to activated NF-κB, upregulated expression of the antiapoptotic protein Bcl-2, increased tumor cell survival, and chemoresistance. Transcriptional analysis performed on human primary lung tumor cells and TLR7-or TLR8-stimulated human lung tumor cell lines revealed a gene expression signature suggestive of chronic stimulation of tumor cells by TLR ligands in situ. Together, these data emphasize that TLR signaling can directly favor tumor development and further suggest that researchers developing anticancer immunotherapy using TLR7 or TLR8 agonists as adjuvants should take into account the expression of these TLRs in lung tumor cells.

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Section: Figuresupporting

confidence: 54%