Transcriptional response in rainbow trout (Oncorhynchus mykiss) B cells and thrombocytes following in vivo exposure to benzo[a]pyrene

Phalen, Laura J.; Köllner, Bernd; Hogan, Natacha S.; Heuvel, Michael R. van den

doi:10.1016/j.etap.2017.06.002

Cited by 14 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence that the AhR pathway is functional comes from the fact that a key target gene of the AhR, CYP1A, can be upregulated in fish immune cells treated with AhR ligands. This has been shown in a number of in vivo stud-ies when fishes exposed to compounds, such as TCDD or BaP, showed increased CYP1A immunoreactivity and/or CYP1A mRNA in immune cells [151,152,[157][158][159][160]. Additionally, in vitro studies with isolated fish leukocytes show that exposure to AhR ligands results in CYP1A induction in these cells [146,150].…”

Section: The Presence and Xenobiotic Inducibility Of The Ahr In Immune Organs And Cells Of Teleost Fishmentioning

confidence: 75%

“…This finding would agree with the FISH data of Song et al [146] on AhR cellular distribution. Phalen et al [152] applied FACS sorting of rainbow trout immune cell populations, and found that AhR and CYP1A mRNA were expressed in B cells of blood, spleen, and head kidney as well as in thrombocytes of blood and spleen. Thrombocytes in fishes are nucleated cells with a primary role in blood clotting, but they appear to play a role also in the immune defense, for instance, they express genes involved in antigen presentation and they are active in phagocytosis [152][153][154].…”

Section: The Presence and Xenobiotic Inducibility Of The Ahr In Immune Organs And Cells Of Teleost Fishmentioning

confidence: 99%

“…Further immunological functions of fish that were impacted by AhR ligands including B cell functioning [188,220,221], bactericidal activity [205,222], leukocyte leukotriene secretion [155], and cytotoxic cell activity [222,223]. In addition, humoral immune parameters of fish, such as lysozyme activity, antibody levels, or complement activities, were modulated by exposure to AhR-binding xenobiotics or environmental matrices containing AhR ligands [152,192,217,[223][224][225]. Generally, the toxicants had suppressive effects on the measured immune functions, although exceptions exist.…”

Section: Immune Functional Responses Of Fish To Ahr-binding Xenobioticsmentioning

confidence: 99%

See 2 more Smart Citations

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

Segner

Bailey²,

Tafalla³

et al. 2021

IJMS

View full text Add to dashboard Cite

The impact of anthropogenic contaminants on the immune system of fishes is an issue of growing concern. An important xenobiotic receptor that mediates effects of chemicals, such as halogenated aromatic hydrocarbons (HAHs) and polyaromatic hydrocarbons (PAHs), is the aryl hydrocarbon receptor (AhR). Fish toxicological research has focused on the role of this receptor in xenobiotic biotransformation as well as in causing developmental, cardiac, and reproductive toxicity. However, biomedical research has unraveled an important physiological role of the AhR in the immune system, what suggests that this receptor could be involved in immunotoxic effects of environmental contaminants. The aims of the present review are to critically discuss the available knowledge on (i) the expression and possible function of the AhR in the immune systems of teleost fishes; and (ii) the impact of AhR-activating xenobiotics on the immune systems of fish at the levels of immune gene expression, immune cell proliferation and immune cell function, immune pathology, and resistance to infectious disease. The existing information indicates that the AhR is expressed in the fish immune system, but currently, we have little understanding of its physiological role. Exposure to AhR-activating contaminants results in the modulation of numerous immune structural and functional parameters of fish. Despite the diversity of fish species studied and the experimental conditions investigated, the published findings rather uniformly point to immunosuppressive actions of xenobiotic AhR ligands in fish. These effects are often associated with increased disease susceptibility. The fact that fish populations from HAH- and PAH-contaminated environments suffer immune disturbances and elevated disease susceptibility highlights that the immunotoxic effects of AhR-activating xenobiotics bear environmental relevance.

show abstract

Section: The Presence and Xenobiotic Inducibility Of The Ahr In Immune Organs And Cells Of Teleost Fishmentioning

confidence: 75%

Section: The Presence and Xenobiotic Inducibility Of The Ahr In Immune Organs And Cells Of Teleost Fishmentioning

confidence: 99%

Section: Immune Functional Responses Of Fish To Ahr-binding Xenobioticsmentioning

confidence: 99%

See 1 more Smart Citation

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

Segner

Bailey²,

Tafalla³

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…An important cancer research objective is to develop therapeutic agents that specifically target tumor cells. Studies have found that P450s provide therapeutic options at higher levels in tumor cells compared to that in the surrounding tissues due to activation of the prodrugs in the cancer cells, which reduces side effects [20,132]. As a result, there are opportunities for enhanced tumor-specific endogenous expression of P450s and CYP-mediated gene therapy.…”

Section: Role Of P450s In Chemotherapymentioning

confidence: 99%

The Multifarious Link between Cytochrome P450s and Cancer

Alzahrani

2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an important role in the metabolism of endogenous as well as exogenous substances, especially drugs. Moreover, many P450s can serve as targets for disease therapy. Increasing reports of epidemiological, diagnostic, and clinical research indicate that P450s are enzymes that play a major part in the formation of cancer, prevention, and metastasis. The purposes of this review are to shed light on the current state of knowledge about the cancer molecular mechanism involving P450s and to summarize the link between the cancer effects and the participation of P450s.

show abstract