Transcriptional response to alcohol exposure in Drosophila melanogaster

Morozova, Tatiana V.; Anholt, Robert R. H.; Mackay, Trudy F. C.

doi:10.1186/gb-2006-7-10-r95

Cited by 92 publications

(66 citation statements)

References 36 publications

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“…Opioids in mammals either reduce or enhance locomotor activity, depending on dose and time protocols (Timára et al, 2005; Zhao et al, 2004). Parallels to the general phenomena of acute response, tolerance, withdrawal and sensitization have been identified in many mammals (Morgan and Sedensky, 1995; Singh and Heberlein, 2000; Schafer, 2004; Scholz, 2005; Nichols, 2006; Morozova et al, 2006; Raffa et al, 2006; Feng et al, 2006). …”

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confidence: 94%

Drug-sensitive reward in crayfish: An invertebrate model system for the study of SEEKING, reward, addiction, and withdrawal

Huber

Panksepp

Nathaniel

et al. 2011

Neuroscience & Biobehavioral Reviews

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In mammals, rewarding properties of drugs depend on their capacity to activate appetitive motivational states. With the underlying mechanisms strongly conserved in evolution, invertebrates have recently emerged as a powerful new model in addiction research. In crayfish natural reward has proven surprisingly sensitive to human drugs of abuse, opening an unlikely avenue of research into the basic biological mechanisms of drug addiction. In a series of studies we first examined the presence of natural reward systems in crayfish, then characterized its sensitivity to a wide range of human drugs of abuse. A conditioned place preference (CPP) paradigm was used to demonstrate that crayfish seek out those environments that had previously been paired with the psychostimulants cocaine and amphetamine, and the opioid morphine. The administration of amphetamine exerted its effects at a number of sites, including the stimulation of circuits for active exploratory behaviors (i.e., SEEKING). A further study examined morphineinduced reward, extinction and reinstatement in crayfish. Repeated intra-circulatory infusions of morphine served as a reward when paired with distinct visual or tactile cues. Morphine-induced CPP was extinguished after repeated saline injections. Following this extinction phase, morphineexperienced crayfish were once again challenged with the drug. The priming injections of morphine reinstated CPP at all tested doses, suggesting that morphine-induced CPP is unrelenting. In an exploration of drug-associated behavioral sensitization in crayfish we concurrently mapped measures of locomotion and rewarding properties of morphine. Single and repeated intra-✩ Studies reported in this paper were supported by a grant to R.H. and J.P. (NIH/NIDA 1R21DA016435-01A1) and by the help of Hope for Depression Research Foundation to J.P.

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confidence: 94%

Drug-sensitive reward in crayfish: An invertebrate model system for the study of SEEKING, reward, addiction, and withdrawal

Huber

Panksepp

Nathaniel

et al. 2011

Neuroscience & Biobehavioral Reviews

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“…Morozova et al , (2006, 2007, 2009, 2011) conducted a variety of creative transcriptome analysis studies. Each publication probes alcohol responsivity in a different way.…”

Section: Genomic Analyses Of Alcohol Responses In Fliesmentioning

confidence: 99%

“…Gene candidates and gene networks were validated using mutants or RNAi knockdown. This group began looking at transcriptome changes following each ethanol treatment (Morozova et al , 2006) and then at gene expression differences between fly lines bred for ethanol resistance or sensitivity for 35 generations (Morozova et al , 2007). In 2009, this was followed up by examining the basal (ethanol-naive) gene expression profile of 40 wild-derived inbred lines (Morozova et al , 2009).…”

Section: Genomic Analyses Of Alcohol Responses In Fliesmentioning

confidence: 99%

Genetics and genomics of alcohol responses in Drosophila

et al. 2017

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Drosophila melanogaster has become a significant model organism for alcohol research. In flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol responses and adaptations. Furthermore, almost all genes can be easily genetically manipulated. Despite the great evolutionary distance between flies and mammals, many of the same genes have been implicated in strikingly similar alcohol-induced behaviors. A major problem in medical research today is that it is difficult to extrapolate from any single model system to humans. Strong evolutionary conservation of a mechanistic response between distantly related organisms, such as flies and mammals, is a powerful predictor that conservation will continue all the way to humans. This review describes the state of the Drosophila alcohol research field. It describes common alcohol behavioral assays, the independent origins of resistance and tolerance, the results of classical genetic screens and candidate gene analysis, and the outcomes of recent genomics studies employing GWAS, transcriptome, miRNA, and genome-wide histone acetylation surveys.

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“…In addition, transcript profiles of isogenic Canton-S flies also identified differentially expressed genes following repeated alcohol exposures (Morozova et al 2006). Acute exposure to concentrated ethanol vapor resulted in rapid down-regulation of genes affecting olfaction and up-regulation of genes encoding biotransformation enzymes.…”

Section: Physiological Effects Of Alcoholmentioning

confidence: 99%

Genetics and genomics of alcohol sensitivity

2014

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Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both genetic and environmental factors contribute to variation in the inebriating effects of alcohol and alcohol addiction among individuals within and across populations. From a genetics perspective, alcohol sensitivity is a quantitative trait determined by the cumulative effects of multiple segregating genes and their interactions with the environment. This review summarizes insights from model organisms as well as human populations that represent our current understanding of the genetic and genomic underpinnings that govern alcohol metabolism and the sedative and addictive effects of alcohol on the nervous system.Electronic supplementary materialThe online version of this article (doi:10.1007/s00438-013-0808-y) contains supplementary material, which is available to authorized users.

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Transcriptional response to alcohol exposure in Drosophila melanogaster

Cited by 92 publications

References 36 publications

Drug-sensitive reward in crayfish: An invertebrate model system for the study of SEEKING, reward, addiction, and withdrawal

Drug-sensitive reward in crayfish: An invertebrate model system for the study of SEEKING, reward, addiction, and withdrawal

Genetics and genomics of alcohol responses in Drosophila

Genetics and genomics of alcohol sensitivity

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