Transcriptional responses in the brain, liver and gonad of Japanese ricefish (Oryzias latipes) exposed to two anti-estrogens

Sun, Liwei; Shao, Xiaolu; Chi, Jian; Hu, Xinhua; Jin, Yuanxiang; Fu, Zhengwei

doi:10.1016/j.cbpc.2011.01.003

Cited by 16 publications

(16 citation statements)

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“…The esr1 and cyp19a1b were closely related to endocrine activities (Kazeto et al, 2004;Kishida et al, 2001;Pikulkaew et al, 2010), and their upregulation usually means estrogen effect. These results contradict earlier reports (Kitano et al, 2007;Sun et al, 2011;Van der Ven et al, 2007). It is possibly because the exposure period in this study was different, and tamoxifen has complex tissuespecific and gender-specific effects on teleost fish.…”

Section: Discussioncontrasting

confidence: 99%

“…There are already reports about the effect of tamoxifen on teleost fish. When exposing adult Japanese rice fish to tamoxifen for 72 h, Sun et al (2011) reported a concentration-dependent increase in male brain esr expression, upregulation of brain ar but downregulation of brain cyp19a1b expression in both sexes, and increased P450arom in male gonads. Van der Ven et al (2007) reported that the exposure of adult zebrafish to high concentrations of tamoxifen caused a decreased concentration of vitellogenin in plasma and liver.…”

Section: Introductionmentioning

confidence: 97%

“…When exposing adult Japanese rice fish to tamoxifen for 72 h, Sun et al . () reported a concentration‐dependent increase in male brain esr expression, upregulation of brain ar but downregulation of brain cyp19a1b expression in both sexes, and increased P450arom in male gonads. Van der Ven et al .…”

Section: Introductionmentioning

confidence: 99%

“…Kitano et al (2007) reported that tamoxifen exposure from 30 to 100 days after hatching strongly suppressed ovary-type P450arom expression in juvenile Japanese flounder. These studies indicated that although tamoxifen showed some complex SERM behavior, they mainly acted as an estrogen antagonist (Hulak et al, 2010;Kitano et al, 2007;Sun et al, 2007Sun et al, , 2011Van der Ven et al, 2007). Yet most of these studies focused on adult fish and gonad, still little is known about the effect of tamoxifen on embryo without mature gonads, and there seems to be some controversial results between different species.…”

Section: Introductionmentioning

confidence: 99%

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Transcriptional and morphological effects of tamoxifen on the early development of zebrafish (Danio rerio)

Liang

Zheng

Zhou

2015

J of Applied Toxicology

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Tamoxifen is a widely used anticancer drug with both an estrogen agonist and antagonist effect. This study focused on its endocrine disrupting effect, and overall environmental significance. Zebrafish embryos were exposed to different concentrations (0.5, 5, 50 and 500 µg l(-1) ) of tamoxifen for 96 h. The results showed a complex effect of tamoxifen on zebrafish embryo development. For the 500 µg l(-1) exposure group, the heart rate was decreased by 20% and mild defects in caudal fin and skin were observed. Expressions of a series of genes related to endocrine and morphological changes were subsequently tested through quantitative real-time polymerase chain reaction. Bisphenol A as a known estrogen was also tested as an endocrine-related comparison. Among the expression of endocrine-related genes, esr1, ar, cyp19a1b, hsd3b1 and ugt1a1 were all increased by tamoxifen exposure, similar to bisphenol A. The cyp19a1b is a key gene that controls estrogen synthesis. Exposure to 0.5, 5, 50 and 500 µg l(-1) of tamoxifen caused upregulation of cyp19a1b expression to 152%, 568%, 953% and 2024% compared to controls, higher than the effects from the same concentrations of bisphenol A treatment, yet vtg1 was suppressed by 24% from exposure to 500 µg l(-1) tamoxifen. The expression of metabolic-related genes such as cyp1a, cyp1c2, cyp3a65, gpx1a, gstp1, gsr and genes related to observed morphological changes such as krt17 were also found to be upregulated by high concentrations of tamoxifen. These findings indicated the potential environmental effect of tamoxifen on teleost early development. Copyright © 2015 John Wiley & Sons, Ltd.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transcriptional and morphological effects of tamoxifen on the early development of zebrafish (Danio rerio)

Liang

Zheng

Zhou

2015

J of Applied Toxicology

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“…As the aquatic environment represents the ultimate sink for most anthropogenic contaminants, fish are directly exposed to a wide variety of EDCs that include natural and synthetic hormones as well as a variety of industrial and agricultural compounds (Sun et al, 2011). Steroidal hormones originating from the excrements of human and animals enter the aquatic environment in their active forms (Lange et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Regulation of reproduction- and biomarker-related gene expression by sex steroids in the livers and ovaries of adult female western mosquitofish (Gambusia affinis)

Huang

Ying

Liu

et al. 2012

Comparative Biochemistry and Physiology Part A: Molecular &

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Antineoplastic Agents: Environmental Prevalence and Adverse Outcomes in Aquatic Organisms

Wormington

María

Kurita

et al. 2020

Enviro Toxic and Chemistry

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Cancer is the second leading cause of death worldwide, with 9.6 million cancer‐related deaths in 2018. Cancer incidence has increased over time, and so has the prescription rate of chemotherapeutic drugs. These pharmaceuticals, known as antineoplastic agents, enter the aquatic environment via human excretion and wastewater. The objectives of the present critical review were to investigate the risk of antineoplastics to aquatic species and to summarize the current state of knowledge regarding their levels in the environment, because many antineoplastics are not adequately removed during wastewater treatment. We conducted 2 separate literature reviews to synthesize data on the global environmental prevalence and toxicity of antineoplastics. The antineoplastics most frequently detected in the environment included cyclophosphamide, ifosfamide, tamoxifen, methotrexate, and 5‐fluorouracil; all were detectable in multiple water sources, including effluent and surface waters. These antineoplastics span 3 different mechanistic classes, with cyclophosphamide and ifosfamide classified as alkylating agents, tamoxifen as a hormonal agent, and methotrexate and 5‐fluorouracil as antimetabolites. Studies that characterize the risk of antineoplastics released into aquatic environments are scarce. We summarize the biological impacts of the most environmentally prevalent antineoplastics on aquatic organisms and propose an adverse outcome pathway for cyclophosphamide and ifosfamide, 2 widely prescribed drugs with a similar immunotoxic mode of action. Acute and chronic ecotoxicity studies using aquatic models are needed for risk characterization of antineoplastics. Environ Toxicol Chem 2020;39:967–985. © 2020 SETAC

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Transcriptional responses in the brain, liver and gonad of Japanese ricefish (Oryzias latipes) exposed to two anti-estrogens

Cited by 16 publications

References 50 publications

Transcriptional and morphological effects of tamoxifen on the early development of zebrafish (Danio rerio)

Transcriptional and morphological effects of tamoxifen on the early development of zebrafish (Danio rerio)

Regulation of reproduction- and biomarker-related gene expression by sex steroids in the livers and ovaries of adult female western mosquitofish (Gambusia affinis)

Antineoplastic Agents: Environmental Prevalence and Adverse Outcomes in Aquatic Organisms

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