Transcriptionally Active Human Papillomavirus Is Strongly Associated With Barrett's Dysplasia and Esophageal Adenocarcinoma

Rajendra, Shanmugarajah; Wang, Bin; Snow, Elizabeth T.; Sharma, Prateek; Pavey, Darren; Merrett, Neil D.; Ball, Madeleine J.; Brain, Terry; Fernando, Ruchira; Robertson, Iain

doi:10.1038/ajg.2013.94

Cited by 62 publications

(75 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among 77 patients with Barrett's esophagus, 17% had detectable HPV at the squamocolumnar junction whereas only 7% had detectable HPV within the columnar segment itself (P ¼ .06). 15 A similar finding was present among the 35 patients with dysplastic Barrett's esophagus, in whom 60% had detectable HPV at the squamocolumnar junction but fewer (40%) had detectable HPV within the more proximal parts of the columnar segment itself (P ¼ .04). Thus, studies sampling only columnar tissue may have very different results than those sampling other parts of the esophagus, although the significance of this with regard to the role of HPV in the pathogenesis of Barrett's esophagus is unknown.…”

Section: The Context Of Prior Researchsupporting

confidence: 72%

“…This study extended the same group's recently published work that showed that among 261 patients with Barrett's esophagus, 81 had detectable HPV DNA. 15 The investigators are appropriately cautious in recommending further studies to evaluate whether either HPV or p53, independently or jointly, might serve as risk markers for more refractory/aggressive disease in clinical trials.…”

Section: The Context Of Prior Researchmentioning

confidence: 99%

See 1 more Smart Citation

Does Human Papillomavirus Cause Esophageal Adenocarcinoma?

Corley

Silverberg

2015

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

Section: The Context Of Prior Researchsupporting

confidence: 72%

Section: The Context Of Prior Researchmentioning

confidence: 99%

Does Human Papillomavirus Cause Esophageal Adenocarcinoma?

Corley

Silverberg

2015

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

“…HPV infection is believed to be responsible for the dramatic rise in head and neck cancers in western countries, which leads to a suspicion that HPV may also play a role in EAC. However, very few investigations of an association between HPV and EAC have been reported, and no evidence of association was found according to these reports [42] . Recently, Rajendra and colleagues [42,43] reported for the first time that transcriptionally active hrHPV was strongly associated with EAC.…”

Section: Hpv and Eacmentioning

confidence: 94%

“…However, very few investigations of an association between HPV and EAC have been reported, and no evidence of association was found according to these reports [42] . Recently, Rajendra and colleagues [42,43] reported for the first time that transcriptionally active hrHPV was strongly associated with EAC. They also showed that increasing viral load and active virus transcription were significantly associated with disease severity in the Barrett's metaplasiadysplasia-adenocarcinoma pathway.…”

Section: Hpv and Eacmentioning

confidence: 94%

Viruses, Other Pathogenic Microorganisms and Esophageal Cancer

Liu

Bao

et al. 2015

Gastrointest Tumors

View full text Add to dashboard Cite

Background: Esophageal cancer (EC) is the eighth most prevalent malignant tumor and the sixth leading cause of cancer mortality throughout the world. Despite the technical developments in diagnosis and treatment, the 5-year survival rate is still low. The etiology of EC remains poorly understood; multiple risk factors may be involved and account for the great variation in EC incidence in different geographic regions. Summary: Infection with carcinogenetic pathogens has been proposed as a risk factor for EC. This review explores the recent studies on the association of human papillomavirus (HPV), Epstein-Barr virus (EBV), Helicobacter pylori and esophageal bacterial biota with EC. Key Message: Among the above-mentioned pathogens, HPV most likely contributes to esophageal squamous cell carcinoma (ESCC) in high-risk populations. New techniques are being applied to studies on the role of infection in EC, which will inevitably bring novel ideas to the field in the near future. Practical Implications: Multiple meta-analyses support the finding of a higher HPV detection rate in regions associated with high risk for ESCC compared to low-risk areas. A potential role of HPV in the rise of esophageal adenocarcinoma (EAC) was proposed recently. However, further studies are required before a firm conclusion can be drawn. Less work has been done in studying the association between EBV and ESCC, and the results are quite controversial. H. pylori infection is found to be inversely related to EC, which is probably due to the reduced incidence of gastroesophageal reflux disease. Analysis of the esophageal bacterial biota revealed distinct clusters of bacteria in normal and diseased esophagi. A type II microbiome rich in Gram-negative bacteria potentially contributes to EAC by inducing chronic inflammation. Novel findings from such studies as these may benefit public health by justifying anti-infection measures to prevent EC.

show abstract

“…A prospective study determined the prevalence of biologically active HPV in esophageal epithelium of patients in BE patients with and without dysplasia and EAC. HPV DNA was estimated by nested PCR and viral transcriptional activity by E6/7 oncogene mRNA expression and p16INK4A immunohistochemistry in fresh frozen and paraffin-embedded esophageal biopsies in patients with BE, BE-related dysplasia, EAC, and controls [53]. Compared to controls, HPV positivity was more common in BE-related dysplasia (68.6 % vs. 18 %, incidence rate ratio 2.94, 95 % CI 1.78 -4.85, pG0.001) and EAC (66.7 % vs. 18 %, incidence rate ratio 2.87, 95 %CI 1.69 -4.86, pG0.001), but not more common in BE patients.…”

Section: Human Papilloma Virusmentioning

confidence: 99%

Diagnostic and Management Implications of Basic Science Advances in Barrett’s Esophagus

Jankowski

Wani

2015

Curr Treat Options Gastro

View full text Add to dashboard Cite

Barrett's esophagus (BE) is a well-established premalignant condition for esophageal adenocarcinoma (EAC), a cancer that has increased in the Western world by nearly sixfold over the past three decades and is associated with a dismal 5-year survival rate (<20 %) especially when detected at a symptomatic state. Given the dramatic rise in EAC incidence and poor outcomes, much attention has focused on screening and surveillance in BE with a goal of identifying curable lesions and improving outcomes in patients with EAC. The limitations of current screening and surveillance strategies provide the necessary impetus to improve diagnostic accuracy and risk stratification of patients with BE. Biomarkers have the potential to predict risk of progression to cancer, identify patients most likely to respond to endoscopic eradication therapies, and ultimately influence patient management and outcomes. The goal of identifying such a biomarker or panel of biomarkers ready for clinical application remains elusive. This review highlights the recent advances in the field of biomarkers. It is increasingly being recognized that a single biomarker is suboptimal in accurate clinical risk stratification of individuals at highest risk for progression to cancer and an ideal risk stratification tool should include a panel of biomarkers in conjunction with clinical and endoscopic factors. Finally, we review advances in our screening strategies with use of Cytosponge, transnasal endoscopy, and tethered capsule endomicroscopy and surveillance strategies with use of advanced imaging techniques. Feasibility of these novel technologies for large population screening and surveillance needs to be assessed in future trials.

show abstract

Transcriptionally Active Human Papillomavirus Is Strongly Associated With Barrett's Dysplasia and Esophageal Adenocarcinoma

Cited by 62 publications

References 46 publications

Does Human Papillomavirus Cause Esophageal Adenocarcinoma?

Does Human Papillomavirus Cause Esophageal Adenocarcinoma?

Viruses, Other Pathogenic Microorganisms and Esophageal Cancer

Diagnostic and Management Implications of Basic Science Advances in Barrett’s Esophagus

Contact Info

Product

Resources

About