2017
DOI: 10.1093/gigascience/gix057
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Transcriptome analysis of the response of Burmese python to digestion

Abstract: Exceptional and extreme feeding behaviour makes the Burmese python (Python bivittatus) an interesting model to study physiological remodelling and metabolic adaptation in response to refeeding after prolonged starvation. In this study, we used transcriptome sequencing of 5 visceral organs during fasting as well as 24 hours and 48 hours after ingestion of a large meal to unravel the postprandial changes in Burmese pythons. We first used the pooled data to perform a de novo assembly of the transcriptome and supp… Show more

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Cited by 20 publications
(14 citation statements)
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References 71 publications
(101 reference statements)
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“…Future work on additional varanid species, and other squamate outgroups, will test these hypotheses. Selective pressures acting on these mitochondrial genes in Komodo dragons is consistent with the increased expression of genes associated with oxidative capacity found in pythons after feeding 97 , 98 .…”
Section: Discussionsupporting
confidence: 73%
“…Future work on additional varanid species, and other squamate outgroups, will test these hypotheses. Selective pressures acting on these mitochondrial genes in Komodo dragons is consistent with the increased expression of genes associated with oxidative capacity found in pythons after feeding 97 , 98 .…”
Section: Discussionsupporting
confidence: 73%
“…It is possible that brain cell proliferation may not increase at this point because most of the python's energy is focused toward the immediate need: the energetically expensive process of digesting and absorbing a large meal, in which both body reserves and nutrients from the ingested meal are used to 'pay' for the metabolic costs of feeding (Secor and Diamond, 1995;Starck et al, 2004). Visceral organs of pythons respond to feeding by upregulating many genes related to metabolic processes, cell growth and proliferation, and protective responses to oxidative stress (Andrew et al, 2015(Andrew et al, , 2017Duan et al, 2017), in keeping with the fact that proliferation of cells in these organs occurs during the SDA window. Proliferative activity in the brain does occur during this time period, but it is not extensive until 6 days after feeding.…”
Section: Results and Discussion Treatment Effects On New Cell Densitymentioning
confidence: 99%
“…Our transcriptome of the vertebrata core genes was more complete than any previously sequenced transcriptome of other snakes [ 54 ]. However, it is expected that not all genes are expressed in the venom gland.…”
Section: Discussionmentioning
confidence: 99%
“…The purified stonefish toxins commonly present potent hemolytic activities due to its ability to form pores in the cell membrane. Also, these toxins elicit potent hypotension, inhibit neuromuscular function, and induce cardiovascular collapse in humans and native predators [ 54 , 68 ]. The stonustoxin-like were also found in the transcriptome of the venom gland of annelids [ 69 ] and are found in a variety of vertebrates, including the common ostrich, platypus, tasmanian devil, and coelacanth [ 70 ].…”
Section: Discussionmentioning
confidence: 99%