Transcriptome analysis reveals that hydrogen sulfide exposure suppresses cell proliferation and induces apoptosis through ciR-PTPN23/miR-15a/E2F3 signaling in broiler thymus

Hu, Xueyuan; Chi, Qianru; Liu, Zhaoyi; Tao, Dayong; Wang, Yu; Cong, Yingzi; Li, Shu

doi:10.1016/j.envpol.2021.117466

Cited by 9 publications

(3 citation statements)

References 62 publications

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“…Impairment of immune function by H 2 S was also observed in the spleen, which caused inflammatory reactions and initiated cell apoptosis ( Zheng et al, 2019 ). Similar changes were found in bursa fabricii at 20 ppm H 2 S ( Hu et al, 2018 ) and the thymus ( Xueyuan et al, 2021 ; Wang et al, 2022 ). Considering the muscular system, the action of the above factor contributes to the breakdown of heart muscle cells due to mitochondrial fission ( Wang et al, 2019 ).…”

Section: Immunosafety and Immune Securitysupporting

confidence: 78%

Modulation of the immune system of chickens a key factor in maintaining poultry production—a review

et al. 2023

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Section: Immunosafety and Immune Securitysupporting

confidence: 78%

Modulation of the immune system of chickens a key factor in maintaining poultry production—a review

et al. 2023

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“…Transcriptome sequencing ( RNA-Seq ) has been utilized to investigate the reproductive and developmental mechanisms in poultry. Numerous genes associated with gonadal development have been identified through screenings conducted by Bello et al (2021) , Hu et al (2021) , and Zhang et al (2023) . MiRNAs are small molecule RNAs that do not encode genes but can regulate gene transcription or post-transcriptional processes.…”

Section: Introductionmentioning

confidence: 99%

Analysis of circRNA-miRNA-mRNA regulatory network of embryonic gonadal development in Mulard duck

Li,

Xin,

Zhang

et al. 2024

Poultry Science

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“…Circular RNAs (circRNAs) are a kind of closed single-stranded circular RNAs without coding potential. CircRNAs exert crucial regulation in multiple physiological and pathophysiological processes [ 7 ]. More importantly, the dysregulation of circRNAs has been shown to be implicated in chemoresistance.…”

Section: Introductionmentioning

confidence: 99%

Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer

et al. 2023

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Platinum-based chemotherapy is one of the predominant strategies for treating ovarian cancer (OC), however, platinum resistance greatly influences the therapeutic effect. Circular RNAs (circRNAs) have been found to participate in the pathogenesis of platinum resistance. Our aim was to explore the involvement of circ_0078607 in OC cell cisplatin (DDP) resistance and its potential mechanisms. Circ_0078607, miR-196b-5p, and growth arrest-specific 7 (GAS7) levels were assessed by qPCR. Circ_0078607 stability was assessed by ribonuclease R digestion and actinomycin D treatment. Cell viability of various conic of DDP treatment was measured by CCK-8. The cell proliferation was determined by CCK-8 and colony formation assay. Western blotting was performed for determining GAS7, ABCB1, CyclinD1 and Bcl-2 protein levels. The direct binding between miR-196b-5p and circ_0078607 or GAS7 was validated by dual-luciferase reporter and RIP assay. DDP resistance in vivo was evaluated in nude mice. Immunohistochemistry staining for detecting Ki67 expression in xenograft tumours. Circ_0078607 and GAS7 was down-regulated, but miR-196b-5p was up-regulated in OC samples and DDP-resistant cells. Overexpression of circ_0078607 inhibited DDP resistance, cell growth and induced apoptosis in DDP-resistant OC cells. Mechanistically, circ_0078607 sequestered miR-196b-5p to up-regulate GAS7. MiR-196b-5p mimics reversed circ_0078607 or GAS7 overexpression-mediated enhanced sensitivity. Finally, circ_0078607 improved the sensitivity of DDP in vivo . Circ_0078607 attenuates DDP resistance via miR-196b-5p/GAS7 axis, which highlights the therapeutic potential of circ_0078607 to counter DDP resistance in OC.

show abstract

Transcriptome analysis reveals that hydrogen sulfide exposure suppresses cell proliferation and induces apoptosis through ciR-PTPN23/miR-15a/E2F3 signaling in broiler thymus

Cited by 9 publications

References 62 publications

Modulation of the immune system of chickens a key factor in maintaining poultry production—a review

Modulation of the immune system of chickens a key factor in maintaining poultry production—a review

Analysis of circRNA-miRNA-mRNA regulatory network of embryonic gonadal development in Mulard duck

Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer

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