Transcriptome profiling analysis of Mactra veneriformis by deep sequencing after exposure to 2,2′,4,4′-tetrabromodiphenyl ether

Shi, Pengju; Dong, S. S.; Zhang, Huanjun; Niu, Zhuang; Fang, Yan

doi:10.1007/s00343-018-6347-y

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…Particularly, these analyses have provided information to analyse complex relations among disease, drugs, and organisms [22]. Moreover, RNA-seq has been used in marine bivalves to understand physiological stress [23,24], toxicological effects [25,26], and resistance to disease and immunology [27,28]. In this sense, the RNA-seq analysis helps to understand the molecular response activated by the effect of time-dependent diluted immunomodulatory treatments, which allowed identifying the down-and up-regulated genes of juvenile scallops in response to HDIC.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analysis of Catarina scallop (Argopecten ventricosus) juveniles treated with highly-diluted immunomodulatory compounds reveals activation of non-self-recognition system

et al. 2020

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Marine bivalve hatchery productivity is continuously challenged by apparition and propagation of new diseases, mainly those related to vibriosis. Disinfectants and antibiotics are frequently overused to prevent pathogen presence, generating a potential negative impact on the environment. Recently, the use of highly diluted compounds with immunostimulant properties in marine organisms has been trailed successfully to activate the self-protection mechanisms of marine bivalves. Despite their potential as immunostimulants, little is known about their way of action. To understand their effect, a comparative transcriptomic analysis was performed with Argopecten ventricosus juveniles. The experimental design consisted of four treatments formulated from pathogenic Vibrio lysates at two dilutions: [(T1) Vibrio parahaemolyticus and Vibrio alginolyticus 1D; (T2) V. parahaemolyticus and V. alginolyticus 7C]; minerals [(T3) PhA+SiT 7C], scorpion venom [(T4) ViT 31C]; and one control (C1) hydro-alcoholic solution (ethanol 1%). The RNA sequencing (RNAseq) analysis showed a higher modulation of differentially expressed genes (DEG) in mantle tissue compared to gill tissue. The scallops that showed a higher number of DEG related to immune response in mantle tissue corresponded to T1 (V. parahaemolyticus and V. alginolyticus lysate) and T3 (Silicea terra®-Phosphoric acid®). The transcriptome analysis allowed understanding some interactions between A. ventricosus juveniles and highly-diluted treatments.

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Section: Introductionmentioning

confidence: 99%

Transcriptome analysis of Catarina scallop (Argopecten ventricosus) juveniles treated with highly-diluted immunomodulatory compounds reveals activation of non-self-recognition system

et al. 2020

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“…Mactra veneriformis is an infaunal suspension-feeding bivalve, widely distributed in the coastal areas of China, Japan, and South Korea, and is of economic importance in China. The clam can efficiently accumulate pollutants, and has evolved to respond to pollutants rapidly (Wang et al, 2005;Fang et al, 2010;Shi et al, 2018), making it a good candidate of experimental organism in toxicology research.…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of decabromodiphenyl ether affects the antioxidant system in the clam Mactra veneriformis

Zhu

Yang

et al. 2019

Environmental Toxicology and Pharmacology

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Antioxidant enzymes play vital roles against oxidative stress induced by decabromodiphenyl ether (BDE-209), being widespread in marine environment. However, the effect of BDE-209 on antioxidant enzymes remains poorly understood in marine bivalves. In this study, the clams Mactra veneriformis were exposed to 0.1, 1, and 10 μg/L BDE-209 for 7 days and then maintained in clean seawater for 3 days as the depuration. The bioaccumulation of BDE-209 and the effects on superoxide dismutase, catalase, and glutathione peroxidase were investigated. BDE-209 accumulation was concentration-dependent and decreased by 36%-52% after recovery. Malondialdehyde contents increased in a time-and dose-dependent manner. mRNA expression and activity of antioxidant enzymes changed with different patterns and recovered after depuration. These results suggested that antioxidant systems were triggered to protect the clams from oxidative damage caused by BDE-209. Thus, this research is helpful in elucidating the effect of BDE-209 on antioxidant system in marine bivalves.

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Toxicological impacts of bromide flame retardants on marine bivalves

Deng,

Chen,

Zhong

et al. 2024

Marine Bivalve Mollusks and Emerging Pollutants

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Transcriptome profiling analysis of Mactra veneriformis by deep sequencing after exposure to 2,2′,4,4′-tetrabromodiphenyl ether

Cited by 6 publications

References 38 publications

Transcriptome analysis of Catarina scallop (Argopecten ventricosus) juveniles treated with highly-diluted immunomodulatory compounds reveals activation of non-self-recognition system

Transcriptome analysis of Catarina scallop (Argopecten ventricosus) juveniles treated with highly-diluted immunomodulatory compounds reveals activation of non-self-recognition system

Bioaccumulation of decabromodiphenyl ether affects the antioxidant system in the clam Mactra veneriformis

Toxicological impacts of bromide flame retardants on marine bivalves

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