Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection

Meijer, Annemarie H.; Verbeek, Fons J.; Salas‐Vidal, Enrique; Corredor-Adámez, Maximiliano; Bussman, Jeroen; Sar, Astrid M. van der; Otto, G.; Geisler, Robert; Spaink, Herman P.

doi:10.1016/j.molimm.2004.11.014

Cited by 130 publications

(85 citation statements)

References 53 publications

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“…These studies show a modest but complex host response in the early stages of infection (Meijer et al 2005;Hegedus et al 2009). Detailed analysis of immune factors involved in mycobacterial disease depends on the generation of more knockout zebrafish and development of specific antibodies directed against immune cells and chemokines/cytokines.…”

Section: Animal Models Of Tuberculosis: Zebrafishmentioning

confidence: 96%

“…Cite this article as Cold Spring Harb Perspect Med 2015;5:a018580 www.perspectivesinmedicine.org quencing studies (Meijer et al 2005;Hegedus et al 2009;Meijer and Spaink 2011;van der Vaart et al 2012). These studies show a modest but complex host response in the early stages of infection (Meijer et al 2005;Hegedus et al 2009).…”

Section: Animal Models Of Tuberculosis: Zebrafishmentioning

confidence: 99%

See 1 more Smart Citation

Animal Models of Tuberculosis: Zebrafish

Leeuwen

Sar

Bitter

2014

Cold Spring Harbor Perspectives in Medicine

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Correspondence: a.vandersar@vumc.nl Over the past decade the zebrafish (Danio rerio) has become an attractive new vertebrate model organism for studying mycobacterial pathogenesis. The combination of mediumthroughput screening and real-time in vivo visualization has allowed new ways to dissect host pathogenic interaction in a vertebrate host. Furthermore, genetic screens on the host and bacterial sides have elucidated new mechanisms involved in the initiation of granuloma formation and the importance of a balanced immune response for control of mycobacterial pathogens. This article will highlight the unique features of the zebrafish-Mycobacterium marinum infection model and its added value for tuberculosis research.

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Section: Animal Models Of Tuberculosis: Zebrafishmentioning

confidence: 96%

Section: Animal Models Of Tuberculosis: Zebrafishmentioning

confidence: 99%

Animal Models of Tuberculosis: Zebrafish

Leeuwen

Sar

Bitter

2014

Cold Spring Harbor Perspectives in Medicine

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“…Microarray studies show that GRN is expressed in CD34 ϩ bone marrow cells (20) and is upregulated in acute myeloid leukemia blasts vs. normal progenitor CD34 ϩ cells (62). Moreover, in the periphery, it is expressed during chemokine-stimulated alveolar trafficking of monocytes (52), in inflammatory arthritis but not osteoarthritis (27), during injury to the spinal cord and brain (37,38), and in a zebrafish model of chronic tuberculosis (39).…”

mentioning

confidence: 99%

Regulation of progranulin expression in myeloid cells

Ong

He²,

Kriazhev³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Progranulin (pgrn; granulin-epithelin precursor, PC-cell-derived growth factor, or acrogranin) is a multifunctional secreted glycoprotein implicated in tumorigenesis, development, inflammation, and repair. It is highly expressed in macrophage and monocyte-derived dendritic cells. Here we investigate its regulation in myeloid cells. All-trans retinoic acid (ATRA) increased pgrn mRNA levels in myelomonocytic cells (CD34 ϩ progenitors; monoblastic U-937; monocytic THP-1; progranulocytic HL-60; macrophage RAW 264.7) but not in nonmyeloid cells tested. Interleukin-4 impaired basal expression of pgrn in U-937. Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation. The response of pgrn mRNA to ATRA differs in U-937 and HL-60 lineages. In U-937, ATRA and chemical differentiation agents greatly increased pgrn mRNA stability, whereas, in HL-60, ATRA accelerated pgrn mRNA turnover. The initial upregulation of pgrn mRNA after stimulation with ATRA was independent of de novo protein synthesis in U-937 but not HL-60. Chemical blockade of nuclear factor-B (NF-B) activation impaired ATRAstimulated pgrn expression in HL-60 but not U-937, whereas in U-937 it blocked PMA-induced pgrn mRNA expression, suggestive of cellspecific roles for NF-B in determining pgrn mRNA levels. We propose that: 1) ATRA regulates pgrn mRNA levels in myelomonocytic cells; 2) ATRA acts in a cell-specific manner involving the differential control of mRNA stability and differential requirement for NF-B signaling; and 3) elevated pgrn mRNA expression is characteristic of more mature cells and does not stimulate differentiation.granulin; stem cell factor; colony-stimulating factor THE GRANULIN-EPITHELIN precursor progranulin (pgrn; see Ref. 4), which is also called proepithelin (47), PC-cell-derived growth factor (66), or acrogranin (1), is a multifunctional regulatory protein that promotes mitosis, survival, and migration in many cell types (43). It stimulates growth factor-related signaling pathways such as the phosphorylation of shc, p44/42 mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B/AKT, and the p70 S6 kinase (24,35,65) and contributes to carcinogenesis in breast (51), ovarian (16,26), renal (18), hepatocellular (10), and prostate (44) cancers, gliomas (33), and multiple myelomas (63). Physiologically, pgrn is involved in wound repair (25,67) and is expressed during development (8) where it regulates cavitation in preimplantation embryos (17), blastocyst hatching (48), and malespecific differentiation of the neonatal hypothalamus (56,58).The granulin (GRN) gene is highly expressed in monocytederived cells, being the 17th and 30th most abundant transcript in human macrophage (9) and monocyte-derived dendritic cells (21), respectively. Peptides derived from pgrn, the granulin/ epit...

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“…29 Infection with this species has been documented to alter gene expression in several studies. [30][31][32][33] Finally, fast-growing M. chelonae has been observed to autofluoresce, which may confound studies using fluorescence to examine biological processes. 34 M. abscessus is very close phylogenetically to M. chelonae, and similarly produces predominantly subclinical infections; the recently described M. saopaulense also belongs to this group.…”

Section: Choice Of Agentsmentioning

confidence: 99%

Recommendations for Health Monitoring and Reporting for Zebrafish Research Facilities

2016

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The presence of subclinical infection or clinical disease in laboratory zebrafish may have a significant impact on research results, animal health and welfare, and transfer of animals between institutions. As use of zebrafish as a model of disease increases, a harmonized method for monitoring and reporting the health status of animals will facilitate the transfer of animals, allow institutions to exclude diseases that may negatively impact their research programs, and improve animal health and welfare. All zebrafish facilities should implement a health monitoring program. In this study, we review important aspects of a health monitoring program, including choice of agents, samples for testing, available testing methodologies, housing and husbandry, cost, test subjects, and a harmonized method for reporting results. Facilities may use these recommendations to implement their own health monitoring program.

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Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection

Cited by 130 publications

References 53 publications

Animal Models of Tuberculosis: Zebrafish

Animal Models of Tuberculosis: Zebrafish

Regulation of progranulin expression in myeloid cells

Recommendations for Health Monitoring and Reporting for Zebrafish Research Facilities

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