Transcriptomes from German shepherd dogs reveal differences in immune activity between atopic dermatitis affected and control skin

Tengvall, Katarina; Bergvall, Kerstin; Olsson, Mia; Ardesjö-Lundgren, Brita; Farias, Fabiana; Kierczak, Marcin; Hedhammar, Åke; Lindblad‐Toh, Kerstin; Andersson, Gerhard

doi:10.1007/s00251-020-01169-3

Cited by 10 publications

(11 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another research showed that this gene was upregulated in Duroc pigs with high contents of intramuscular fat and saturated and monounsaturated fatty acids in the gluteus medium muscle (Cardoso et al, 2018). Increased expression of the CD209 gene has also been observed in skin biopsies from German shepherd dogs with atopic dermatitis and a relationship between this CD209 protein and inflammation has been suggested (Tengvall et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Understanding the role of myoglobin content in Iberian pigs fattened in an extensive system through analysis of the transcriptome profile

et al. 2022

View full text Add to dashboard Cite

Meat color is considered one of the most important meat quality traits and the first attribute that is sensorially perceived, influencing the purchase decision of consumers (Mancini & Hunt, 2005). A bright cherryred color is normally used as a healthy indicator in fresh meat, while PSE (pale, soft, exudative) or DFD (dark, firm, dry) meats do not satisfy the consumer preferences (Yu et al., 2017).

show abstract

Section: Discussionmentioning

confidence: 99%

Understanding the role of myoglobin content in Iberian pigs fattened in an extensive system through analysis of the transcriptome profile

et al. 2022

View full text Add to dashboard Cite

show abstract

“…15 However, a follow-up study published after the previous review disputed the relevance of these findings because no differences in the expression of PKP2 were observed between dogs with AD (with the risk alleles) and clinically healthy control dogs (without the risk alleles). 16 Since the last ICADA canine pathogenesis review in 2015, only two GWAS have been identified. In a cohort of WHWTs (97 atopic and 89 control dogs) born in the USA, a new 2.7-Mb genomic region on canine chromosome (CFA) 3, which includes 37 genes, was identified.…”

Section: Genome-wide Association Studiesmentioning

confidence: 99%

Update on the role of genetic factors, environmental factors and allergens in canine atopic dermatitis

Hensel,

Saridomichelakis,

Eisenschenk

et al. 2023

Veterinary Dermatology

View full text Add to dashboard Cite

BackgroundCanine atopic dermatitis (cAD) is a common, complex and multifactorial disease involving, among others, genetic predisposition, environmental factors and allergic sensitisation.ObjectiveThis review summarises the current evidence on the role of genetic and environmental factors and allergic sensitisation in the pathogenesis of cAD since the last review by ICADA in 2015.Materials and MethodsOnline citation databases and proceedings from international meetings on genetic factors, environmental factors and allergens relevant to cAD that had been published between 2015 and 2022 were reviewed.ResultsDespite intensive research efforts, the detailed genetic background predisposing to cAD and the effect of a wide range of environmental factors still need more clarification. Genome‐wide association studies and investigations on genetic biomarkers, such as microRNAs, have provided some new information. Environmental factors appear to play a major role. Lifestyle, especially during puppyhood, appears to have an important impact on the developing immune system. Factors such as growing up in a rural environment, large size of family, contact with other animals, and a nonprocessed meat‐based diet may reduce the risk for subsequent development of cAD. It appears that Toxocara canis infection may have a protective effect against Dermatophagoides farinae‐induced cAD. House dust mites (D. farinae and D. pteronyssinus) remain the most common allergen group to which atopic dogs react. Currently, the major allergens related to D. farinae in dogs include Der f 2, Der f 15, Der f 18 and Zen 1.Conclusions and Clinical RelevanceCanine atopic dermatitis remains a complex, genetically heterogeneous disease that is influenced by multiple environmental factors. Further, well‐designed studies are necessary to shed more light on the role of genetics, environmental factors and major allergens in the pathogenesis of cAD.

show abstract

“…Interestingly, the results of these studies revealed multipolar immunological axis upregulation (Th1, Th2, Th17 and Th22) in cAD as is found in humans with AD. [10][11][12][13][14] This indicates that cytokine network activation in AD is, in fact, no longer considered to simply involve a specific group of cytokines (i.e. upregulation of only Th2 cytokines) and is instead the interplay between a large number of cytokines.…”

Section: Updates On Cytokines and Chemokines In Canine Atopic Dermatitismentioning

confidence: 99%

Update on the role of cytokines and chemokines in canine atopic dermatitis

Tamamoto-Mochizuki

Santoro

Saridomichelakis

et al. 2023

Veterinary Dermatology

View full text Add to dashboard Cite

BackgroundCytokines and chemokines play central roles in the pathogenesis of canine atopic dermatitis (cAD). Numerous studies have been published and provide new insights into their roles in cAD.ObjectivesTo summarise the research updates on the role of cytokines and chemokines in the pathogenesis of cAD since the last review by the International Committee on Allergic Diseases of Animals in 2015.Material and MethodsOnline citation databases, abstracts and proceedings from international meetings on cytokines and chemokines relevant to cAD that had been published between 2015 and 2022 were reviewed.ResultsAdvances in technologies have allowed the simultaneous analysis of a broader range of cytokines and chemokines, which revealed an upregulation of a multipolar immunological axis (Th1, Th2, Th17 and Th22) in cAD. Most studies focused on specific cytokines, which were proposed as potential novel biomarkers and/or therapeutic targets for cAD, such as interleukin‐31. Most other cytokines and chemokines had inconsistent results, perhaps as a consequence of their varied involvement in the pathogenesis of different endotypes of cAD.Conclusions and Clinical RelevanceInconsistent results for many cytokines and chemokines illustrate the difficulty of studying the complex cytokine and chemokine networks in cAD, and highlight the need for more comprehensive and structured studies in the future.

show abstract

Transcriptomes from German shepherd dogs reveal differences in immune activity between atopic dermatitis affected and control skin

Cited by 10 publications

References 65 publications

Understanding the role of myoglobin content in Iberian pigs fattened in an extensive system through analysis of the transcriptome profile

Understanding the role of myoglobin content in Iberian pigs fattened in an extensive system through analysis of the transcriptome profile

Update on the role of genetic factors, environmental factors and allergens in canine atopic dermatitis

Update on the role of cytokines and chemokines in canine atopic dermatitis

Contact Info

Product

Resources

About