Transcriptomic analysis identifies a unique, intermittent hypoxia mediated inflammatory profile: evidence from a cross-over randomised CPAP withdrawal trial, with and without supplemental oxygen, in OSA

Turnbull, Christopher; Lee, Lennard; Petousi, Nayia; Stradling, John

doi:10.1183/13993003.congress-2018.oa3287

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“…T urnbull et al . [3] explored the effects of IH on leukocyte gene expression from OSA patients undergoing continuous positive airway pressure (CPAP) withdrawal with and without supplemental oxygen. Patients previously treated with CPAP were withdrawn onto 14 nights of supplemental oxygen (5 L·min −1 ) or sham in a crossover randomised controlled trial (RCT).…”

Section: Pathophysiological Aspects Of Sleep Disordered Breathing: Inmentioning

confidence: 99%

“…T urnbull et al . [3] identified several genes that were only upregulated with CPAP withdrawal onto sham, suggesting that gene changes in circulating leukocytes were IH dependent. The authors also showed activation of key inflammatory pathways, suggesting a role for NF-κB-mediated inflammation in IH-mediated cardiovascular disease in OSA.…”

Section: Pathophysiological Aspects Of Sleep Disordered Breathing: Inmentioning

confidence: 99%

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Highlights from the 2018 European Respiratory Society International Congress: sleep and clinical physiology

et al. 2019

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The 2018 European Respiratory Society (ERS) International Congress held in Paris, France, served as a platform to discover the latest research on respiratory diseases, the improvement in their treatments and patient care. Specifically, the scientific sessions organised by ERS Assembly 4 provided novel insights into sleep disordered breathing and fresh knowledge in respiratory physiology, stressing its importance to understanding and treating respiratory diseases. This article, divided by session, will summarise the most relevant studies presented at the ERS International Congress. Each session has been written by early career members specialised in the different fields of this interdisciplinary assembly.

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Section: Pathophysiological Aspects Of Sleep Disordered Breathing: Inmentioning

confidence: 99%

Section: Pathophysiological Aspects Of Sleep Disordered Breathing: Inmentioning

confidence: 99%

Highlights from the 2018 European Respiratory Society International Congress: sleep and clinical physiology

et al. 2019

View full text Add to dashboard Cite

show abstract

Transcriptomic analysis identifies a unique, intermittent hypoxia mediated inflammatory profile: evidence from a cross-over randomised CPAP withdrawal trial, with and without supplemental oxygen, in OSA

Cited by 1 publication

References 0 publications

Highlights from the 2018 European Respiratory Society International Congress: sleep and clinical physiology

Highlights from the 2018 European Respiratory Society International Congress: sleep and clinical physiology

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