Transcriptomic Analysis of MAPK Signaling in NSC-34 Motor Neurons Treated with Vitamin E

Chiricosta, Luigi; Tardiolo, Giuseppe; Bramantı, Placido; Mazzon, Emanuela

doi:10.3390/nu11051081

Cited by 9 publications

(4 citation statements)

References 59 publications

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“…This study also concluded that VitE significantly improved motor functioning in ALS patients [305]. In a study focusing on transcriptional profiles, VitE prevented the death of NSC-34 motor neurons in ALS through the downregulation of the c-Jun N-terminal kinase (JNK) and p38 MAPK pathway (cell death), and upregulation of the extracellular signal-regulated kinase (ERK) pathways (cell survival) [306].…”

Section: Vitamins In Amyotrophic Lateral Sclerosismentioning

confidence: 80%

The Role of Vitamins in Neurodegenerative Disease: An Update

et al. 2021

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Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson’s disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.

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Section: Vitamins In Amyotrophic Lateral Sclerosismentioning

confidence: 80%

The Role of Vitamins in Neurodegenerative Disease: An Update

et al. 2021

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“…α-tocopherol is the main form of vitamin E in tissues and is known to be an effective natural scavenger of reactive oxygen species [31] . A study evaluated the changes induced in the transcriptional pro le of NSC-34 motor neurons treated with α-tocopherol and found that α-tocopherol may be an e cacious therapy in preventing motor neuron death [32] . A previous study also suggested that tocopherol derivatives can reduce muscle atrophy and improve survival in SOD1 G86R mouse models by protecting against oxidative and DNA damage-induced stresses [33] .…”

Section: Discussionmentioning

confidence: 99%

Genetically predict diet-derived Antioxidants and risk of Neurodegenerative diseases among individuals of European descent: a Mendelian randomization study

Duan

et al. 2023

Preprint

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Background The prevalence of neurodegenerative disorders (NDDs) is increasing, and there is no cure for any of these diseases. Antioxidants have been associated with several diseases in observational studies. However, the relationship between antioxidants and neurodegenerative diseases remains unclear. The purpose of this study is to use publicly available genome-wide association studies (GWAS) summary statistics to examine the causal relationship between diet-derived antioxidants and the risk of NDDs. Methods Single-nucleotide polymorphisms associated with diet-derived antioxidants (vitamin A, vitamin B6, vitamin C, vitamin E, carotene, β-carotene, lycopene, zinc, and selenium) and their metabolites (α-tocopherol, γ-tocopherol, ascorbate, and retinol) were employed as instrumental variables. The NDDs we studied included Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), which were obtained from GWASs conducted in the European population. Two-sample Mendelian randomization (MR) was performed together with a series of sensitivity analyses. The main statistical analyses were conducted using package “TwoSampleMR (V.0.5.6)” in R (V.4.2.0) Results Genetically predicted α-tocopherol led to a lower risk of ALS (OR 0.45; 95% CI, 0.31, 0.66; p = 3.97E-05) based on the random-effect IVW method, and no evidence of heterogeneity and horizontal pleiotropy was found. In addition, we found a potential protective effect of vitamin E and ascorbate on PD, carotene on ALS, and retinol on FTD. However, no circulating antioxidants studied affect the risk for AD. Conclusion This study indicated that some diet-derived antioxidants or their metabolites showed evidence of causality in NDDs and provided promising targets for therapeutics.

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“…The antioxidant activities of vitamin E have been linked to pain management therapy and are actively linked to the pain signaling pathway (15,16). Hence, using in-vivo animal models with breast cancer-induced bone pain might postulate the roles of vitamin E supplementation in managing pain caused by cancer.…”

Section: Introductionmentioning

confidence: 99%

Vitamin E Action on Bone Signaling Pathways, Rankl/Rank/Opg in a Rat Model of Breast Cancer-Induced Bone Pain

Baharuddin,

Syifaa Nasir,

Mansor

et al. 2023

JUMMEC

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Cancer-induced bone pain is currently facing inadequate pain management due to unwanted side effects and relative ineffectiveness. The search for alternative therapy to alleviate pain and target a few mechanism pathways might improve survival in metastatic patients. Vitamin E which has been promoted as anti-inflammatory, anti-cancer, and anti-metastatic were chosen in this study to potentiate its capability in a cancer-induced bone pain rat model. Rats were randomly grouped into five groups, and a breast cancer cell line was induced into the left femur of four groups: Negative Control (NC), Alpha Tocopherol (ATF), Tocotrienol Rich Fraction (TRF) and Zoledronic Acid (ZA), whereas Sham group as healthy subjects induced with supplementary media. Pain assessment tests were carried out at four days intervals. The animals were sacrificed after 21 days following SPECT/CT imaging. Bone specimens were analyzed for ELISA and gene expression studies. The results showed that the animal model was successfully validated via the presence of abnormal uptake of the skeletal system. Pain assessment tests demonstrated that vitamin E, specifically TRF significantly alleviate pain compared to the NC group. Biomarker activity illustrated that the TRF supplement group was able to regulate the bone turnover activity comparable to the ZA treatment group. Gene expression studies signify the role of TRF supplement comparable to the ZA group in the ability to regulate osteoclastogenesis, osteoclast activation, and regulating the secretion of metastatic cancer cytokine. This finding addressed the beneficial potency of TRF compared to ATF as a therapeutic option in the management of cancer-induced bone pain.

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Transcriptomic Analysis of MAPK Signaling in NSC-34 Motor Neurons Treated with Vitamin E

Cited by 9 publications

References 59 publications

The Role of Vitamins in Neurodegenerative Disease: An Update

The Role of Vitamins in Neurodegenerative Disease: An Update

Genetically predict diet-derived Antioxidants and risk of Neurodegenerative diseases among individuals of European descent: a Mendelian randomization study

Vitamin E Action on Bone Signaling Pathways, Rankl/Rank/Opg in a Rat Model of Breast Cancer-Induced Bone Pain

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