2022
DOI: 10.1016/j.bbamcr.2022.119326
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Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways

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Cited by 19 publications
(11 citation statements)
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“…The direct interrogation of mRNA and protein changes is a topic that remains to be further investigated as a plethora of mechanisms which are species-specific govern transcription, translation, and protein homeostasis. Reports on human microglial phenotypes and subpopulations that are associated with disease hallmarks, aging or metabolic states have demonstrated that transcription of HKs or PFKs are differentially regulated in association with Aβ responses similarly to inflammatory microglia, while tau responses were comparable to homeostatic microglia 4 , 60 . Some studies have proposed glucose transporters 61 , HK2, and PFKs as therapeutic targets in neurodegenerative diseases with altered microglial functions aiming to attenuate glycolytic fluxes.…”
Section: Discussionmentioning
confidence: 99%
“…The direct interrogation of mRNA and protein changes is a topic that remains to be further investigated as a plethora of mechanisms which are species-specific govern transcription, translation, and protein homeostasis. Reports on human microglial phenotypes and subpopulations that are associated with disease hallmarks, aging or metabolic states have demonstrated that transcription of HKs or PFKs are differentially regulated in association with Aβ responses similarly to inflammatory microglia, while tau responses were comparable to homeostatic microglia 4 , 60 . Some studies have proposed glucose transporters 61 , HK2, and PFKs as therapeutic targets in neurodegenerative diseases with altered microglial functions aiming to attenuate glycolytic fluxes.…”
Section: Discussionmentioning
confidence: 99%
“…Reports of human microglial phenotypes and subpopulations that are associated to disease hallmarks, aging or metabolic state have demonstrated that transcription of HKs or PFKs are differentially regulated in association with amyloid-beta responses – similarly to inflammatory microglia, and tau responses – similarly to homeostatic microglia 4,42 . Some studies have proposed glucose transporters 43 , HK2, and PFKs as therapeutic targets in neurodegenerative diseases with altered microglial functions aiming to attenuate glycolytic fluxes.…”
Section: Discussionmentioning
confidence: 99%
“…Alzheimer’s disease (AD) is the most common cause of dementia, and it is defined by cognitive decline coupled with extracellular deposit of amyloid-β (Aβ) protein in the form of plaques and intracellular hyperphosphorylation of the tau protein in the form of tangles [ 1 ]. The pathogenesis of AD begins with impaired synaptic function, which may result from extracellular deposition of the Aβ in the form of senile plaques, the appearance of intracellular neurofibrillary tangles, and cholinergic deficit.…”
Section: Introductionmentioning
confidence: 99%