Transcriptomic and metabolomic analyses provide insights into the attenuation of neuroinflammation by nervonic acid in MPTP-stimulated PD model mice

Abstract

Nervonic acid is one of the most promising bioactive fatty acids, which is believed to be beneficial for the recovery of human cognitive disorders.

Gastrodia elata polysaccharide alleviates Parkinson's disease via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota

“…Moreover, neuroinflammation is another contributor that causes or aggravates PD. [8][9][10] It has been found that neuronal death in the substantia nigra (SN) and striatum of PD patients is accompanied by significantly activated glial cells, which produce a wide range of inflammatory cytokines, leading to long-term sustained death of DA neurons through inducing apoptosis and other pathways. [11][12][13] Some researchers have even injected LPS into the brains of mice to activate the inflammatory response, resulting in the loss of DA neurons and successfully inducing PD.…”

Acer truncatum Bunge seed oil ameliorated oxaliplatin-induced demyelination by improving mitochondrial dysfunction via the Pink1/Parkin mitophagy pathway

“…9 ATSO has been demonstrated to prevent and ameliorate various neurological diseases such as experimental allergic encephalomyelitis, Parkinson's disease, cognitive impairment, adrenoleukodystrophy and hypoxic-ischemic encephalopathy. [10][11][12][13][14][15][16][17] Improvement of mitochondrial function and promotion of myelin regeneration are considered to be the main mechanisms of ATSO in ameliorating neurological diseases. Although these findings suggested that ATSO may also be beneficial for chemotherapy-induced demyelination, important questions regarding its cytological basis and molecular mechanisms remain to be answered.…”