Transcriptomic and metabolomic signatures of an n-3 polyunsaturated fatty acids supplementation in a normolipidemic/normocholesterolemic Caucasian population

Rudkowska, Iwona; Paradis, Ann-Marie; Thifault, Élisabeth; Julien, Pierre; Tchernof, André; Couture, Patrick; Lemieux, Simone; Barbier, Olivier; Vohl, Marie‐Claude

doi:10.1016/j.jnutbio.2012.01.016

Cited by 63 publications

(71 citation statements)

References 45 publications

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“…This result is in line with whole genome gene expression studies in adults supplemented with n − 3 fatty acids [58,59]. Knowing that NF-κB pathway mediates oxidative stress response [60], the observed reduction in NF-κB gene expression could be a reflection to the observed improvements in the patients' oxidative stress status after supplementation with n−3 fatty acids [19]. The results of the present study might also suggest pathways other than NF-κB gene involved in hydroxyurea well-documented anti-adhesive effects [9].…”

Section: Discussionsupporting

confidence: 84%

Omega 3 (n−3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease

Daak

Elderdery

Elbashir

et al. 2015

Blood Cells, Molecules, and Diseases

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Chronic inflammation and reduced blood levels of omega-3 fatty acids (n−3) are known characteristics of sickle cell disease (SCD).The anti-inflammatory properties of n−3 fatty acids are well recognized. Omega-3 treated (n = 24), hydroxyurea (HU) treated (n = 18), and n−3 untreated (n = 21) homozygous SCD patients (HbSS) and healthy (HbAA) controls (n = 25) matched for age (5-16 years), gender and socioeconomic status were studied. According to age (5-10) or (11-16) years, two or three capsules containing 277.8 mg docosahexaenoic (DHA) and 39.0 mg eicosapentaenoic (EPA) or high oleic acid placebo (41%) were assigned to n − 3 treated and n − 3 untreated groups, respectively. Hydroxyurea treated group was on dosage more than 20 mg/kg/day. The effect of supplementation on systemic and blood cell markers of inflammation was investigated. The n− 3 treated group had higher levels of DHA and EPA (p b 0.001) and lower white blood cell count and monocyte integrin (p b 0.05) compared with the n−3 untreated. No difference was detected between the two groups regarding C-reactive protein, granulocytes integrin and selectin, plasma tumour necrosis factor-α and interleukin-10. The n−3 treated group had lowered nuclear factor-kappa B (NF-κB) gene expression compared to n−3 untreated and HU treated groups (p b 0.05). This study provides evidence that supplementation with n− 3 fatty acids may ameliorate inflammation and blood cell adhesion in patients with SCD.

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Section: Discussionsupporting

confidence: 84%

Omega 3 (n−3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease

Daak

Elderdery

Elbashir

et al. 2015

Blood Cells, Molecules, and Diseases

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“…48,49 Glucose is one of the most abundant metabolites in serum or plasma, and glucose metabolism is also known to be altered in a number of disease states, including diabetes. 8 Although electrolytes (calcium, magnesium, potassium, sodium) are not generally considered in metabolomics investigations, electrolyte imbalances are associated with a number of diseases.…”

Section: Resultsmentioning

confidence: 99%

Development of a Standard Reference Material for Metabolomics Research

et al. 2013

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The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not toward specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research.

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“…Although supplementation with a mixture of EPA and DHA may activate the peroxisome proliferator activated receptor-a pathway in both sexes, the nuclear transcription factor kB pathway appears to be activated in men only (32), which suggests that men and women may respond differently to EPA and DHA supplementation. Our results are not consistent with these data or with our a priori hypothesis that there is a sex-specific anti-inflammatory response to EPA and DHA.…”

Section: Lcn-3pufas and Markers Of Inflammationmentioning

confidence: 99%

A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study

Allaire

Couture²,

Leclerc

et al. 2016

The American Journal of Clinical Nutrition

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Transcriptomic and metabolomic signatures of an n-3 polyunsaturated fatty acids supplementation in a normolipidemic/normocholesterolemic Caucasian population

Cited by 63 publications

References 45 publications

Omega 3 (n−3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease

Omega 3 (n−3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease

Development of a Standard Reference Material for Metabolomics Research

A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study

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