Transcriptomic and Proteomic Analysis of the Epicardial Adipose Tissue

Camarena, Vladimir; Sant, David W.; Huff, Tyler C.; Wang, Gaofeng

doi:10.1007/978-3-030-40570-0_3

Cited by 3 publications

(3 citation statements)

References 114 publications

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“…These results support the cardioprotective effects of physiological EAT via the paracrine or vasocrine secretion of anti-inflammatory adipokines. Simultaneously, they highlight the shift in the epicardial fat secretome equilibrium when adipocyte dysfunction occurs, resulting in the release of proinflammatory adipokines from epicardial adipocytes [94,95]. Patients with CAD also present high levels of MMP-9 expression in EAT, suggesting vascular remodelling processes and vascular smooth muscle migration [96].…”

Section: Proteomic Insights Of Eatmentioning

confidence: 91%

Omics Insights into Epicardial Adipose Tissue: Unravelling Its Molecular Landscape

Mitu,

Popescu,

Dimitriu

et al. 2024

Applied Sciences

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Epicardial adipose tissue (EAT) is a unique fat depot located around the heart, intimately associated with the myocardium and coronary arteries. The secretion of bioactive molecules and their interaction with neighbouring cardiac tissues makes it an active organ with important implications in cardiovascular health and disease. In recent years, omics technologies have provided valuable insights into the molecular characteristics and functional relevance of EAT in patients with coronary atherosclerosis, myocardial infarction, atrial fibrillation and associated metabolic disorders. This review aims to summarize the current understanding of EAT biology through the lens of genomics, transcriptomics, proteomics and lipidomics approaches. We discuss key findings from omics studies on EAT, including gene expression profiles, metabolic activity, signalling pathways and regulatory network, in order to explore in depth the disease mechanisms, possible therapeutic strategies, and cardiovascular risk assessment. Further advances in this field and integrating data from multiple omics platforms hold promise for unlocking personalized cardiometabolic profiles with EAT as a possible biomarker and therapeutic target in cardiovascular disease.

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Section: Proteomic Insights Of Eatmentioning

confidence: 91%

Omics Insights into Epicardial Adipose Tissue: Unravelling Its Molecular Landscape

Mitu,

Popescu,

Dimitriu

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Function (Tromp et al, 2021;Monti, et al, 2020;Iacobellis, 2020). serves as thermogenic source to combat hypothermia and protect the myocardium from temperature variations (Camarena et al, 2020). In addition, EAT facilitates the transport of fatty acids to the myocardium and adapts its metabolic activity to the prevailing conditions and acts as a brown or beige grease reservoir as needed.…”

Section: Thermoregulatory Rolementioning

confidence: 99%

Understanding the impact of left atrial epicardial adipose tissue thickness on atrial fibrillation: A literature review

Fahimi,

Beikmohammadi

2024

AFRJMS

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Atrial Fibrillation (AF) is a common cardiac arrhythmia associated with significant morbidity and mortality. The role of Epicardial Adipose Tissue (EAT), particularly in the left atrium, has garnered attention in the pathophysiology of AF. This review aims to provide an overview of the association between the thickness of left atrial epicardial adipose tissue (LA-EAT) and the incidence of AF, while exploring the arrhythmogenic effects of LA-EAT and the impact of epicardial fat tissue changes with age and in pathological conditions. A comprehensive search of PubMed was conducted, and relevant studies were selected based on their inclusion criteria. The findings suggest that increased LA-EAT thickness is associated with an elevated risk of AF, potentially mediated through inflammatory and proarrhythmic effects. Age-related changes in epicardial fat tissue and alterations in pathological conditions, such as obesity, metabolic syndrome, and cardiovascular diseases, further contribute to the development and progression of AF. Further research is needed to deepen our understanding of these mechanisms and their clinical implications.

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“…function (12,13,14). serves as thermogenic source to combat hypothermia and protect the myocardium from temperature variations (15). In addition, EAT facilitates the transport of fatty acids to the myocardium and adapts its metabolic activity to the prevailing conditions and acts as a brown or beige grease reservoir as needed.…”

Section: Thermoregulatory Rolementioning

confidence: 99%

Understanding the Impact of Left Atrial Epicardial Adipose Tissue Thickness on Atrial Fibrillation: A Literature Review

Fahimi,

Beikmohammadi

2023

Preprint

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Atrial fibrillation (AF) is a common cardiac arrhythmia associated with significant morbidity and mortality. The role of epicardial adipose tissue (EAT), particularly in the left atrium, has garnered attention in the pathophysiology of AF. This review aims to provide an overview of the association between the thickness of left atrial epicardial adipose tissue (LA-EAT) and the incidence of AF, while exploring the arrhythmogenic effects of LA-EAT and the impact of epicardial fat tissue changes with age and in pathological conditions. A comprehensive search of PubMed was conducted, and relevant studies were selected based on their inclusion criteria. The findings suggest that increased LA-EAT thickness is associated with an elevated risk of AF, potentially mediated through inflammatory and proarrhythmic effects. Age-related changes in epicardial fat tissue and alterations in pathological conditions, such as obesity, metabolic syndrome, and cardiovascular diseases, further contribute to the development and progression of AF. Further research is needed to deepen our understanding of these mechanisms and their clinical implications.

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Transcriptomic and Proteomic Analysis of the Epicardial Adipose Tissue

Cited by 3 publications

References 114 publications

Omics Insights into Epicardial Adipose Tissue: Unravelling Its Molecular Landscape

Omics Insights into Epicardial Adipose Tissue: Unravelling Its Molecular Landscape

Understanding the impact of left atrial epicardial adipose tissue thickness on atrial fibrillation: A literature review

Understanding the Impact of Left Atrial Epicardial Adipose Tissue Thickness on Atrial Fibrillation: A Literature Review

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