Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1

Qu, Heshuang; Heinbäck, Rebecka; Salo, Henna; Ewing, Ewoud; Espinosa, Alexander; Aulin, Cecilia; Harris, Helena Erlandsson

doi:10.3390/biom12060779

Cited by 6 publications

(6 citation statements)

References 48 publications

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“…IL-6 is secreted mainly by monocytes/macrophages specifically when polarized to an M1-like phenotype. It was demonstrated also that HMGB1 may polarize macrophages via Toll-like receptor (TLR) 4 [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses

Alghanem¹,

Mansour²,

Shaibah³

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses

Alghanem¹,

Mansour²,

Shaibah³

et al. 2023

Heliyon

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“…found that exogenous lactate has deleterious effects on sepsis patients by mediating the lactylation and acetylation modifications of HMGB1 in macrophages, inducing the release of lactylated/acetylated HMGB1 from cells by exosomal secretion ( 102 ). As an important damage associated molecular pattern (DAMP) molecule, HMGB1 induces macrophage polarization toward the M1 phenotype while maintaining migratory capacity and some M2 characteristics ( 103 ). Subsequently, Du S et al.…”

Section: Lactylation Modifications Are Involved In Regulating Macroph...mentioning

confidence: 99%

Lactate and lactylation in macrophage metabolic reprogramming: current progress and outstanding issues

Xu,

Liu,

et al. 2024

Front. Immunol.

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It is commonly known that different macrophage phenotypes play specific roles in different pathophysiological processes. In recent years, many studies have linked the phenotypes of macrophages to their characteristics in different metabolic pathways, suggesting that macrophages can perform different functions through metabolic reprogramming. It is now gradually recognized that lactate, previously overlooked as a byproduct of glycolytic metabolism, acts as a signaling molecule in regulating multiple biological processes, including immunological responses and metabolism. Recently, lactate has been found to mediate epigenetic changes in macrophages through a newfound lactylation modification, thereby regulating their phenotypic transformation. This novel finding highlights the significant role of lactate metabolism in macrophage function. In this review, we summarize the features of relevant metabolic reprogramming in macrophages and the role of lactate metabolism therein. We also review the progress of research on the regulation of macrophage metabolic reprogramming by lactylation through epigenetic mechanisms.

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“…In the same aspect, loss of HMGB1 in macrophages can increase the differentiation of proinflammatory macrophages and enhance inflammatory response under specific conditions, not the otherwise ( 140 ). In this regard, HMGB1 may induce distinct macrophage phenotypes probably due to different redox isoforms ( 141 ). Besides HMGB1, the expression level of several members of HSPs is closely related to distinct stages of polarization in macrophages ( 142 ).…”

Section: Polarization and Phenotype Of Macrophagesmentioning

confidence: 99%

Macrophages in aseptic loosening: Characteristics, functions, and mechanisms

et al. 2023

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Aseptic loosening (AL) is the most common complication of total joint arthroplasty (TJA). Both local inflammatory response and subsequent osteolysis around the prosthesis are the fundamental causes of disease pathology. As the earliest change of cell behavior, polarizations of macrophages play an essential role in the pathogenesis of AL, including regulating inflammatory responses and related pathological bone remodeling. The direction of macrophage polarization is closely dependent on the microenvironment of the periprosthetic tissue. When the classically activated macrophages (M1) are characterized by the augmented ability to produce proinflammatory cytokines, the primary functions of alternatively activated macrophages (M2) are related to inflammatory relief and tissue repair. Yet, both M1 macrophages and M2 macrophages are involved in the occurrence and development of AL, and a comprehensive understanding of polarized behaviors and inducing factors would help in identifying specific therapies. In recent years, studies have witnessed novel discoveries regarding the role of macrophages in AL pathology, the shifts between polarized phenotype during disease progression, as well as local mediators and signaling pathways responsible for regulations in macrophages and subsequent osteoclasts (OCs). In this review, we summarize recent progress on macrophage polarization and related mechanisms during the development of AL and discuss new findings and concepts in the context of existing work.

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Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1

Cited by 6 publications

References 48 publications

Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses

Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses

Lactate and lactylation in macrophage metabolic reprogramming: current progress and outstanding issues

Macrophages in aseptic loosening: Characteristics, functions, and mechanisms

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