Transcriptomic responses to silver nanoparticles in the freshwater unicellular eukaryote Tetrahymena thermophila

Piersanti, Angela; Juganson, Katre; Mozzicafreddo, Matteo; Wei, Wei; Zhang, Jing; Zhao, Kan; Ballarini, Patrizia; Mortimer, Monika; Pucciarelli, Sandra; Miao, Wei; Miceli, Cristina

doi:10.1016/j.envpol.2020.115965

Cited by 15 publications

(1 citation statement)

References 64 publications

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“…These results were considered to be related to Ag + toxicity in previous studies (Eom and Choi, 2010;Fabrega et al, 2011;Piao et al, 2011) and different between the TiO 2 NP exposure group in this study. Further analysis showed that the total number of DEGs was several times less than in the TiO 2 NP exposure group; this phenomenon was similar to the comparison of Ag NP and AgNO 3 exposure results, but the number of DEGs of AgNO 3 exposure was smaller (Piersanti et al, 2021). Moreover, pathway enrichment was related to apoptosis in A-Ag and C-Ag.…”

Section: Discussionsupporting

confidence: 76%

Effects and Mechanism of Two Nanoparticles (Titanium Dioxide and Silver) to Moina mongolica Daday (Crustacea, Cladocera)

Huang

Lin

2022

Front. Mar. Sci.

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The nearshore and estuary are the main gathering areas of nanoparticles (NPs), and salinity change is a crucial characteristic in these marine areas. Moina mongolica Daday is an important open-ended bait in the nearshore aquaculture environment. Investigating the toxicity mechanism of NPs to M. mongolica under different salinity conditions is crucial to exploring the biological impact of NPs in the nearshore environment. Two typical metal oxide and metal NPs of TiO2 and Ag were used in this study to test the acute, chronic, and reproductive toxicities of M. mongolica (Cladocera) in marine environments of different salinity gradients. The toxic effects and mechanisms of the two NPs on M. mongolica were discussed by ecotoxicology and transcriptional analysis, respectively. A total of 27,274 genes were assembled, and 11,056 genes were successfully compared. Results suggested that TiO2 and Ag NPs showed particle toxicity with oxidation generation and immune emergencies on M. mongolica. Compared with TiO2, Ag NPs showed strong toxicity with reproductive toxicity due to the release of Ag+, resulting in a reduction in reproduction, which is a decrease in the number of offspring and the rm. Critical DEGs involved in carapace showed carapace damage of M. mongolica, due to adhesion and accumulation (approximately 40%–60% of all accumulation) on carapace, which was one of the toxic mechanisms of the two NPs. The salinity factor caused the aggregation of both NPs, and Ag+ release of Ag NPs. The toxicity of TiO2 NPs to M. mongolica increases with salinity, but that of Ag NPs decreases.

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Section: Discussionsupporting

confidence: 76%

Effects and Mechanism of Two Nanoparticles (Titanium Dioxide and Silver) to Moina mongolica Daday (Crustacea, Cladocera)

Huang

Lin

2022

Front. Mar. Sci.

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Unicellular Organisms with Versatile Solutions at the Micro‐Scale: Functional Materials and Principles in Ciliates

Dörr,

Kohl,

Schweikert

et al. 2023

Adv Funct Materials

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Nature's diversity offers an abundance of promising solutions for novel bioinspired functional materials and systems. In particular, single‐celled organisms exhibit solutions and material properties that are realized at the nano‐ and micro‐scales. Ciliates are ubiquitous unicellular eukaryotes that are well‐adapted to a wide range of environmental conditions. They have developed a large variety of interesting and highly specialized characteristics with unique properties and design. In this review, the background of selected ciliate characteristics is highlighted with respect to material properties and structure‐function relationships. Hierarchically complex mineralized structures, highly efficient sensors for movement and protection, shape‐memory structures, as well as survival and detoxification strategies are to be emphasized. Proposed future bioinspired applications of these properties of ciliates expand the possibilities to more sustainable materials and development processes.

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Nanotechnology and Safety Pharmacology

Polaka

Tekade

Jain

2022

Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

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Transcriptomic responses to silver nanoparticles in the freshwater unicellular eukaryote Tetrahymena thermophila

Cited by 15 publications

References 64 publications

Effects and Mechanism of Two Nanoparticles (Titanium Dioxide and Silver) to Moina mongolica Daday (Crustacea, Cladocera)

Effects and Mechanism of Two Nanoparticles (Titanium Dioxide and Silver) to Moina mongolica Daday (Crustacea, Cladocera)

Unicellular Organisms with Versatile Solutions at the Micro‐Scale: Functional Materials and Principles in Ciliates

Nanotechnology and Safety Pharmacology

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