Transcriptomic signature of luteinized cumulus cells of oocytes developing to live birth after women received intracytoplasmic sperm injection

Sachs, Maike K.; Makieva, Sofia; Velasco Gil, Ana; Xie, Min; Ille, Fabian; Salvadori, Vincent; Schmidhauser, Meret; Saenz-de-Juano, Mara D.; Ulbrich, Susanne E.; Leeners, Brigitte

doi:10.1016/j.xfss.2023.11.004

Cited by 1 publication

(2 citation statements)

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“…This study, conducted using a microarray platform, similarly found no discernible differences in gene expression that could predict either oocyte fertilization or embryo implantation [ 88 ]. Moreover, recently, Sachs and colleagues [ 89 ] compared the transcriptome of CCs obtained from oocytes that resulted in pregnancy, did not result in pregnancy, led to live birth, or did not result in live birth. Although the RNA sequencing analysis did not uncover differentially expressed genes (DEGs) when comparing the transcriptomic profiles of the groups “no pregnancy” with “pregnancy”, they identified 139 DEGs when comparing the subset of “pregnancy only” with “live birth”.…”

Section: Molecular Markers Of Embryo Qualitymentioning

confidence: 99%

“…Although the RNA sequencing analysis did not uncover differentially expressed genes (DEGs) when comparing the transcriptomic profiles of the groups “no pregnancy” with “pregnancy”, they identified 139 DEGs when comparing the subset of “pregnancy only” with “live birth”. Notably, 28 of these differentially expressed genes were associated with clusters crucial for successful ART outcomes, such as CTGF, SERPINE2, PCK1, HHIP, HS3ST, and BIRC5 [ 89 ].…”

Section: Molecular Markers Of Embryo Qualitymentioning

confidence: 99%

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When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation

Lacconi,

Massimiani,

Carriero

et al. 2024

IJMS

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Evaluation of the optimal number of embryos, their quality, and the precise timing for transfer are critical determinants in reproductive success, although still remaining one of the main challenges in assisted reproduction technologies (ART). Indeed, the success of in vitro fertilization (IVF) treatments relies on a multitude of events and factors involving both the endometrium and the embryo. Despite concerted efforts on both fronts, the overall success rates of IVF techniques continue to range between 25% and 30%. The role of the endometrium in implantation has been recently recognized, leading to the hypothesis that both the “soil” and the “seed” play a central role in a successful pregnancy. In this respect, identification of the molecular signature of endometrial receptivity together with the selection of the best embryo for transfer become crucial in ART. Currently, efforts have been made to develop accurate, predictive, and personalized tests to identify the window of implantation and the best quality embryo. However, the value of these tests is still debated, as conflicting results are reported in the literature. The purpose of this review is to summarize and critically report the available criteria to optimize the success of embryo transfer and to better understand current limitations and potential areas for improvement.

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Section: Molecular Markers Of Embryo Qualitymentioning

confidence: 99%

Section: Molecular Markers Of Embryo Qualitymentioning

confidence: 99%