Transcriptomics and metabonomics study on the effect of exercise combined with curcumin supplementation on breast cancer in mice

Guo, Yong; Su, Jinxing; Jiang, Shangquan; Xu, Yan; Dou, Binbin; Li, Ting; Zhu, Jiabin; He, Kan

doi:10.1016/j.heliyon.2024.e28807

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e28807

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Transcriptomics and metabonomics study on the effect of exercise combined with curcumin supplementation on breast cancer in mice

Yong Guo,

Jinxing Su,

Shangquan Jiang

et al.

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Cited by 3 publications

References 65 publications

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Curcumin and its nano‐formulations combined with exercise: From molecular mechanisms to clinic

Liu,

Wang,

Guo

et al. 2024

Cell Biochemistry & Function

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Curcumin is a strong substance derived from turmeric, a popular spice, renowned for its antioxidant and anti‐inflammatory abilities. The study delved deeply into a thorough examination of various sources to evaluate the impact of both regular curcumin and nano‐formulated curcumin on elements that impact physical performance, including muscular strain, discomfort, swelling, and oxidative tension. While engaging in exercise, the body experiences a rise in reactive oxygen species and inflammation. As a result, it is important to ensure a proper balance between internal and external sources of antioxidants to maintain stability in the skeletal muscle. Without this balance, there is a risk of muscle soreness, damage, and ultimately, a decline in exercise performance. Curcumin possesses the ability to enhance physical performance and reduce the symptoms of muscle fatigue and injury by virtue of its antioxidative and anti‐inflammatory properties. Including curcumin supplements appears to have advantageous effects on various aspects of exercise, such as enhancing performance, assisting with recovery, lessening muscle damage and discomfort, and lowering levels of inflammation and oxidative stress. However, a thorough assessment is necessary to precisely gauge the healing advantages of curcumin in enhancing exercise ability and reducing recovery time.

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Curcumin and its nano‐formulations combined with exercise: From molecular mechanisms to clinic

Liu,

Wang,

Guo

et al. 2024

Cell Biochemistry & Function

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Targeting the Akt signaling pathway: Exploiting curcumin's anticancer potential

Aliyari,

Hashemy,

Hashemi

et al. 2024

Pathology - Research and Practice

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Curcumin Administration Routes in Breast Cancer Treatment

Mayo,

Penroz,

Torres

et al. 2024

IJMS

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Breast cancer is a public health concern worldwide, characterized by increasing incidence and mortality rates, requiring novel and effective therapeutic strategies. Curcumin is a bioactive compound extracted from turmeric with several pharmacological activities. Curcumin is a multifaceted anticancer agent through mechanisms including the modulation of signaling pathways, inhibition of cell proliferation, induction of apoptosis, and production of reactive oxygen species. However, the poor water solubility and bioavailability of curcumin create important barriers in its clinical application. This review elaborates on the therapeutic potential of curcumin in breast cancer treatment, focusing on the efficacy of different administration routes and synergistic effects with other therapeutic agents. The intravenous administration of curcumin-loaded nanoparticles significantly improves bioavailability and therapeutic outcomes compared to oral routes. Innovative formulations, such as nano-emulsifying drug delivery systems, have shown promise in enhancing oral bioavailability. While intravenous delivery ensures higher bioavailability and direct action on tumor cells, it is more invasive and expensive than oral administration. Advancing research on curcumin in breast cancer treatment is essential for improving therapeutic outcomes and enhancing the quality of life of patients.

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Transcriptomics and metabonomics study on the effect of exercise combined with curcumin supplementation on breast cancer in mice

Cited by 3 publications

References 65 publications

Curcumin and its nano‐formulations combined with exercise: From molecular mechanisms to clinic

Curcumin and its nano‐formulations combined with exercise: From molecular mechanisms to clinic

Targeting the Akt signaling pathway: Exploiting curcumin's anticancer potential

Curcumin Administration Routes in Breast Cancer Treatment

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