Abstract:The present study is to explore the anticancer effect of loonamycin (LM) in vitro and in vivo, and investigate the underlying mechanism with combined multi-omics. LM exhibited anticancer activity in human triple negative breast cancer cells by promoting cell apoptosis. LM administration inhibited the growth of MDA-MB-468 tumors in a murine xenograft model of breast cancer. Mechanistic studies suggested that LM could inhibit the topoisomerase I in a dose-dependent manner in vitro experiments. Combined with the … Show more
“…X. Sun et al described the application of transcriptomics and proteomics in the investigation of the anticancer mechanisms of loonamycin, a derivative of rebeccamycin, in breast cancer [ 6 ]. In the field of natural compounds of marine origin, L. Sun et al explored the bioactive sesquiterpenoids isolated from Aspergillus sp.…”
“…X. Sun et al described the application of transcriptomics and proteomics in the investigation of the anticancer mechanisms of loonamycin, a derivative of rebeccamycin, in breast cancer [ 6 ]. In the field of natural compounds of marine origin, L. Sun et al explored the bioactive sesquiterpenoids isolated from Aspergillus sp.…”
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