2022
DOI: 10.3390/molecules27206958
|View full text |Cite
|
Sign up to set email alerts
|

Transcriptomics and Proteomics Characterizing the Anticancer Mechanisms of Natural Rebeccamycin Analog Loonamycin in Breast Cancer Cells

Abstract: The present study is to explore the anticancer effect of loonamycin (LM) in vitro and in vivo, and investigate the underlying mechanism with combined multi-omics. LM exhibited anticancer activity in human triple negative breast cancer cells by promoting cell apoptosis. LM administration inhibited the growth of MDA-MB-468 tumors in a murine xenograft model of breast cancer. Mechanistic studies suggested that LM could inhibit the topoisomerase I in a dose-dependent manner in vitro experiments. Combined with the … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
1
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(1 citation statement)
references
References 38 publications
0
1
0
Order By: Relevance
“…X. Sun et al described the application of transcriptomics and proteomics in the investigation of the anticancer mechanisms of loonamycin, a derivative of rebeccamycin, in breast cancer [ 6 ]. In the field of natural compounds of marine origin, L. Sun et al explored the bioactive sesquiterpenoids isolated from Aspergillus sp.…”
mentioning
confidence: 99%
“…X. Sun et al described the application of transcriptomics and proteomics in the investigation of the anticancer mechanisms of loonamycin, a derivative of rebeccamycin, in breast cancer [ 6 ]. In the field of natural compounds of marine origin, L. Sun et al explored the bioactive sesquiterpenoids isolated from Aspergillus sp.…”
mentioning
confidence: 99%