Transcutaneous auricular VNS applied to experimental pain: A paired behavioral and EEG study using thermonociceptive CO2 laser

Dumoulin, Manon; Liberati, Giulia; Mouraux, André; Santos, Susana Ferrão; Tahry, Riëm El

doi:10.1371/journal.pone.0254480

Cited by 7 publications

(3 citation statements)

References 119 publications

(258 reference statements)

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“…Most of the studies analyzed ERP metrics on this review. Among the common oscillation assessments during events we detected early events, such as P100 [ 34 ], P180 [ 33 ], P200 [ 27 , 34 ], P300 [ 28 , 29 , 33 , 36 , 40 , 42 , 43 ], and N200 [ 27 , 28 , 34 , 36 ], and late events, such as P600 [ 33 ], N400 [ 35 ], and N450 [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Electroencephalographic Patterns in taVNS: A Systematic Review

et al. 2022

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Transcutaneous auricular vagus nerve stimulation (taVNS) is a newer delivery system using a non-invasive stimulation device placed at the ear. taVNS research is focused on clinical trials showing potential therapeutic benefits, however the neurophysiological effects of this stimulation on brain activity are still unclear. We propose a systematic review that aims to describe the effects of taVNS on EEG measures and identify taVNS parameters that can potentially lead to consistent EEG-mediated biomarkers for this therapy. A systematic literature review was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) and the Cochrane handbook for systematic reviews. Clinical trials examining EEG parameters were considered, including absolute and relative power, coherence, degree of symmetry, evoked potentials, and peak frequency of all bands. According to our criteria, 18 studies (from 122 articles) were included. Our findings show a general trend towards increased EEG power spectrum activity in lower frequencies, and changes on early components of the ERP related to inhibitory tasks. This review suggests that quantitative electroencephalography can be used to assess the effects of taVNS on brain activity, however more studies are needed to systematically establish the specific effects and metrics that would reflect the non-invasive stimulation through the auricular branch of the vagus nerve.

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Section: Resultsmentioning

confidence: 99%

Electroencephalographic Patterns in taVNS: A Systematic Review

et al. 2022

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“…( A ) Non-invasive auricular branch VNS stimulation (as described in Dumoulin et al . 32 ). ( B ) Baroreceptor activation therapy.…”

Section: Management Of Cardiac Channelopathies With Focus On Neuromod...mentioning

confidence: 99%

The proarrhythmogenic role of autonomics and emerging neuromodulation approaches to prevent sudden death in cardiac ion channelopathies

Tonko,

Lambiase

2024

Cardiovascular Research

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Ventricular arrhythmias in cardiac channelopathies are linked to autonomic triggers, which are sub-optimally targeted in current management strategies. Improved molecular understanding of cardiac channelopathies and cellular autonomic signalling could refine autonomic therapies to target the specific signalling pathways relevant to the specific aetiologies as well as the central nervous system centres involved in the cardiac autonomic regulation. This review summarizes key anatomical and physiological aspects of the cardiac autonomic nervous system and its impact on ventricular arrhythmias in primary inherited arrhythmia syndromes. Proarrhythmogenic autonomic effects and potential therapeutic targets in defined conditions including the Brugada syndrome, early repolarization syndrome, long QT syndrome, and catecholaminergic polymorphic ventricular tachycardia will be examined. Pharmacological and interventional neuromodulation options for these cardiac channelopathies are discussed. Promising new targets for cardiac neuromodulation include inhibitory and excitatory G-protein coupled receptors, neuropeptides, chemorepellents/attractants as well as the vagal and sympathetic nuclei in the central nervous system. Novel therapeutic strategies utilizing invasive and non-invasive deep brain/brain stem stimulation as well as the rapidly growing field of chemo-, opto-, or sonogenetics allowing cell-specific targeting to reduce ventricular arrhythmias are presented.

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“…For example, 1 alternative and complementary hypothesis is that concurrent activation of the anti-inflammatory system cascade may account for the measurable reduction in pain intensity. 5,7,14,34,42…”

Section: Pain Reduction Mechanism Of Transcutaneous Vagus Nerve Stimu...mentioning

confidence: 99%

Transcutaneous vagus nerve stimulation effects on chronic pain: systematic review and meta-analysis

Costa,

Gianlorenço,

Andrade

et al. 2024

PR9

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Chronic pain is one of the major causes of disability with a tremendous impact on an individual's quality of life and on public health. Transcutaneous vagus nerve stimulation (tVNS) is a safe therapeutic for this condition. We aimed to evaluate its effects in adults with chronic pain. A comprehensive search was performed, including randomized controlled trials published until October 2023, which assessed the effects of noninvasive tVNS. Cohen's d effect size and 95% confidence intervals (CIs) were calculated, and random-effects meta-analyses were performed. Fifteen studies were included. The results revealed a mean effect size of 0.41 (95% CI 0.17-0.66) in favor of tVNS as compared with control, although a significant heterogeneity was observed (χ2 = 21.7, df = 10, P = 0.02, I 2 = 53.9%). However, when compared with nonactive controls, tVNS shows a larger effect size (0.79, 95% CI 0.25-1.33), although the number of studies was small (n = 3). When analyzed separately, auricular tVNS and cervical tVNS against control, it shows a significant small to moderate effect size, similar to that of the main analysis, respectively, 0.42 (95% CI 0.08-0.76, 8 studies) and 0.36 (95% CI 0.01-0.70, 3 studies). No differences were observed in the number of migraine days for the trials on migraine. This meta-analysis indicates that tVNS shows promise as an effective intervention for managing pain intensity in chronic pain conditions. We discuss the design of future trials to confirm these preliminary results, including sample size and parameters of stimulation.

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Transcutaneous auricular VNS applied to experimental pain: A paired behavioral and EEG study using thermonociceptive CO2 laser

Cited by 7 publications

References 119 publications

Electroencephalographic Patterns in taVNS: A Systematic Review

Electroencephalographic Patterns in taVNS: A Systematic Review

The proarrhythmogenic role of autonomics and emerging neuromodulation approaches to prevent sudden death in cardiac ion channelopathies

Transcutaneous vagus nerve stimulation effects on chronic pain: systematic review and meta-analysis

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