Transcutaneous Carbon Dioxide Treatment Is Capable of Reducing Peripheral Vascular Resistance in Hypertensive Patients

Abstract

Aim: We aimed to investigate the effects of a single carbon dioxide (CO 2) treatment on arterial stiffness by monitoring the changes of aortic pulse-wave velocity (PWV) and aortic augmentation index (AIXao), which are indicators of arterial stiffness. Patients and Methods: PWV and AIXao were measured by an invasively validated oscillometric device. The measurements of stiffness parameters were performed before the CO 2 treatment, and at 1, 4 and 8 h after the first treatment. Results: Thirty-one patients were included. No significant changes were found in PWV. AIXao decreased significantly 1 h and 4 h after CO 2 treatment compared to baseline values (p=0.034 and p<0.001). AIXao increased 8 h after the CO 2 treatment, but remained significantly lower than baseline AIXao values (p=0.016). Conclusion: CO 2 treatment is capable of reducing peripheral vascular resistance. We hypothesize that CO 2 is not only a temporal vasodilator but is also capable of activating vasodilation pathways.

Use of dry carbonic acid gas baths to correct human biological age

“…Subsequent to the DCAGB course exposure, most parameters reflecting the level of the LP processes showed significant oppression of the process, additionally elimination of the metabolic acidosis developed during the aging of the organism was observed, as well as increased alkaline reserve and improved peripheral blood oxygenation, which together contributed to the reduction of biological and cardiopulmonal age of patients. Effect of CO2 on cardiopulmonal biological age of elderly and senile patients (Figure 3) might be associated with reduced peripheral vascular resistance or activation of vasodilatation [13] and with regulation of heart rhythm frequency mediated through the effects of CO2 on the autonomic nervous system [27].…”

“…Literature contains information on the role of CO2 in organism metabolism and functions regulation of its systems, on the presence of antioxidant properties of CO2; several mechanisms of its influence on the lipid peroxidation processes in animals and humans are presented etc. [12,13,14,15]. At the same time, the role of CO2 in the regulation of aging and biological age change is not sufficiently covered in the literature.…”

CO2-Trockengasbäder verändern den topischen pH-Wert auf Wundflächen und intakter Haut

“…Die präkapillare Vasodilatation durch die transkutane CO 2 Applikation bleibt hier selektiv auf das exponierte Hautareal beschränkt und ist bereits ab Werten um 500 mg CO 2 /l zu erken nen [5]. Ebenso ändert sich die GefäßCompliance mit verringer tem Gefäßwiderstand durch CO 2 Therapie bei Patienten mit arte riellem Hypertonus [11]. Die Erhöhung der lokalen Zirkulation durch Vasodilatation, die Verbesserung der Durchblutung, die Re duktion des Gefäßwiderstandes sowie die erhöhte Abgabe von O 2 in das umliegende Gewebe ist in vivo doppelblindrandomisiert bei zahlreichen angiologischen Erkrankungen als auch gesunden Pro banden nachgewiesen [8,10,12,13].…”

Kohlendioxid-Bäder (CO2-Bäder)

“…Dabei ist zu betonen, dass dieser Effekt unmittelbar auftritt, was durch Messungen des kapillaren Querschnitts nachgewiesen wurde [10]. Ebenso ändert sich die Gefäß-Compliance mit verringertem Gefäßwiderstand durch CO 2 -Therapie bei Patienten mit arteriellem Hypertonus [11].…”