Transcutaneous oxygen tension measurements as a method of assessing peripheral vascular decease

Young, K C; Railton, R.; Harrower, A. D. B.; Brookes, R W

doi:10.1088/0143-0815/2/2/007

Cited by 11 publications

(3 citation statements)

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“…We have reported previously a reduction in TcPO2 values at 45 ~ in patients with peripheral vascular disease [4], but whether such abnormalities in TcPO2 can be detected in diabetic patients with no clinical evidence of vascular disease is unknown. Reduction in vascular reactivity in diabetic children has been reported [5] and we have, therefore, investigated a group of adult Type 1 (insulin-dependent) diabetic patients to determine whether there are any differences in TcPO2 or in vascular reactivity compared with normal subjects.…”

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“…If the vascular bed is maximally dilated by heating to 45 ~ and adequately perfused, there is a good correlation between TcPO2 values and arterial PO2 in healthy adults [2]. With the electrode operating at a lower temperature (usually 37 ~ the TcPO2 reading is then related to skin perfusion and the technique can be used to assess reactive hyperaemia in the skin [3].We have reported previously a reduction in TcPO2 values at 45 ~ in patients with peripheral vascular disease [4], but whether such abnormalities in TcPO2 can be detected in diabetic patients with no clinical evidence of vascular disease is unknown. Reduction in vascular reactivity in diabetic children has been reported [5] and we have, therefore, investigated a group of adult Type 1 (insulin-dependent) diabetic patients to determine whether there are any differences in TcPO2 or in vascular reactivity compared with normal subjects.…”

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confidence: 99%

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Reduced transcutaneous oxygen tension and impaired vascular response in type 1 (insulin-dependent) diabetes

Railton¹,

Newman²,

Hislop

et al. 1983

Diabetologia

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Summary. Measurements of transcutaneous oxygen tension were made on the foot and arm in 16 Type 1 (insulin-dependent) diabetic patients with no evidence of vascular or neurological disease on simple clinical examination and in 30 nondiabetic subjects. The mean transcutaneous oxygen tension measured at 45 ~ on the foot was significantly lower in the diabetic patients than in the non-diabetic subjects. The hyperaemic response in the arm after cuff occlusion (measured by transcutaneous oxygen tension at 37 ~ was also significantly lower in the diabetic patients. These results may reflect abnormal capillary blood flow in diabetic patients. As the methods are simple and non-invasive, they may prove useful in the early assessment and subsequent monitoring of peripheral vascular problems in diabetes.Key words: Transcutaneous oxygen tension, vascular response, Type 1 diabetes, capillary blood flow.The technique of transcutaneous oxygen tension (TcPO2) measurement can provide a non-invasive method of estimating both arterial PO2 and tissue perfusion [1]. If the vascular bed is maximally dilated by heating to 45 ~ and adequately perfused, there is a good correlation between TcPO2 values and arterial PO2 in healthy adults [2]. With the electrode operating at a lower temperature (usually 37 ~ the TcPO2 reading is then related to skin perfusion and the technique can be used to assess reactive hyperaemia in the skin [3].We have reported previously a reduction in TcPO2 values at 45 ~ in patients with peripheral vascular disease [4], but whether such abnormalities in TcPO2 can be detected in diabetic patients with no clinical evidence of vascular disease is unknown. Reduction in vascular reactivity in diabetic children has been reported [5] and we have, therefore, investigated a group of adult Type 1 (insulin-dependent) diabetic patients to determine whether there are any differences in TcPO2 or in vascular reactivity compared with normal subjects. Patients and MethodsSixteen Type 1 diabetic patients, eight females and eight males, mean +SD age 28_6years (range 18-39years) were studied (Tablet). None had any symptoms of leg pain or claudication and all had palpable lower limp pulses including dorsalis pedis and posterior tibial pulses. Lower limb reflexes, pin prick and touch sensation and ankle vibration sense using a tuning fork (128 Hz) were also normal in all patients. Thirty normal subjects (11 females and 19 males) aged from 20 to 63 years were also studied. Twenty-two of this group (11 females and It males) were aged < 40 years (mean + SD: 28.4 + 6.1 years) and were used as control subjects. All gave informed consent. Six of the diabetic patients and 11 of the control subjects were regular smokers of 20-40 cigarettes daily. All subjects refrained from smoking for a minimum of 1 h before the procedure and were studied supine. The left arm and left foot were exposed and clothing loosened around the arm and leg to prevent any obstruction to blood flow. The examination room was maintained close to 26 ~ to prevent vasoconstri...

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confidence: 99%

Reduced transcutaneous oxygen tension and impaired vascular response in type 1 (insulin-dependent) diabetes

Railton¹,

Newman²,

Hislop

et al. 1983

Diabetologia

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“…People with spinal cord injuries (SCIs) are at high risk of skin breakdown because both limited mobility and sensation are commonly associated with such injuries. Researchers have estimated that 50% to 85% of individuals with SCI will develop a pressure ulcer in their lifetime (1)(2)(3). Annual treatment costs in the United States for pressure ulcers in this population are approximately 1.3 billion, accounting for 25% of the total cost of medical care after SCI (4).…”

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Load Redistribution in Variable Position Wheelchairs in People With Spinal Cord Injury

Sprigle

Maurer

Soneblum

2010

The Journal of Spinal Cord Medicine

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Background/Objective: Tilt and recline variable position seating systems are most commonly used for pressure relief to decrease potential for skin breakdown. This study provides quantitative information on the magnitudes of loading on the seat and back during phases of tilt, recline, and standing. The objective of this study was to show that the amount of force reduction at the seat would differ across these 3 methods within their respective clinical ranges. Participants: Six able-bodied (AB) subjects (2 men, 4 women) with a median age of 25 years, and 10 subjects (8 men, 2 women) with spinal cord injury (SCI) with a median age of 35.5 years. Methods: Subjects sat on a power wheelchair with Tekscan pressure mats placed underneath a foam backrest and cushion. Data were collected at 5 positions for each method. Order of position and method tested were randomized. Linear regressions were used to calculate the relationships of normalized seat and backrest forces to seat and backrest angles for each chair configuration. Results: Normalized seat loads had strong linear relationships with the angles of change in tilt, recline, and standing for both groups. Maximum decreases in seat load occurred at full standing and full recline in the SCI subjects and in full standing in the AB subjects. Loads linearly increased on the back during tilt and recline and linearly decreased during standing for both groups. Conclusions: Standing and recline offered similar seat load reductions at their respective terminal positions. Standing also reduced loading on the backrest. Recognizing that each method had clinical benefits and drawbacks, the results of this study indicate that tilt, recline, and standing systems should be considered as a means of weight shifting for wheelchair users.

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Effects of Compressive Loading Regimens on Tissue Viability

Bader¹

1990

Pressure Sores - Clinical Practice and Scientific Approach

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Transcutaneous oxygen tension measurements as a method of assessing peripheral vascular decease

Cited by 11 publications

References 3 publications

Reduced transcutaneous oxygen tension and impaired vascular response in type 1 (insulin-dependent) diabetes

Reduced transcutaneous oxygen tension and impaired vascular response in type 1 (insulin-dependent) diabetes

Load Redistribution in Variable Position Wheelchairs in People With Spinal Cord Injury

Effects of Compressive Loading Regimens on Tissue Viability

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