Transcutaneous Ultrasound Augments Lysis of Arterial Thrombi In Vivo

Luo, Hao; Nishioka, Toshihiko; Fishbein, Michael C.; Cercek, Bojan; Forrester, James S.; Kim, Chong‐Jin; Berglund, Hans; Siegel, Robert J.

doi:10.1161/01.cir.94.4.775

Cited by 116 publications

(62 citation statements)

References 15 publications

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“…Ultrasound has been demonstrated to enhance thrombolysis when used in conjunction with a thrombolytic agent both in vitro and in vivo [23][24][25][26][27]. Ultrasound delivered intravascularly through miniaturized transducers attached to a catheter has demonstrated effective and safe thrombolysis [28].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes

Tiukinhoy-Laing¹,

Huang²,

Klegerman³

et al. 2007

Thrombosis Research

122

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Introduction-Targeted delivery of thrombolytics to the site of occlusion is an attractive concept, with implications for the treatment of many thrombo-occlusive diseases. Ultrasound enhances thrombolysis, which can be augmented by the addition of a contrast agent. We have previously reported development of echogenic liposomes (ELIP) for targeted highlighting of structures with potential for drug and gene delivery. This study evaluated the potential of ELIP for thrombolytic loading, and the effect of ultrasound exposure of thrombolytic-loaded ELIP on thrombolytic efficacy.

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Section: Discussionmentioning

confidence: 99%

Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes

Tiukinhoy-Laing¹,

Huang²,

Klegerman³

et al. 2007

Thrombosis Research

122

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show abstract

“…[1][2][3] However, these studies used transducers not certified for in vivo application. Limitations for in vivo usage of high-frequency ultrasound are potential tissue damage caused by heating, 4,5 when applied at high ultrasound intensities, and further, a limited penetration of tissues, for example, the cranial bone. 6,7 Advantages are a high-resolution for imaging and a possible combined diagnostic and therapeutic in vivo application using the same transducer, 8 which could be implemented by the usage of commercially available ultrasound devices following US Food and Drug Administration output intensity limitations (maximum 720 mW/cm 2 ) to guarantee a safe application.…”

mentioning

confidence: 99%

Can a Commercial Diagnostic Ultrasound Device Accelerate Thrombolysis?

Pfaffenberger

Devcic-Kuhar

Kollmann

et al. 2005

Stroke

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“…[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] US thrombolytic therapy with the use of an intravascular catheter has also been performed, which leads to earlier recanalization. 22,23 We have previously reported that low-frequency, low-intensity US penetrates the cranium and enhances thrombolysis in vitro.…”

mentioning

confidence: 99%

Can Transcranial Ultrasonication Increase Recanalization Flow With Tissue Plasminogen Activator?

Ishibashi

Aoki

Onoue

et al. 2002

Stroke

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Background and Purpose-In thrombolytic therapy for acute ischemic stroke, it is essential to obtain rapid thrombolysis before ischemic neuronal injury occurs. To develop a new technique of thrombolysis for acute ischemic stroke, the effect of transcranially applied ultrasound (TUS) on thrombolysis was examined. Methods-An occlusion model of rabbit femoral artery was produced with thrombin after establishment of stenotic flow and endothelial damage. After stable occlusion was confirmed, monteplase (mtPA) was administered intravenously, and ultrasound (490 kHz, 0.13 W/cm 2 ) was applied through a piece of temporal bone (TUS group; nϭ9). The control group received mtPA alone (tissue plasminogen activator [tPA] group; nϭ12). To verify the efficacy of TUS, femoral artery flow was measured during the procedure. Results-The recanalization ratio was 16.7% (2 of 12) in the tPA group and 66.7% (6 of 9) in the TUS group. The recanalization ratio in the TUS group was higher than that in the tPA group (Pϭ0.03). Patency flow ratio, which was defined as recanalization flow divided by baseline flow, of the TUS group (44.6Ϯ13.9%) was significantly greater than that of the tPA group (9.9Ϯ6.8%) at 60 minutes (Pϭ0.025). Patency flow ratio became higher in the TUS group than in the tPA group between 20 and 30 minutes from the start of thrombolysis. Conclusions-Low-frequency and low-intensity TUS enhanced thrombolysis by mtPA in a rabbit femoral artery occlusion model. This technique should be clinically useful for thrombolysis in acute ischemic stroke.

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Transcutaneous Ultrasound Augments Lysis of Arterial Thrombi In Vivo

Abstract: In vivo transcutaneous ultrasound significantly augments lysis of thrombi with streptokinase in rabbit iliofemoral arteries.

Cited by 116 publications

References 15 publications

Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes

Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes

Can a Commercial Diagnostic Ultrasound Device Accelerate Thrombolysis?

Can Transcranial Ultrasonication Increase Recanalization Flow With Tissue Plasminogen Activator?

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