2017
DOI: 10.1155/2017/7876507
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Transcutaneous Vagus Nerve Stimulation Combined with Robotic Rehabilitation Improves Upper Limb Function after Stroke

Abstract: The efficacy of standard rehabilitative therapy for improving upper limb functions after stroke is limited; thus, alternative strategies are needed. Vagus nerve stimulation (VNS) paired with rehabilitation is a promising approach, but the invasiveness of this technique limits its clinical application. Recently, a noninvasive method to stimulate vagus nerve has been developed. The aim of the present study was to explore whether noninvasive VNS combined with robotic rehabilitation can enhance upper limb function… Show more

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Cited by 106 publications
(155 citation statements)
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“…FMA-U was deemed a core outcome in stroke recovery [ 39 ], and this change was considered clinically significant in stroke patients [ 40 ]. Indeed, a similar change of FMA-U was found in other clinic trials [ 6 , 7 , 10 , 12 ]. Interestingly, the changes from FMA-U are larger in implanted VNS trials [ 6 , 7 ].…”
Section: Discussionsupporting
confidence: 83%
See 1 more Smart Citation
“…FMA-U was deemed a core outcome in stroke recovery [ 39 ], and this change was considered clinically significant in stroke patients [ 40 ]. Indeed, a similar change of FMA-U was found in other clinic trials [ 6 , 7 , 10 , 12 ]. Interestingly, the changes from FMA-U are larger in implanted VNS trials [ 6 , 7 ].…”
Section: Discussionsupporting
confidence: 83%
“…The left auricular branch vagus nerve was stimulated by the modified dot-like electrodes that were fitted to the cymba conchae ( Figure 2(a) ). The parameters were selected as follows: 600 pulses (intratrain pulse frequency = 20 Hz; pulse duration = 0.3 ms), lasting 30 seconds each time, stimulating once every 5 minutes [ 12 ]. Intensity of taVNS was individually selected by the patients according to tolerance.…”
Section: Methodsmentioning
confidence: 99%
“…The data in both animals and adult humans are convincing in that VNS paired with a stimulus improves functioning (Porter et al, 2012;Khodaparast et al, 2013Khodaparast et al, , 2014Khodaparast et al, , 2016Dawson et al, 2016;Capone et al, 2017;Meyers et al, 2018). In our neonates with brain dysmaturity or overt brain injury, neuromodulation of abnormal circuits may positively influence neuronal connectivity and neuroplasticity (Kilgard, 2012;Meyers et al, 2018).…”
Section: Discussionmentioning
confidence: 70%
“…Systemic effects of aVNS are additionally supported by improvement of metabolic processes (Richards and Marley, 1998 ; Cabýoglu et al, 2006 ; Huang et al, 2014 ; Ju et al, 2014 ; Schukro et al, 2014 ), attenuation of neurological disorders (Kraus et al, 2007 ; Hein et al, 2013 ; Lehtimäki et al, 2013 ; Kampusch et al, 2015 ; Bauer et al, 2016 ; Fang et al, 2016 ; Rong et al, 2016 ; Capone et al, 2017 ; Ylikoski et al, 2017 ) and enhancement of cognitive performances (Rong et al, 2012 ; Jacobs et al, 2015 ) as well as by pain relief effects (Sator-Katzenschlager et al, 2003 , 2004 ; Napadow et al, 2012 ; Chakravarthy et al, 2015 ; Kox et al, 2015 ; Kwan et al, 2016 ; French et al, 2017 ; Hoover, 2017 ; Kovacic et al, 2017 ; Kaniusas et al, 2019a , b ).…”
Section: Resultsmentioning
confidence: 99%