Transcutaneous vs. Intraoperative Quantitative Ultrasound for Staging Bovine Hepatic Steatosis

Weijers, Gert; Starke, A.; Thijssen, J.M.; Haudum, A.; Wohlsein, P.; Rehage, J.; Korte, Chris L. de

doi:10.1016/j.ultrasmedbio.2012.04.009

Cited by 30 publications

(35 citation statements)

References 21 publications

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“…In a subsequent study, it was also proven that transcutaneous US yielded results similar to those with intra-operative application and that a TMP could serve as a reference instead of a group of healthy patients (Weijers et al 2012). …”

Section: Introductionmentioning

confidence: 89%

“…All CAUS image pre-and post-processing steps applied are fully described in recent articles Thijssen et al 2008;Weijers et al 2010;2012). Briefly, the post-processing look-up table (LUT) was chosen to be linear to obtain pure logarithmically compressed echo levels in B-mode images (Thijssen et al 2007).…”

Section: Mrs Reference Measurementsmentioning

confidence: 99%

“…This pilot study was undertaken to investigate whether the computer-aided ultrasound (CAUS) method, which was developed and tested for staging the hepatic fat content in cows, can be used to quantify liver fat content in patients on HPN Thijssen et al 2008;Weijers et al 2010;2012).…”

Section: Introductionmentioning

confidence: 99%

“…A thicker fat layer absorbs more of the energy of the ultrasound signal before it reaches the liver and affects the mean echo level backscattered from the liver, so correction for the fat layer thickness is required. We assumed an overall attenuation by skin and subcutaneous layers of 1 dB/cm/MHz (Weijers et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Ultrasound for Staging of Hepatic Steatosis in Patients on Home Parenteral Nutrition Validated with Magnetic Resonance Spectroscopy: A Feasibility Study

Weijers

Wanten

Thijssen

et al. 2016

Ultrasound in Medicine & Biology

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Patients on home parenteral nutrition are at risk for developing liver dysfunction, which is due partly to the accumulation of lipids in the liver (steatosis) and may progress to end-stage liver disease with overt liver failure. Therefore, a timely diagnosis with easy access to repeated assessment of the degree of liver steatosis is of great importance. A pilot study was performed in 14 patients on long-term home parenteral nutrition using the computer-aided ultrasound method. Ultrasound radio frequency data were acquired using a phased array transducer and were converted into conventional B-mode images. All patients were subjected to proton magnetic resonance spectroscopy measurement of liver fat content for reference. Computer-aided ultrasound parameters similar to those in a previous validation study in cows revealed significant correlations with fat content measured by magnetic resonance spectroscopy. The most significant parameters were the residual attenuation coefficient (R = 0.95, p< 0.001) and the lateral speckle size (R = 0.77, p = 0.021). These findings indicate the potential usefulness of computer-aided ultrasound for staging of hepatic steatosis.

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Section: Introductionmentioning

confidence: 89%

Section: Mrs Reference Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quantitative Ultrasound for Staging of Hepatic Steatosis in Patients on Home Parenteral Nutrition Validated with Magnetic Resonance Spectroscopy: A Feasibility Study

Weijers

Wanten

Thijssen

et al. 2016

Ultrasound in Medicine & Biology

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“…Since Fatty Liver Diseases are currently the focal point of liver diseases, such studies have significantly increased. According to the employed technology, the image analysis methods for steatosis assessment can be categorized as (i) Histological/Biopsy; (ii) CT [9,10]; (iii) US [11,12]; and (iv) MRI analysis [2,13]. Reasonably, advantages and disadvantages of these methods can be also listed according to the technology used.…”

Section: Related Workmentioning

confidence: 99%

Automated Detection of Liver Histopathological Findings Based on Biopsy Image Processing

et al. 2017

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Hepatic steatosis is the accumulation of fat in the hepatic cells and the liver. Triglycerides and other kinds of molecules are included in the lipids. When there is some defect in the process, hepatic steatosis arise, during which the free fatty acids are taken by the liver and exuded as lipoproteins. Alcohol is the main cause of steatosis when excessive amounts are consumed for a long period of time. In many cases, steatosis can lead to inflammation that is mentioned as steatohepatitis or non-alcoholic steatohepatitis (NASH), which can later lead to fibrosis and finally cirrhosis. For automated detection and quantification of hepatic steatosis, a novel two-stage methodology is developed in this study. Initially, the image is processed in order to become more suitable for the detection of fat regions and steatosis quantification. In the second stage, initial candidate image regions are detected, and then they are either validated or discarded based on a series of criteria. The methodology is based on liver biopsy image analysis, and has been tested using 40 liver biopsy images obtained from patients who suffer from hepatitis C. The obtained results indicate that the proposed methodology can accurately assess liver steatosis.

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Assessment of the frequency dependence of acoustic properties on material, composition, and scatterer size of the medium

et al. 2022

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Transcutaneous vs. Intraoperative Quantitative Ultrasound for Staging Bovine Hepatic Steatosis

Cited by 30 publications

References 21 publications

Quantitative Ultrasound for Staging of Hepatic Steatosis in Patients on Home Parenteral Nutrition Validated with Magnetic Resonance Spectroscopy: A Feasibility Study

Quantitative Ultrasound for Staging of Hepatic Steatosis in Patients on Home Parenteral Nutrition Validated with Magnetic Resonance Spectroscopy: A Feasibility Study

Automated Detection of Liver Histopathological Findings Based on Biopsy Image Processing

Assessment of the frequency dependence of acoustic properties on material, composition, and scatterer size of the medium

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