2024
DOI: 10.1002/adma.202411092
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Transcytosable and Ultrasound‐Activated Liposome Enables Deep Penetration of Biofilm for Surgical Site Infection Management

Guowei Wang,
Chengyue Zhang,
Zixuan Huang
et al.

Abstract: Biofilm‐associated surgical site infection (BSSI) is a common and grievous postoperative complication lacking effective remedies, mainly due to the poor drug accumulation and penetration in the biofilms featured by dense extracellular polymeric substances (EPSs). Here, it is found that the vascular cell adhesion molecule‐1 (VCAM1) is highly overexpressed in the vascular cells of BSSI. It is proposed that the combination of VCAM1‐mediated transcytosis and ultrasonic cavitation can consecutively overcome the bio… Show more

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