Transdermal amperometric biosensors for continuous glucose monitoring in diabetes

Liu, Yiqun; Yang, Li; Cui, Yue

doi:10.1016/j.talanta.2022.124033

Cited by 13 publications

(11 citation statements)

References 240 publications

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“…Thus, they are often accompanied by the risk of pain, bleeding, and infection, resulting in decreased comfort and inadequate treatment compliance for long-time wearing (Figure 8g). 107 Second, current implantable electrodes can only detect one single indicator due to the constraints of the sophisticated electrode surface and microfabrication process, limiting multiple biochemical detection and drug delivery. Meanwhile, H 2 O 2 generated from glucose decomposition is susceptible to interference by reactive oxygen species in the tissue microenvironment.…”

Section: ■ Invasive Cgm Technology Based On Implantable Electrodes Fo...mentioning

confidence: 99%

“…To implant the detection probe smoothly under the skin, it is difficult to avoid skin puncture by metal needles during the installation process. Reproduced with permission from ref . Copyright 2023 Elsevier.…”

Section: Invasive Cgm Technology Based On Implantable Electrodes For ...mentioning

confidence: 99%

“…Commonly used implantable electrodes are typically 0.5–1 cm in length and tend to contact nerves and blood vessels in subcutaneous tissues during insertion (Figure f). Thus, they are often accompanied by the risk of pain, bleeding, and infection, resulting in decreased comfort and inadequate treatment compliance for long-time wearing (Figure g) . Second, current implantable electrodes can only detect one single indicator due to the constraints of the sophisticated electrode surface and microfabrication process, limiting multiple biochemical detection and drug delivery.…”

Section: Invasive Cgm Technology Based On Implantable Electrodes For ...mentioning

confidence: 99%

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Technological Advances of Wearable Device for Continuous Monitoring of In Vivo Glucose

Huang,

Yao,

Huang

et al. 2024

ACS Sens.

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Managing diabetes is a chronic challenge today, requiring monitoring and timely insulin injections to maintain stable blood glucose levels. Traditional clinical testing relies on fingertip or venous blood collection, which has facilitated the emergence of continuous glucose monitoring (CGM) technology to address data limitations. Continuous glucose monitoring technology is recognized for tracking long-term blood glucose fluctuations, and its development, particularly in wearable devices, has given rise to compact and portable continuous glucose monitoring devices, which facilitates the measurement of blood glucose and adjustment of medication. This review introduces the development of wearable CGM-based technologies, including noninvasive methods using body fluids and invasive methods using implantable electrodes. The advantages and disadvantages of these approaches are discussed as well as the use of microneedle arrays in minimally invasive CGM. Microneedle arrays allow for painless transdermal puncture and are expected to facilitate the development of wearable CGM devices. Finally, we discuss the challenges and opportunities and look forward to the biomedical applications and future directions of wearable CGM-based technologies in biological research.

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Section: ■ Invasive Cgm Technology Based On Implantable Electrodes Fo...mentioning

confidence: 99%

Section: Invasive Cgm Technology Based On Implantable Electrodes For ...mentioning

confidence: 99%

Section: Invasive Cgm Technology Based On Implantable Electrodes For ...mentioning

confidence: 99%

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Technological Advances of Wearable Device for Continuous Monitoring of In Vivo Glucose

Huang,

Yao,

Huang

et al. 2024

ACS Sens.

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“…In clinical testing, glucose sensors are integrated into the continuous glucose monitoring system (CGMS) for real-time glucose data collection from patients. CGM can overcome the inconvenience caused by fingertip blood collection and the disadvantage of not being able to track blood glucose fluctuations [ 14 , 15 ] and is used to help patients with diabetes and their healthcare providers more effectively manage care [ 16 ]; so, the development of CGM devices has received increasing attention [ 17 , 18 ]. They provide important information for diabetic control, including the instantaneous real-time display of the glucose level and glucose change rate, alerts and alarms for actual or impending hypo- and hyperglycemia, “24/7” coverage, and the ability to characterize glycemic variability, so the preparation of flexible glucose sensors with excellent performance is the focus of the development of next-generation CGM devices.…”

Section: Introductionmentioning

confidence: 99%

A High-Linearity Glucose Sensor Based on Silver-Doped Con A Hydrogel and Laser Direct Writing

Yang

Zhang

et al. 2023

Polymers

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A continuous glucose monitoring (CGM) system is an ideal monitoring system for the blood glucose control of diabetic patients. The development of flexible glucose sensors with good glucose-responsive ability and high linearity within a large detection range is still challenging in the field of continuous glucose detection. A silver-doped Concanavalin A (Con A)-based hydrogel sensor is proposed to address the above issues. The proposed flexible enzyme-free glucose sensor was prepared by combining Con-A-based glucose-responsive hydrogels with green-synthetic silver particles on laser direct-writing graphene electrodes. The experimental results showed that in a glucose concentration range of 0–30 mM, the proposed sensor is capable of measuring the glucose level in a repeatable and reversible manner, showing a sensitivity of 150.12 Ω/mM with high linearity of R2 = 0.97. Due to its high performance and simple manufacturing process, the proposed glucose sensor is excellent among existing enzyme-free glucose sensors. It has good potential in the development of CGM devices.

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“…90 Microfabricated chips are used in the commercial Abbot Freestyle Libre system, and consist of gold working electrodes with a 40-120 nm thickness. 91 Miniaturization of the electrode geometry, enabled by microfabrication, 92 can be used to enhance mass transport, decrease ohmic drop, and increase the signal-to-noise ratio of electrochemical systems. 93 The small size of microfabricated electrodes also makes them suitable for integration with microfluidic devices.…”

mentioning

confidence: 99%

Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

Akhlaghi,

Kaur,

Adhikari

et al. 2024

ECS Sens. Plus

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There is a plethora of electrochemical biosensors developed for ultrasensitive detection of clinically-relevant biomarkers. However, many of these systems lose their performance in heterogeneous clinical samples and are too complex to be operated by end users at the point-of-care (POC), prohibiting their commercial success. Integration of biosensors with sample processing technology addresses both of these challenges; however, it adds to the manufacturing complexity and the overall cost of these systems. Herein, we review the different components of a biosensor and avenues for creating fully-integrated systems. In the context of integration, we focus on discussing the trade-offs between sensing performance, cost, and scalable manufacturing to guide the readers toward designing new electrochemical biosensors with commercialization potential.

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Transdermal amperometric biosensors for continuous glucose monitoring in diabetes

Cited by 13 publications

References 240 publications

Technological Advances of Wearable Device for Continuous Monitoring of In Vivo Glucose

Technological Advances of Wearable Device for Continuous Monitoring of In Vivo Glucose

A High-Linearity Glucose Sensor Based on Silver-Doped Con A Hydrogel and Laser Direct Writing

Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

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