Transdermal controlled delivery of verapamil: determination of in vitro/in vivo relationship

Shah, Hemanshu S.; Tojo, Kakuji; Chien, Yie W.

doi:10.1016/0168-3659(92)90198-z

Cited by 3 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(6) The body pharmacokinetics is defined to follow two-compartment model (Shah et al, 1992c;Anderson et al, 1982). The two-compartment model for verapamil has been chosen in consistency with previous studies which indicate this to be a better model as compared to the one-compartment model (Bertera et al, 2008;Syvanen et al, 2008).…”

Section: Model Assumptionsmentioning

confidence: 89%

“…This assumption has also been previously explained in detail in Al-Qalaf et al (2009c) and Davidson et al (2008). (8) The back diffusion of verapamil in skin is ignored (Al-Qallaf et al, 2007;Tojo, 2005;Shah et al, 1992c). This has been done since the diffusion coefficient of verapamil is small in the stratum corneum (Shah et al, 1992c).…”

Section: Model Assumptionsmentioning

confidence: 90%

“…(8) The back diffusion of verapamil in skin is ignored (Al-Qallaf et al, 2007;Tojo, 2005;Shah et al, 1992c). This has been done since the diffusion coefficient of verapamil is small in the stratum corneum (Shah et al, 1992c). Therefore, it seems to be acceptable to ignore the back diffusion (Tojo, 2005).…”

Section: Model Assumptionsmentioning

confidence: 99%

“…There are two main transdermal drug delivery systems in the figure: a transdermal patch containing verapamil at a homogeneous concentration (Shah et al, 1992c) and a microneedle array coated with verapamil solution (Davidson et al, 2008). Application of the transdermal patch is divided into two hypothetical cases that represent application on the top of either the stratum corneum or viable epidermis.…”

Section: Modeling Strategymentioning

confidence: 99%

“…Verapamil is assumed to be delivered at a constant rate, i.e., a constant skin surface concentration is maintained (Shah et al, 1992c). At the interface between stratum corneum and viable skin, the verapamil concentration is:…”

Section: Governing Equations Characterizing the Skin Concentrationmentioning

confidence: 99%

See 4 more Smart Citations

Transdermal Drug Delivery by Microneedles: Does Skin Metabolism Matter?

Al-Qallaf¹,

Mori²,

Olatunji³

et al. 2009

International Journal of Chemical Reactor Engineering

View full text Add to dashboard Cite

Microneedle arrays have been shown to increase skin permeability for the transdermal delivery of drugs with high molecular weights. Various theoretical studies have been proposed to predict the drug transport behaviour after drug injection using microneedles. However it is important for the optimal design of microneedle systems to consider the effects of biological factors such as skin metabolism and variations in pharmacokinetic parameters as well as to improve the enhancement of skin permeability. A mathematical model for microneedle systems is introduced and applied to simulate the verapamil transport with metabolism in the skin. A comparative analysis for a transdermal delivery of verapamil from microneedles is presented in this paper. The results indicate that the skin metabolism does not markedly affect the skin permeation after verapamil injection using microneedles.

show abstract

Section: Model Assumptionsmentioning

confidence: 89%

Section: Model Assumptionsmentioning

confidence: 90%

Section: Model Assumptionsmentioning

confidence: 99%

Section: Modeling Strategymentioning

confidence: 99%

Section: Governing Equations Characterizing the Skin Concentrationmentioning

confidence: 99%

See 3 more Smart Citations

Transdermal Drug Delivery by Microneedles: Does Skin Metabolism Matter?

Al-Qallaf¹,

Mori²,

Olatunji³

et al. 2009

International Journal of Chemical Reactor Engineering

View full text Add to dashboard Cite

show abstract

Metabolism and retention of verapamil dictate microneedle-based drug delivery: analytical and numerical study

Bhuimali,

Sarifuddin,

Mandal

2024

Proc. R. Soc. A.

View full text Add to dashboard Cite

This study systematically investigates, both analytically and numerically, transdermal drug delivery using a microneedle (MN) array. The drug released from the MN tip disperses through the viable skin before being absorbed in the blood compartment. Reversible uptake kinetics between the blood and tissue compartments, together with reversible specific binding of the drug with its receptors in the tissue, have been taken into account. The governing equations are solved analytically and numerically in an explicit manner. Simulations predict that the metabolism in the viable skin, irreversible uptake and specific binding have a stabilizing effect on the free and bound verapamil concentrations. In addition, a longer MN and a larger skin–blood interface area contribute to higher concentrations of all drug forms in the blood and tissue compartments. The results suggest that the lack of binding in the tissue compartment might overestimate the transdermal delivery of verapamil. A thorough sensitivity analysis has been performed to account for uncertainties in some of the parameters involved. The analysis of verapamil retention in the tissue and its relationship to the length of the MN, the time of application, the area of the skin–blood interface, the rate of metabolism and the reversible uptake kinetics between compartments constitute the novel aspect of this analytical and numerical work. Our reduced model is in excellent agreement with the results available in the literature.

show abstract

TRANSDERMAL FORMULATIONS CONTAINING HUMAN SEXUAL STEROIDS: DEVELOPMENT AND VALIDATION OF METHODS ANDIN VITRODRUG RELEASE

et al. 2014

View full text Add to dashboard Cite

In vitro release of bioidentical hormones in four different liposomal transdermal emulsions (containing testosterone, progesterone, estradiol, or estradiol and estriol) was assessed. For this purpose, novel high-performance liquid chromatography methods were developed and validated in an eco-friendly manner and used to determine the in vitro release of such products. The methods were suitable for our intended goal, and the emulsions employed were found to be effective as transporting candidates for the efficient release of hormones in the transdermal delivery of human sexual steroids.

show abstract

Transdermal controlled delivery of verapamil: determination of in vitro/in vivo relationship

Cited by 3 publications

References 15 publications

Transdermal Drug Delivery by Microneedles: Does Skin Metabolism Matter?

Transdermal Drug Delivery by Microneedles: Does Skin Metabolism Matter?

Metabolism and retention of verapamil dictate microneedle-based drug delivery: analytical and numerical study

TRANSDERMAL FORMULATIONS CONTAINING HUMAN SEXUAL STEROIDS: DEVELOPMENT AND VALIDATION OF METHODS ANDIN VITRODRUG RELEASE

Contact Info

Product

Resources

About