Transdermal Delivery of Antihypertensive Agents: A tabular update.

Jain, Ashish; Mishra, Anurag; Nayak, Sunita; Soni, Vandana

doi:10.5138/ijdd.2010.0975.0215.03049

Cited by 10 publications

(7 citation statements)

References 40 publications

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“…Additionally, chitosan nanoparticles can be functionalized with various molecules, such as permeation enhancers and targeting ligands, to further improve their efficacy in TDD. Several studies have investigated the use of chitosan nanoparticles for transdermal delivery of various drugs, including antihypertensives [ 50 ], anti-inflammatory agents, and anticancer drugs [ 51 ]. Also, in vitro and in vivo studies have demonstrated the potential of chitosan nanoparticles for transdermal delivery of these drugs [ 52 ], showing improved permeation and bioavailability compared to conventional formulations.…”

Section: Resultsmentioning

confidence: 99%

Advances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis

Cammarano,

Dello Iacono,

Meglio

et al. 2023

Pharmaceutics

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Transdermal drug delivery systems have become an intriguing research topic in healthcare technology and one of the most frequently developed pharmaceutical products in the global market. In recent years, researchers and pharmaceutical companies have made significant progress in developing new solutions in the field. This study sheds light on current trends, collaboration patterns, research hotspots, and emerging frontiers of transdermal drug delivery. Herein, a bibliometric and patent analysis of data recovered from Scopus and The Lens databases, respectively, is reported over the last 20 years. From 2000 to 2022, the annual global publications increased from 131 in 2000 to 659 in 2022. Researchers in the United States, China, and India produced the highest number of publications. Likewise, most patent applications have been filed in the USA, China, and Europe. The recovered patents are 7275, grouped into 2997 patent families, of which 314 were granted. This study could support the work of decision-makers, scientific managers, or scientists to create new business opportunities or save money, time, and intellectual capital, thereby defining when a research or technology project should be a priority or not.

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Section: Resultsmentioning

confidence: 99%

Advances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis

Cammarano,

Dello Iacono,

Meglio

et al. 2023

Pharmaceutics

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show abstract

“…After 10 minutes of immersion, the membrane can be removed, air dry in a circulation oven at 50°C for 12 hrs. [51][52] Circular Teflon mould method: Solutions with different ratios of polymers are utilised in an organic solvent. Half as much of the same organic solvent is used to dissolve the calculated amount of medication.…”

Section: Asymmetric Tpx Membrane Methodmentioning

confidence: 99%

A Review on Advanced Transdermal Paches and Their Evaluation

A. M.,

S. D.,

N. N.

et al. 2023

ijnrph

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Transdermal patches are an innovative method of delivering medication directly into the bloodstream through the skin. In 1979, the United States authorized the use of the initial transdermal technique for systemic delivery—a three-day patch that administers scopolamine to alleviate motion sickness. The initial breakthrough in transdermal delivery came with the introduction of nicotine patches. This paved the way for greater awareness and acceptance of transdermal technology in the medical field and among the general population, gaining significant popularity a decade later. Currently, there are 19 different transdermal delivery methods available for medications such as oestradiol, fentanyl, lidocaine, and testosterone. Additionally, there are combination patches available that contain multiple medications for hormone replacement and contraception. There are also iontophoretic and ultrasonic analgesia delivery systems that can be used. They provide several benefits compared to conventional oral medication, such as improved patient adherence, regulated drug delivery, and reduced side effects. The medication is typically contained within a matrix or reservoir within the patch, and is gradually released over a period of time. The patch may require periodic changes, typically every few days or weeks, depending on the specific medication and dosage. Transdermal patches have a broad range of applications, encompassing painkillers, hormones, and nicotine replacement therapy. They are widely regarded as safe and effective, with minimal side effects. It is important to carefully adhere to the instructions for use to avoid potential skin irritation or other issues.

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“…[35][36][37] Also, it was observed that Fe 3+ ions gave a stable complex with chlorphenamine, having a similar structure to histamine, at pH 6.0 (log b: 3.6 at ratio of 1 : 1). 38 Thus, the effect of Fe(III) ion concentration on the recovery of histamine was investigated in the range of 1 to 60 mmol L À1 . The results are shown in Fig.…”

Section: Optimization Of the Variables Affecting Complex Formation An...mentioning

confidence: 99%

A new atomic absorption-based method development for indirect determination of histamine in fish samples, dairy products, and alcoholic beverages by flame AAS

2016

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A new and sensitive analytical method for the indirect determination of histamine in fish samples, dairy products, and alcoholic beverages by flame atomic absorption spectrometry (FAAS) was developed. The method was based on the complex formation of histamine with Fe(III) and 2 0 ,4 0 ,5 0 ,7 0tetrabromofluorescein (eosin) at pH 4.5, and then extraction into the micellar phase of polyethylene glycol dodecyl ether (Brij 35). In this study, an ultrasonic assisted cloud point extraction (UA-CPE) procedure was used for the separation/pre-concentration of histamine from the related sample matrices. The optimal conditions were established and a good pre-concentration was achieved using 25 mmol L À1 Fe(III), 5 mmol L À1 eosin, 10 mmol L À1 Brij 35, 0.7% (w/v) Na 2 SO 4 , pH 4.5 citrate buffer, equilibrium temperature of 45 C, incubation time of 20 min and ultrasonication at 40 kHz and 300 W.At optimal conditions, a detection limit of 0.25 mg L À1 with a sensitivity improvement of 143-fold in the linear working range of 0.8-170 mg L À1 was obtained. The proposed method was evaluated for the analysis of some food samples and received a good recovery with the standard addition assay. In addition, the validity of the method was tested by intra-day and inter-day precision studies and recovery experiments, obtaining satisfactory results. To the best of our knowledge, this method was also the first study for indirect determination of histamine in the selected samples using UA-CPE coupled to FAAS.

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Transdermal Delivery of Antihypertensive Agents: A tabular update.

Cited by 10 publications

References 40 publications

Advances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis

Advances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis

A Review on Advanced Transdermal Paches and Their Evaluation

A new atomic absorption-based method development for indirect determination of histamine in fish samples, dairy products, and alcoholic beverages by flame AAS

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