Transdermal delivery of bovine milk vesicles in patients with multiple sclerosis: A novel strategy to induce MOG-specific tolerance

Mokarizadeh, Aram; Hassanzadeh, Kambiz; Abdi, Mohammad; Soraya, Hamid; Faryabi, Mohammad Reza; Mohammadi, Ebrahim; Ahmadi, Abbas

doi:10.1016/j.mehy.2015.04.019

Cited by 13 publications

(3 citation statements)

References 33 publications

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“…The surface of milkderived EVs contains casein protein, which exhibits a 50% sequence homology with that of MOG. Studies have shown that milk-derived EVs can treat MS in mouse models (Mokarizadeh et al, 2015); in addition, the application of milk-derived EVs in the treatment of MS in humans requires further study.…”

Section: Potential Application Of Milk-derived Evsmentioning

confidence: 99%

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant

Jiang

You

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Extracellular vesicles (EVs) are released by all cells under pathological and physiological conditions. EVs harbor various biomolecules, including protein, lipid, non-coding RNA, messenger RNA, and DNA. In 2007, mRNA and microRNA (miRNA) carried by EVs were found to have regulatory functions in recipient cells. The biological function of EVs has since then increasingly drawn interest. Breast milk, as the most important nutritional source for infants, contains EVs in large quantities. An increasing number of studies have provided the basis for the hypothesis associated with information transmission between mothers and infants via breast milk-derived EVs. Most studies on milk-derived EVs currently focus on miRNAs. Milk-derived EVs contain diverse miRNAs, which remain stable both in vivo and in vitro; as such, they can be absorbed across different species. Further studies have confirmed that miRNAs derived from milk-derived EVs can resist the acidic environment and enzymatic hydrolysis of the digestive tract; moreover, they can be absorbed by intestinal cells in infants to perform physiological functions. miRNAs derived from milk EVs have been reported in the maturation of immune cells, regulation of immune response, formation of neuronal synapses, and development of metabolic diseases such as obesity and diabetes. This article reviews current status and advances in milk-derived EVs, including their history, biogenesis, molecular contents, and biological functions. The effects of milk-derived EVs on growth and development in both infants and adults were emphasized. Finally, the potential application and future challenges of milk-derived EVs were discussed, providing comprehensive understanding and new insight into milk-derived EVs.

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Section: Potential Application Of Milk-derived Evsmentioning

confidence: 99%

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant

Jiang

You

Zhang

et al. 2021

Front. Cell Dev. Biol.

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“…It has been identified in milk-derived exosomes and the milk fat globule membrane (MFGM), which are vesicular structures found in milk. 183 …”

Section: Treatment and Prevention Of Diseases Through Food-derived Ex...mentioning

confidence: 99%

The emerging role of medical foods and therapeutic potential of medical food-derived exosomes

Hur,

Lee,

Shin

et al. 2024

Nanoscale Adv.

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“…In response to chemotherapeutic side effects, msEVs protect macrophages from cisplatin-induced cytotoxicity [ 136 ]. A protein known as butyryl protein (BTN), which shares an epitope with the myelin oligodendrocyte glycoprotein (MOG), was identified in milk, and transdermal administration of msEVs to patients with multiple sclerosis induced the development of MOG-specific tolerance for use in MOG-specific immunotherapy [ 137 ]. MsEVs can be an effective medicinal ingredient to improve skin lightening.…”

Section: Composition and Functions Of Msevsmentioning

confidence: 99%

Multifunctional Milk-Derived Small Extracellular Vesicles and Their Biomedical Applications

et al. 2023

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In recent years, small extracellular vesicles (sEVs) have been regarded as the next generation of novel delivery systems after lipid nanoparticles because of their advantages and huge prospects in drug delivery. Studies have shown that sEVs are abundant in milk and therefore can be a large and economical source of sEVs. Natural milk-derived small extracellular vesicles (msEVs) have important functions such as immune regulation, anti-bacterial infection, anti-oxidative, etc., and play a beneficial role in human health at multiple levels, including intestinal health, bone/muscle metabolism, and microbiota regulation. In addition, because they can pass the gastrointestinal barrier and have low immunogenicity, good biocompatibility, and stability, msEVs are considered a crucial oral drug delivery vehicle. Moreover, msEVs can be further engineered for targeted delivery to prolong the circulation time or enhance local drug concentrations. However, msEVs separation and purification, complex contents, and quality control hinder their application in drug delivery. This paper provides a comprehensive review of the biogenesis and characteristics, isolation and purification, composition, loading methods, and function of msEVs, based on which their applications in biomedical fields are further explored.

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Transdermal delivery of bovine milk vesicles in patients with multiple sclerosis: A novel strategy to induce MOG-specific tolerance

Cited by 13 publications

References 33 publications

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant

The emerging role of medical foods and therapeutic potential of medical food-derived exosomes

Multifunctional Milk-Derived Small Extracellular Vesicles and Their Biomedical Applications

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